SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 12 GLY A  71
PHE A  70
MET A   1
LEU A 142
ILE A 149
 None
None
Z90  A 201 (-4.2A)
None
Z90  A 201 ( 4.2A)
 1.26A 1lhuA-5mnwA:
undetectable		 1lhuA-5mnwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 10 ILE A  25
ALA A  54
ALA A  29
ALA A  53
ILE A  14
 None
 1.04A 2aclC-5mnwA:
undetectable		 2aclC-5mnwA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 9 ILE A  66
PHE A  70
LEU A  67
VAL A   5
LEU A   9
 None
None
None
Z90  A 201 (-4.3A)
None
 1.25A 4g1bC-5mnwA:
undetectable		 4g1bC-5mnwA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		3 / 3 VAL A 146
GLY A 148
LYS A 151
 Z90  A 201 ( 3.4A)
None
None
 0.65A 4k50I-5mnwA:
undetectable		 4k50I-5mnwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		5 / 8 PHE A  75
THR A 160
GLN A 156
ILE A 157
GLY A 159
 None
 1.40A 5nzxA-5mnwA:
undetectable		 5nzxA-5mnwA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_F_ADNF503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mnw GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1
(Homo
sapiens) 		4 / 4 GLU A 161
THR A 160
GLU A 185
HIS A 192
 None
 1.32A 5utuF-5mnwA:
undetectable		 5utuF-5mnwA:
10.75