SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mnj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 5mnj E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 10 VAL C 439
GLY C 448
ILE C 485
PRO C 476
ILE C 440
 None
 1.02A 4njuB-5mnjC:
undetectable		 4njuB-5mnjC:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 5mnj E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 10 VAL C 439
GLY C 448
ILE C 485
PRO C 476
ILE C 440
 None
 1.02A 4njuD-5mnjC:
undetectable		 4njuD-5mnjC:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)		 5mnj E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 10 VAL C 439
GLY C 448
ILE C 485
PRO C 476
ILE C 440
 None
 1.12A 4q1wB-5mnjC:
undetectable		 4q1wB-5mnjC:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5mnj E3 UBIQUITIN-PROTEIN
LIGASE MDM2
(Homo
sapiens) 		5 / 9 VAL C 439
GLY C 448
ILE C 485
PRO C 476
ILE C 440
 None
 1.11A 5kqxB-5mnjC:
undetectable		 5kqxB-5mnjC:
21.50