SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 231
GLY A 263
ILE A 264
THR A 257
ILE A 122
 None
HEM  A1001 ( 3.9A)
None
PLP  A1002 (-2.9A)
None
 0.87A 1c6yB-5mmsA:
undetectable		 1c6yB-5mmsA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 TRP A 390
ARG A 182
THR A 383
 None
 0.86A 1df7A-5mmsA:
2.0		 1df7A-5mmsA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_A_BEZA1501_0
(ANTHRANILATE
SYNTHASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ILE A 122
GLY A 259
THR A 260
HIS A 232
GLY A 256
 None
PLP  A1002 ( 4.0A)
PLP  A1002 (-3.5A)
None
PLP  A1002 (-3.6A)
 1.06A 1i7qA-5mmsA:
undetectable		 1i7qA-5mmsA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Q_C_BEZC1502_0
(ANTHRANILATE
SYNTHASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 10 ILE A 122
GLY A 259
THR A 260
HIS A 232
GLY A 256
 None
PLP  A1002 ( 4.0A)
PLP  A1002 (-3.5A)
None
PLP  A1002 (-3.6A)
 1.07A 1i7qC-5mmsA:
undetectable		 1i7qC-5mmsA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 4 LEU A 374
VAL A 372
CYH A 370
ALA A 361
 None
 1.17A 1mz9E-5mmsA:
undetectable		 1mz9E-5mmsA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 5 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1002 (-3.6A)
PLP  A1002 (-4.7A)
None
PLP  A1002 (-3.7A)
 0.90A 1rs7A-5mmsA:
undetectable		 1rs7A-5mmsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1002 (-3.6A)
PLP  A1002 (-4.7A)
None
PLP  A1002 (-3.7A)
 0.98A 1rs7B-5mmsA:
undetectable		 1rs7B-5mmsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 153
LEU A 156
ASP A 179
VAL A 178
SER A 349
 None
None
None
None
PLP  A1002 (-2.8A)
 1.14A 1zq9A-5mmsA:
undetectable		 1zq9A-5mmsA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 LEU A  81
GLY A 153
SER A 117
CYH A 165
ALA A 155
 None
 1.17A 2br4D-5mmsA:
2.8		 2br4D-5mmsA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 LEU A 106
MET A  89
MET A 337
 None
 1.04A 2vavF-5mmsA:
undetectable		 2vavF-5mmsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 10 ALA A 361
LEU A 101
VAL A 372
ILE A  95
LEU A 338
 None
 1.23A 3fl9F-5mmsA:
2.9		 3fl9F-5mmsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 ASN A 294
ASP A 281
ARG A  45
 None
 0.95A 3k13C-5mmsA:
undetectable		 3k13C-5mmsA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 VAL A  90
GLY A 347
TYR A 381
ASN A 380
ILE A 339
 None
 1.41A 3owxA-5mmsA:
undetectable
3owxB-5mmsA:
undetectable		 3owxA-5mmsA:
21.32
3owxB-5mmsA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 GLY A 148
GLY A 151
GLN A 222
SER A 174
ASN A 380
 None
 1.00A 3t7sB-5mmsA:
2.7		 3t7sB-5mmsA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLN A 222
TYR A 223
PHE A 310
PRO A  46
 None
 1.39A 3tgvB-5mmsA:
undetectable		 3tgvB-5mmsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLN A 222
TYR A 223
PHE A 310
PRO A  46
 None
 1.34A 3tgvD-5mmsA:
undetectable		 3tgvD-5mmsA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKG_C_ROCC901_1
(PROTEASE)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 12 ALA A 231
GLY A 263
ILE A 264
THR A 257
ILE A 122
 None
HEM  A1001 ( 3.9A)
None
PLP  A1002 (-2.9A)
None
 0.83A 3tkgC-5mmsA:
undetectable		 3tkgC-5mmsA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		3 / 3 ASP A 281
GLU A 283
GLY A 284
 None
 0.70A 3w9tA-5mmsA:
undetectable		 3w9tA-5mmsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		5 / 11 ALA A 155
ILE A 122
VAL A 180
LEU A 181
GLY A 148
 None
 1.05A 3zosA-5mmsA:
undetectable
3zosB-5mmsA:
undetectable		 3zosA-5mmsA:
21.99
3zosB-5mmsA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 6 GLY A 256
ILE A 306
VAL A 118
SER A 254
 PLP  A1002 (-3.6A)
PLP  A1002 (-4.7A)
None
PLP  A1002 (-3.7A)
 0.93A 4kcnA-5mmsA:
undetectable		 4kcnA-5mmsA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 5mms CYSTATHIONINE
BETA-SYNTHASE
(Homo
sapiens) 		4 / 5 LEU A 154
GLY A 153
ILE A 122
GLN A 222
 None
 1.21A 4ma8C-5mmsA:
undetectable		 4ma8C-5mmsA:
15.20