SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mm2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5mm2 CAPSID PROTEIN VP4A
(Nora
virus) 		3 / 3 TRP C 217
ALA C  87
VAL C  17
 None
 0.98A 1bdwA-5mm2C:
undetectable
1bdwB-5mm2C:
undetectable		 1bdwA-5mm2C:
undetectable
1bdwB-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 5mm2 CAPSID PROTEIN VP4B
(Nora
virus) 		5 / 11 ILE B 200
ASN B 195
SER B  66
PHE B 147
PHE B 194
 None
 1.46A 1ho5A-5mm2B:
undetectable		 1ho5A-5mm2B:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		5 / 9 GLY A 118
GLY A 161
ILE A 212
VAL A  54
ILE A 259
 None
 0.99A 1hxwA-5mm2A:
undetectable		 1hxwA-5mm2A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5mm2 CAPSID PROTEIN VP4B
(Nora
virus) 		4 / 6 HIS B  20
ASP B  19
ASP B 213
PRO B  24
 None
 1.34A 1ilqA-5mm2B:
undetectable
1ilqC-5mm2B:
undetectable		 1ilqA-5mm2B:
15.07
1ilqC-5mm2B:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		5 / 12 GLY A 161
VAL A 163
ALA A 153
HIS A 122
LEU A 121
 None
 1.29A 1kiaD-5mm2A:
undetectable		 1kiaD-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		5 / 12 GLY A 118
GLY A 161
ILE A 212
VAL A  54
ILE A 259
 None
 0.86A 2o4sA-5mm2A:
undetectable		 2o4sA-5mm2A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 5mm2 CAPSID PROTEIN VP4A
(Nora
virus) 		4 / 5 LEU C  24
ASP C  31
ALA C  25
ILE C 168
 None
 1.08A 2qhfA-5mm2C:
undetectable		 2qhfA-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mm2 CAPSID PROTEIN VP4A
(Nora
virus) 		5 / 12 HIS C  51
THR C 109
GLN C 112
LEU C 116
ILE C  81
 None
 1.44A 2xrlA-5mm2C:
undetectable		 2xrlA-5mm2C:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_B_SAMB238_1
(N,N-DIMETHYLTRANSFER
ASE)		 5mm2 CAPSID PROTEIN VP4B
(Nora
virus) 		3 / 3 TYR B 241
GLU B 232
ASP B 227
 None
 0.89A 3bxoB-5mm2B:
undetectable		 3bxoB-5mm2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5mm2 CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4A
(Nora
virus;
Nora
virus) 		4 / 6 GLY C  37
GLU B   8
GLY B   9
ASN B 120
 None
 0.98A 3e9rA-5mm2C:
undetectable		 3e9rA-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5mm2 CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4A
(Nora
virus;
Nora
virus) 		4 / 6 GLY C  37
GLU B   8
GLY B   9
ASN B 120
 None
 0.99A 3e9rC-5mm2C:
undetectable		 3e9rC-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 5mm2 CAPSID PROTEIN VP4C
CAPSID PROTEIN VP4B
(Nora
virus;
Nora
virus) 		4 / 6 THR B  55
PHE A  88
ARG A  87
PHE A 277
 None
 1.49A 4kf9A-5mm2B:
undetectable		 4kf9A-5mm2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_2
(PROTEASE)		 5mm2 CAPSID PROTEIN VP4A
(Nora
virus) 		5 / 9 ARG C  91
ALA C  95
VAL C 132
VAL C 216
ILE C 214
 None
 1.15A 4ll3B-5mm2C:
undetectable		 4ll3B-5mm2C:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 5mm2 CAPSID PROTEIN VP4B
(Nora
virus) 		4 / 6 MET B  71
ILE B 119
ILE B 121
VAL B 205
 None
 0.94A 4olmA-5mm2B:
undetectable		 4olmA-5mm2B:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4C
(Nora
virus) 		4 / 5 ARG A 279
THR C 153
ASP A 278
TYR B  58
 None
 1.44A 4oltA-5mm2A:
undetectable		 4oltA-5mm2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4C
(Nora
virus) 		4 / 5 ARG A 279
THR C 153
ASP A 278
TYR B  58
 None
 1.40A 4oltB-5mm2A:
undetectable		 4oltB-5mm2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		4 / 5 GLN A  86
SER A  82
ASP A  65
ASP A 292
 None
 1.34A 4qtuB-5mm2A:
undetectable		 4qtuB-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4C
(Nora
virus) 		4 / 5 ARG A 279
THR C 153
ASP A 278
TYR B  58
 None
 1.41A 4qwpA-5mm2A:
undetectable		 4qwpA-5mm2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4B
CAPSID PROTEIN VP4C
(Nora
virus) 		4 / 5 ARG A 279
THR C 153
ASP A 278
TYR B  58
 None
 1.37A 4qwpB-5mm2A:
undetectable		 4qwpB-5mm2A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		3 / 3 GLN A 233
HIS A 339
ARG A 337
 None
 1.13A 4qyqA-5mm2A:
undetectable		 4qyqA-5mm2A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		3 / 3 GLN A 233
HIS A 339
ARG A 337
 None
 1.08A 4qyqB-5mm2A:
undetectable		 4qyqB-5mm2A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4C
(Nora
virus) 		4 / 7 PRO A  93
GLU A 273
TRP C 174
ASP C 125
 None
 1.23A 4uacA-5mm2A:
undetectable		 4uacA-5mm2A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		5 / 12 PRO A  46
ALA A 207
VAL A 163
GLY A 183
THR A 198
 None
 1.36A 5igpA-5mm2A:
undetectable		 5igpA-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5mm2 CAPSID PROTEIN VP4A
(Nora
virus) 		3 / 3 VAL C  43
TYR C  61
GLN C  62
 None
 0.73A 5qgrA-5mm2C:
undetectable		 5qgrA-5mm2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 5mm2 CAPSID PROTEIN VP4C
(Nora
virus) 		5 / 12 LEU A 143
THR A 149
GLY A 148
PRO A 126
ILE A 137
 None
 1.16A 5tuiB-5mm2A:
undetectable		 5tuiB-5mm2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 5mm2 CAPSID PROTEIN VP4A
CAPSID PROTEIN VP4B
(Nora
virus) 		4 / 6 TYR C 141
LEU B 131
LYS B  62
LEU B  65
 None
 1.25A 5xooA-5mm2C:
undetectable		 5xooA-5mm2C:
17.05