SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_1
(VP39)		 5mm4 KINESIN-5
(Ustilago
maydis) 		3 / 3 ASP K 176
ARG K 231
ASP K 171
 None
 0.95A 1vptA-5mm4K:
undetectable		 1vptA-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 5mm4 KINESIN-5
(Ustilago
maydis) 		4 / 8 LEU K 229
LEU K 226
LEU K 123
ALA K 134
 None
 0.77A 2vcvP-5mm4K:
undetectable		 2vcvP-5mm4K:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5mm4 KINESIN-5
(Ustilago
maydis) 		3 / 3 ARG K 355
VAL K 351
THR K 361
 None
 0.81A 3k4vD-5mm4K:
undetectable		 3k4vD-5mm4K:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5mm4 KINESIN-5
(Ustilago
maydis) 		5 / 11 GLY K  26
PRO K  25
THR K  29
GLY K  32
PRO K  33
 None
 1.38A 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
0.5		 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5mm4 KINESIN-5
(Ustilago
maydis) 		5 / 11 THR K  29
GLY K  32
PRO K  33
GLY K  26
PRO K  25
 None
 1.37A 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
0.5		 3t8nD-5mm4K:
undetectable
3t8nF-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mm4 KINESIN-5
(Ustilago
maydis) 		4 / 8 TYR K 367
THR K 309
TYR K 108
LEU K 331
 None
 1.00A 3wipG-5mm4K:
undetectable
3wipH-5mm4K:
undetectable		 3wipG-5mm4K:
undetectable
3wipH-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mm4 KINESIN-5
(Ustilago
maydis) 		4 / 8 LEU K 331
TYR K 367
THR K 309
TYR K 108
 None
 1.02A 3wipF-5mm4K:
undetectable
3wipJ-5mm4K:
undetectable		 3wipF-5mm4K:
undetectable
3wipJ-5mm4K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 5mm4 KINESIN-5
(Ustilago
maydis) 		3 / 3 ARG K 289
GLU K 360
ASN K 286
 None
 0.78A 4imaD-5mm4K:
undetectable		 4imaD-5mm4K:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 5mm4 KINESIN-5
(Ustilago
maydis) 		3 / 3 ARG K 289
GLU K 360
ASN K 286
 None
 0.75A 4ip7D-5mm4K:
undetectable		 4ip7D-5mm4K:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5mm4 KINESIN-5
(Ustilago
maydis) 		4 / 5 THR K 129
LEU K 123
THR K 118
MET K 119
 None
 1.39A 4mbsB-5mm4K:
undetectable		 4mbsB-5mm4K:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B4Y_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 5mm4 KINESIN-5
(Ustilago
maydis) 		5 / 10 ILE K 347
LEU K 365
VAL K 351
THR K 364
THR K 118
 None
 1.32A 6b4yA-5mm4K:
undetectable		 6b4yA-5mm4K:
undetectable