SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5moy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 GLU A1203
GLY A1251
HIS A1253
SER A1264
TYR A1267
 None
 0.54A 1i1eA-5moyA:
0.0		 1i1eA-5moyA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 11 ALA A1194
ILE A1161
VAL A1214
THR A1158
VAL A1125
 None
 1.18A 1rv7A-5moyA:
undetectable
1rv7B-5moyA:
undetectable		 1rv7A-5moyA:
12.02
1rv7B-5moyA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 SER A1027
ILE A 983
ILE A1029
THR A1020
 None
 0.93A 1sbrB-5moyA:
undetectable		 1sbrB-5moyA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		3 / 3 ASN A1103
TRP A1014
GLN A1106
 None
 1.29A 1xoqA-5moyA:
undetectable		 1xoqA-5moyA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		6 / 12 ILE A1053
LEU A 928
ILE A 965
ILE A 878
PHE A1072
VAL A1017
 None
 1.43A 2ygqA-5moyA:
undetectable		 2ygqA-5moyA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 12 ASN A1245
GLY A1244
GLY A1248
ASN A1238
ILE A1247
 None
 1.17A 3k13A-5moyA:
undetectable		 3k13A-5moyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 12 ASN A1245
GLY A1244
GLY A1248
ASN A1238
ILE A1247
 None
 1.17A 3k13B-5moyA:
undetectable		 3k13B-5moyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 12 ASN A1245
GLY A1244
GLY A1248
ASN A1238
ILE A1247
 None
 1.17A 3k13C-5moyA:
undetectable		 3k13C-5moyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 ILE A 984
TYR A 962
THR A 963
ILE A 964
 None
 0.96A 3p50E-5moyA:
undetectable		 3p50E-5moyA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.30A 3t3rB-5moyA:
undetectable		 3t3rB-5moyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_C_9PLC501_1
(CYTOCHROME P450 2A6)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		5 / 9 PHE A1055
PHE A1072
ASN A 966
ILE A1053
THR A 943
 None
 1.31A 3t3rC-5moyA:
undetectable		 3t3rC-5moyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		3 / 3 ASN A1238
ASP A1246
ASN A1268
 None
 0.61A 4agaA-5moyA:
undetectable		 4agaA-5moyA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 ASN A 912
LYS A 911
TYR A 905
LEU A 916
 None
 1.21A 4yv5B-5moyA:
undetectable		 4yv5B-5moyA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 7 GLU A 982
ASN A1021
ILE A1041
VAL A 997
 None
 1.04A 5jh7C-5moyA:
undetectable		 5jh7C-5moyA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 5moy BOTULINUM NEUROTOXIN
TYPE A
(Clostridium
botulinum) 		4 / 5 ASP A1289
TRP A1101
GLY A1292
ASN A1012
 None
 1.37A 5x7pB-5moyA:
6.4		 5x7pB-5moyA:
15.65