SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mmd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 8 HIS E 116
CYH E 221
GLY E 220
GLY E 262
TYR E 218
 ZN  E 403 (-3.3A)
ZN  E 401 (-2.3A)
None
None
None
 1.46A 1ekjA-5mmdE:
undetectable
1ekjB-5mmdE:
undetectable		 1ekjA-5mmdE:
20.41
1ekjB-5mmdE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 8 HIS E 116
CYH E 221
GLY E 220
GLY E 262
TYR E 218
 ZN  E 403 (-3.3A)
ZN  E 401 (-2.3A)
None
None
None
 1.45A 1ekjG-5mmdE:
undetectable
1ekjH-5mmdE:
undetectable		 1ekjG-5mmdE:
20.41
1ekjH-5mmdE:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_E_NCAE507_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 7 ILE E 216
PHE E 186
LEU E 187
ASP E  49
 None
 0.95A 1yc2E-5mmdE:
undetectable		 1yc2E-5mmdE:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		3 / 3 LYS E 165
ASP E  84
CYH E 221
 None
None
ZN  E 401 (-2.3A)
 1.13A 2br4F-5mmdE:
undetectable		 2br4F-5mmdE:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 12 HIS E 116
PRO E 192
VAL E 202
LEU E 283
ILE E 223
 ZN  E 403 (-3.3A)
None
None
None
None
 1.20A 2fj1A-5mmdE:
undetectable		 2fj1A-5mmdE:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_J_TACJ5888_1
(ELONGATION FACTOR
EF-TU)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 6 SER E  57
ASP E  91
SER E  69
VAL E  67
 None
 1.25A 2hdnI-5mmdE:
undetectable
2hdnJ-5mmdE:
undetectable
2hdnL-5mmdE:
undetectable		 2hdnI-5mmdE:
10.04
2hdnJ-5mmdE:
22.49
2hdnL-5mmdE:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 6 SER E  69
VAL E  67
SER E  57
ASP E  91
 None
 1.28A 2hdnJ-5mmdE:
undetectable
2hdnK-5mmdE:
undetectable
2hdnL-5mmdE:
undetectable		 2hdnJ-5mmdE:
22.49
2hdnK-5mmdE:
10.04
2hdnL-5mmdE:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 12 GLY E 195
ASP E 199
GLY E 220
ILE E 223
ALA E 246
 None
 0.92A 3n3iA-5mmdE:
undetectable		 3n3iA-5mmdE:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 5 GLY E  78
LYS E  79
GLU E 107
GLY E  77
 None
 0.92A 3onnA-5mmdE:
undetectable		 3onnA-5mmdE:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXY_A_SAMA6734_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 12 VAL E 260
GLY E 264
TYR E  58
ASN E  70
LEU E  72
 None
 1.18A 3qxyA-5mmdE:
undetectable		 3qxyA-5mmdE:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 11 VAL E 260
GLY E 264
TYR E  58
ASN E  70
LEU E  72
 None
 1.18A 3rc0A-5mmdE:
undetectable		 3rc0A-5mmdE:
18.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_A_X8ZA350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		6 / 9 TRP E  87
HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.36A 4c1dA-5mmdE:
34.0		 4c1dA-5mmdE:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		7 / 10 TRP E  87
HIS E 116
HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 403 (-3.3A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.30A 4c1dB-5mmdE:
33.9		 4c1dB-5mmdE:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		8 / 11 VAL E  61
TRP E  64
HIS E 116
HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
None
ZN  E 403 (-3.3A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.45A 4c1fA-5mmdE:
38.1
4c1fB-5mmdE:
37.1		 4c1fA-5mmdE:
49.57
4c1fB-5mmdE:
49.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		7 / 9 HIS E 116
HIS E 118
ASP E 120
HIS E 196
CYH E 221
GLY E 232
HIS E 263
 ZN  E 403 (-3.3A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
CL  E 404 ( 4.8A)
ZN  E 401 (-3.3A)
 0.54A 4c1hA-5mmdE:
33.2		 4c1hA-5mmdE:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		7 / 9 TRP E  87
HIS E 116
ASP E 120
HIS E 196
CYH E 221
GLY E 232
HIS E 263
 None
ZN  E 403 (-3.3A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
CL  E 404 ( 4.8A)
ZN  E 401 (-3.3A)
 0.87A 4c1hA-5mmdE:
33.2		 4c1hA-5mmdE:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 9 TRP E  87
HIS E 196
ASP E 120
CYH E 221
HIS E 263
 None
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 1.27A 4c1hA-5mmdE:
33.2		 4c1hA-5mmdE:
33.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 9 TRP E  87
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.93A 4exsA-5mmdE:
31.9		 4exsA-5mmdE:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EXS_A_X8ZA301_1
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		6 / 9 VAL E  67
HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.26A 4exsA-5mmdE:
31.9		 4exsA-5mmdE:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 8 TRP E  87
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.95A 4exsB-5mmdE:
32.2		 4exsB-5mmdE:
32.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		6 / 8 VAL E  67
HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.32A 4exsB-5mmdE:
32.2		 4exsB-5mmdE:
32.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 6 THR E 197
GLY E 195
ASN E 200
GLY E 232
 ZN  E 403 ( 4.9A)
None
None
CL  E 404 ( 4.8A)
 0.90A 4fjpA-5mmdE:
undetectable		 4fjpA-5mmdE:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 6 GLU E 144
GLN E 167
THR E 197
HIS E 118
 None
None
ZN  E 403 ( 4.9A)
ZN  E 403 (-3.1A)
 1.36A 4pfjB-5mmdE:
undetectable		 4pfjB-5mmdE:
22.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 8 TRP E  87
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.98A 5a5zA-5mmdE:
32.6		 5a5zA-5mmdE:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		6 / 8 VAL E  67
HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.31A 5a5zA-5mmdE:
32.6		 5a5zA-5mmdE:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 7 HIS E 196
CYH E 221
GLY E 232
HIS E 263
 ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
CL  E 404 ( 4.8A)
ZN  E 401 (-3.3A)
 0.31A 5a5zC-5mmdE:
32.4		 5a5zC-5mmdE:
34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 11 HIS E 116
HIS E 118
ASP E 120
HIS E 196
HIS E 263
 ZN  E 403 (-3.3A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-3.3A)
 0.73A 5ayaA-5mmdE:
17.3		 5ayaA-5mmdE:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		3 / 3 THR E 142
ALA E 138
ASN E 143
 None
 0.59A 5ersA-5mmdE:
undetectable		 5ersA-5mmdE:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA302_1
(CHITOSANASE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 7 ASP E 120
ASP E  84
TYR E 218
GLY E 262
 ZN  E 401 (-2.5A)
None
None
None
 1.00A 5hwaA-5mmdE:
undetectable		 5hwaA-5mmdE:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_B_GBMB801_1
(PROLINE--TRNA LIGASE)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 9 LEU E 146
GLU E 119
THR E 122
ILE E 125
GLY E 124
 None
 1.18A 5ifuB-5mmdE:
undetectable		 5ifuB-5mmdE:
17.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 8 HIS E 118
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 ZN  E 403 (-3.1A)
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.26A 5zj8A-5mmdE:
16.7		 5zj8A-5mmdE:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		5 / 8 TRP E  87
ASP E 120
HIS E 196
CYH E 221
HIS E 263
 None
ZN  E 401 (-2.5A)
ZN  E 403 (-3.1A)
ZN  E 401 (-2.3A)
ZN  E 401 (-3.3A)
 0.92A 5zj8A-5mmdE:
16.7		 5zj8A-5mmdE:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5mmd METALLO-BETA-LACTAMA
SE 1
(Acinetobacter
baumannii) 		4 / 5 ASN E  70
GLY E 232
HIS E 263
ASP E 120
 None
CL  E 404 ( 4.8A)
ZN  E 401 (-3.3A)
ZN  E 401 (-2.5A)
 1.03A 6gh9A-5mmdE:
undetectable		 6gh9A-5mmdE:
17.11