SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 9 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.18A 1pxxB-5mlzA:
2.0		 1pxxB-5mlzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 10 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.18A 1pxxD-5mlzA:
undetectable		 1pxxD-5mlzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 237
ASN A 281
PHE A 301
SER A 273
 CL  A 403 ( 4.8A)
None
CL  A 403 (-4.6A)
LDA  A 408 (-3.4A)
 1.48A 1rqpB-5mlzA:
2.2		 1rqpB-5mlzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 PHE A 301
ASN A 345
PHE A 237
SER A 337
 CL  A 403 (-4.6A)
None
CL  A 403 ( 4.8A)
None
 1.22A 1rqpB-5mlzA:
2.2		 1rqpB-5mlzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		4 / 8 PHE A 301
ASN A 345
PHE A 237
SER A 337
 CL  A 403 (-4.6A)
None
CL  A 403 ( 4.8A)
None
 1.20A 1rqpC-5mlzA:
2.2		 1rqpC-5mlzA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 ALA A  72
ILE A  61
ASP A  39
LEU A  16
ILE A   7
 GDP  A 401 (-3.4A)
None
GDP  A 401 (-3.1A)
None
None
 1.06A 3clbC-5mlzA:
undetectable		 3clbC-5mlzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 10 ALA A  49
ILE A  34
ILE A   6
ILE A  61
THR A  45
 None
 1.23A 3clbD-5mlzA:
undetectable		 3clbD-5mlzA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.19A 3pghA-5mlzA:
1.8		 3pghA-5mlzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		4 / 5 LEU A 242
GLY A 244
PHE A 338
ASN A 281
 None
LDA  A 408 (-4.6A)
None
None
 1.20A 3uq6B-5mlzA:
undetectable		 3uq6B-5mlzA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.14A 4coxA-5mlzA:
undetectable		 4coxA-5mlzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.15A 4coxB-5mlzA:
2.5		 4coxB-5mlzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.14A 4coxC-5mlzA:
1.3		 4coxC-5mlzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.15A 4coxD-5mlzA:
undetectable		 4coxD-5mlzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 204
GLU A  18
ASN A  15
 None
 0.90A 4imaD-5mlzA:
4.7		 4imaD-5mlzA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		3 / 3 ARG A 204
GLU A  18
ASN A  15
 None
 0.90A 4ip7D-5mlzA:
4.6		 4ip7D-5mlzA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		6 / 12 ILE A   6
ALA A  72
PHE A  77
ILE A 183
LEU A 162
VAL A  87
 None
GDP  A 401 (-3.4A)
None
None
None
None
 1.37A 4kfjB-5mlzA:
undetectable		 4kfjB-5mlzA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 179
ILE A 183
ALA A 161
VAL A 167
VAL A 166
 None
 1.06A 4nkxA-5mlzA:
undetectable		 4nkxA-5mlzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		4 / 7 VAL A 156
GLY A 137
ALA A 138
SER A 135
 None
 0.86A 5f1aB-5mlzA:
undetectable		 5f1aB-5mlzA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mlz DOLICHOL
MONOPHOSPHATE
MANNOSE SYNTHASE
(Pyrococcus
furiosus) 		5 / 12 VAL A 156
VAL A 141
GLY A 137
ALA A 138
SER A 135
 None
 1.17A 5ikrA-5mlzA:
undetectable		 5ikrA-5mlzA:
22.07