SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4001_1
(SERUM ALBUMIN)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 9 LEU A 261
ILE A 311
LEU A 127
GLY A 130
ALA A 224
 None
 1.25A 1e7aA-5mn5A:
undetectable		 1e7aA-5mn5A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 9 ALA A 224
SER A 247
ILE A 228
ILE A 164
THR A 160
 None
 1.43A 1j3jB-5mn5A:
2.1		 1j3jB-5mn5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 GLY A  23
THR A 102
VAL A  16
ILE A  41
 None
 0.75A 2a1mB-5mn5A:
undetectable		 2a1mB-5mn5A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_1
(PROTEASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ALA A  92
ASP A  91
GLY A  95
VAL A  16
ILE A  41
 None
 1.20A 2o4lA-5mn5A:
undetectable		 2o4lA-5mn5A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA802_0
(FERROCHELATASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 6 MET A 226
ARG A  29
ARG A 191
VAL A 307
 None
 1.29A 2qd4A-5mn5A:
3.5		 2qd4A-5mn5A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_B_SALB1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 10 THR A 160
ILE A 162
PHE A 100
THR A 313
ILE A 197
 None
 1.31A 2y7wB-5mn5A:
undetectable		 2y7wB-5mn5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 10 LEU A 127
VAL A 129
ILE A 201
LEU A  14
ILE A 197
 None
 0.99A 3jw3A-5mn5A:
undetectable		 3jw3A-5mn5A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 6 ILE A 298
ASP A 213
ILE A 293
GLY A 295
 None
 0.96A 3n3iA-5mn5A:
undetectable		 3n3iA-5mn5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 5 GLY A 106
GLU A 139
GLY A 104
PRO A 135
 GTP  A 401 ( 4.1A)
GTP  A 401 (-2.6A)
GTP  A 401 (-3.4A)
GTP  A 401 (-4.1A)
 1.02A 3onnA-5mn5A:
6.9		 3onnA-5mn5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		3 / 3 GLY A 266
THR A 265
ASN A 299
 None
 0.72A 3v4tD-5mn5A:
undetectable		 3v4tD-5mn5A:
25.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 7 VAL A 129
VAL A 131
ASN A  37
VAL A 189
 None
 0.91A 4e1gB-5mn5A:
undetectable		 4e1gB-5mn5A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 214
PHE A 100
LEU A  14
 None
 0.90A 4f8hA-5mn5A:
undetectable
4f8hB-5mn5A:
undetectable		 4f8hA-5mn5A:
21.99
4f8hB-5mn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 214
PHE A 100
LEU A  14
 None
 0.92A 4f8hB-5mn5A:
undetectable
4f8hC-5mn5A:
undetectable		 4f8hB-5mn5A:
21.99
4f8hC-5mn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 214
PHE A 100
LEU A  14
 None
 0.91A 4f8hC-5mn5A:
undetectable
4f8hD-5mn5A:
undetectable		 4f8hC-5mn5A:
21.99
4f8hD-5mn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 ASP A 199
VAL A 214
PHE A 100
LEU A  14
 None
 0.90A 4f8hD-5mn5A:
undetectable
4f8hE-5mn5A:
undetectable		 4f8hD-5mn5A:
21.99
4f8hE-5mn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 8 VAL A 214
PHE A 100
LEU A  14
ASP A 199
 None
 0.90A 4f8hA-5mn5A:
undetectable
4f8hE-5mn5A:
undetectable		 4f8hA-5mn5A:
21.99
4f8hE-5mn5A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 110
ALA A 113
LEU A  50
THR A  45
ILE A  61
 GTP  A 401 (-3.5A)
None
None
None
None
 1.21A 4hytC-5mn5A:
2.1		 4hytC-5mn5A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_1
(PROTEASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 227
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 0.92A 4njvA-5mn5A:
undetectable		 4njvA-5mn5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 GLY A 227
VAL A 131
GLY A 196
THR A 160
ILE A 162
 None
 1.02A 4njvB-5mn5A:
undetectable		 4njvB-5mn5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 THR A 309
THR A 265
THR A 296
ARG A 191
GLY A 196
 None
 1.44A 4qvpV-5mn5A:
undetectable
4qvpb-5mn5A:
undetectable		 4qvpV-5mn5A:
22.08
4qvpb-5mn5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 THR A 309
THR A 265
THR A 296
ARG A 191
GLY A 196
 None
 1.44A 4qvpH-5mn5A:
undetectable
4qvpN-5mn5A:
undetectable		 4qvpH-5mn5A:
22.08
4qvpN-5mn5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 THR A 309
THR A 265
THR A 296
ARG A 191
GLY A 196
 None
 1.43A 4qvqV-5mn5A:
undetectable
4qvqb-5mn5A:
undetectable		 4qvqV-5mn5A:
22.08
4qvqb-5mn5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 THR A 309
THR A 265
THR A 296
ARG A 191
GLY A 196
 None
 1.43A 4qvqH-5mn5A:
undetectable
4qvqN-5mn5A:
undetectable		 4qvqH-5mn5A:
22.08
4qvqN-5mn5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 11 THR A 309
THR A 265
THR A 296
ARG A 191
GLY A 196
 None
 1.45A 5cz7H-5mn5A:
undetectable
5cz7N-5mn5A:
undetectable		 5cz7H-5mn5A:
22.08
5cz7N-5mn5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A 104
ILE A 217
GLY A 259
GLY A 314
THR A 133
 GTP  A 401 (-3.4A)
None
None
None
None
 1.07A 5eqbA-5mn5A:
undetectable		 5eqbA-5mn5A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		4 / 5 PRO A 115
ALA A 118
ALA A 157
LEU A 161
 None
 0.83A 5jncD-5mn5A:
undetectable		 5jncD-5mn5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 GLY A  18
VAL A 101
GLY A 104
GLY A  20
ASP A 187
 None
None
GTP  A 401 (-3.4A)
GTP  A 401 (-3.4A)
GTP  A 401 (-2.9A)
 1.15A 5x7fA-5mn5A:
4.5		 5x7fA-5mn5A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ALA A 275
GLY A 267
ASP A 280
ALA A 279
PHE A 294
 None
 1.24A 5zvgA-5mn5A:
3.4		 5zvgA-5mn5A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 12 ALA A 275
GLY A 267
ASP A 280
ALA A 279
PHE A 294
 None
 1.23A 5zvgB-5mn5A:
3.2		 5zvgB-5mn5A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 5mn5 CELL DIVISION
PROTEIN FTSZ
(Staphylococcus
aureus) 		5 / 9 SER A 103
VAL A 117
ALA A 118
VAL A  19
GLY A 130
 None
 1.16A 6bklA-5mn5A:
undetectable
6bklB-5mn5A:
undetectable
6bklC-5mn5A:
undetectable
6bklD-5mn5A:
undetectable		 6bklA-5mn5A:
8.81
6bklB-5mn5A:
8.81
6bklC-5mn5A:
8.81
6bklD-5mn5A:
8.81