SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 115
ILE A 124
PHE A  77
VAL A  87
ILE A  62
 None
 1.08A 1c9hA-5mp2A:
undetectable		 1c9hA-5mp2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 11 SER A 154
HIS A 207
LEU A 166
VAL A 151
ILE A 163
 None
 1.34A 1ee2A-5mp2A:
undetectable		 1ee2A-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 11 SER A 154
HIS A 207
LEU A 166
VAL A 151
ILE A 163
 None
 1.33A 1ee2B-5mp2A:
undetectable		 1ee2B-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 253
ILE A 191
ILE A 160
LEU A 182
ILE A 198
 None
 0.98A 1oipA-5mp2A:
undetectable		 1oipA-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5mp2 CAMELID NANOBODY
VHH04
TYPE II SECRETION
SYSTEM PROTEIN D
(Lama
glama;
Pseudomonas
aeruginosa) 		5 / 12 ILE A 183
LEU A  95
VAL A  89
THR C 102
ILE A  72
 None
 1.14A 2vn0A-5mp2A:
undetectable		 2vn0A-5mp2A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		4 / 8 SER A  70
PHE A  77
VAL A  79
PHE A  65
 None
 1.26A 2wekB-5mp2A:
undetectable		 2wekB-5mp2A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 171
ILE A 191
ALA A 140
HIS A 111
 None
 0.92A 2x0pA-5mp2A:
undetectable		 2x0pA-5mp2A:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04
(Pseudomonas
aeruginosa;
Lama
glama) 		4 / 7 TYR C  59
VAL A  90
TYR C  52
ILE A  55
 None
 1.24A 2xz5B-5mp2C:
undetectable
2xz5E-5mp2C:
undetectable		 2xz5B-5mp2C:
undetectable
2xz5E-5mp2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04
(Pseudomonas
aeruginosa;
Lama
glama) 		4 / 8 ILE A  55
TYR C  59
VAL A  90
TYR C  52
 None
 1.25A 2xz5A-5mp2A:
undetectable
2xz5C-5mp2A:
undetectable		 2xz5A-5mp2A:
undetectable
2xz5C-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04
(Pseudomonas
aeruginosa;
Lama
glama) 		4 / 8 ILE A  55
TYR C  59
VAL A  90
TYR C  52
 None
 1.26A 2xz5C-5mp2A:
undetectable
2xz5D-5mp2A:
undetectable		 2xz5C-5mp2A:
undetectable
2xz5D-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04
(Pseudomonas
aeruginosa;
Lama
glama) 		4 / 7 ILE A  55
TYR C  59
VAL A  90
TYR C  52
 None
 1.24A 2xz5D-5mp2A:
undetectable
2xz5E-5mp2A:
undetectable		 2xz5D-5mp2A:
undetectable
2xz5E-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 12 VAL A  89
SER A  91
THR A 146
ILE A 149
ALA A 181
 None
 1.18A 3ddyA-5mp2A:
undetectable		 3ddyA-5mp2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5mp2 CAMELID NANOBODY
VHH04
(Lama
glama) 		4 / 4 ILE C  53
ARG C  19
ILE C  51
THR C  28
 None
 1.01A 3ia4C-5mp2C:
undetectable		 3ia4C-5mp2C:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 160
LEU A 173
ILE A 184
ILE A 183
ILE A 149
 None
 0.89A 3zosA-5mp2A:
undetectable		 3zosA-5mp2A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		6 / 12 VAL A  89
ILE A  55
GLU A 195
ILE A 198
HIS A 172
VAL A 100
 None
 1.44A 4a97B-5mp2A:
undetectable
4a97C-5mp2A:
undetectable		 4a97B-5mp2A:
14.38
4a97C-5mp2A:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mp2 CAMELID NANOBODY
VHH04
TYPE II SECRETION
SYSTEM PROTEIN D
(Lama
glama;
Pseudomonas
aeruginosa) 		4 / 8 TYR C  59
VAL A  90
TYR C  52
ILE A  55
 None
 1.11A 4aftD-5mp2C:
undetectable
4aftE-5mp2C:
undetectable		 4aftD-5mp2C:
17.37
4aftE-5mp2C:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
CAMELID NANOBODY
VHH04
(Pseudomonas
aeruginosa;
Lama
glama) 		4 / 8 TYR C  59
VAL A  90
TYR C  52
ILE A  55
 None
 1.11A 4bqtC-5mp2C:
undetectable
4bqtD-5mp2C:
undetectable		 4bqtC-5mp2C:
undetectable
4bqtD-5mp2C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 5mp2 CAMELID NANOBODY
VHH04
(Lama
glama) 		4 / 5 TYR C  94
LEU C  81
LEU C  86
ARG C  67
 None
 1.24A 4em2A-5mp2C:
undetectable		 4em2A-5mp2C:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 255
ILE A 244
PRO A 161
LEU A 159
 None
 0.95A 5eb3A-5mp2A:
undetectable		 5eb3A-5mp2A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 115
ILE A 124
PHE A  77
VAL A  87
ILE A  62
 None
 1.11A 5hkgA-5mp2A:
undetectable		 5hkgA-5mp2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 191
ALA A 174
SER A 106
VAL A 148
ILE A 184
 None
 1.08A 5mlmA-5mp2A:
undetectable		 5mlmA-5mp2A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5mp2 TYPE II SECRETION
SYSTEM PROTEIN D
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 160
LEU A 182
ILE A 194
ILE A 198
ILE A 244
 None
 1.03A 5mvmD-5mp2A:
undetectable
5mvmE-5mp2A:
undetectable		 5mvmD-5mp2A:
22.34
5mvmE-5mp2A:
22.34