SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A
(Saccharomyces
cerevisiae) 		4 / 7 LEU M 193
ILE M 197
ALA M 232
ILE M 280
 None
 0.79A 1oniB-5mpaM:
undetectable
1oniC-5mpaM:
undetectable		 1oniB-5mpaM:
17.01
1oniC-5mpaM:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A
(Saccharomyces
cerevisiae) 		3 / 3 SER M 123
VAL M 148
LEU M  78
 None
 0.72A 1yajG-5mpaM:
undetectable		 1yajG-5mpaM:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A
(Saccharomyces
cerevisiae) 		5 / 12 ILE M 347
ALA M 196
LEU M 193
ILE M 212
PRO M 215
 None
 1.12A 3ozwB-5mpaM:
undetectable		 3ozwB-5mpaM:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A
(Saccharomyces
cerevisiae) 		4 / 8 THR M 226
GLY M 185
GLY M 184
VAL M 183
 ATP  M 501 (-4.6A)
None
ATP  M 501 (-3.8A)
ATP  M 501 ( 4.4A)
 0.51A 4qvvK-5mpaM:
23.4
4qvvL-5mpaM:
35.0		 4qvvK-5mpaM:
19.77
4qvvL-5mpaM:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A
(Saccharomyces
cerevisiae) 		4 / 8 THR M 226
GLY M 185
GLY M 184
VAL M 183
 ATP  M 501 (-4.6A)
None
ATP  M 501 (-3.8A)
ATP  M 501 ( 4.4A)
 0.50A 4qvvY-5mpaM:
16.9
4qvvZ-5mpaM:
34.9		 4qvvY-5mpaM:
19.77
4qvvZ-5mpaM:
17.28