SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpd'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_RALA600_2 (ESTROGEN RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	4 / 6	LEU S 372 HIS T 132 LEU T 110 LEU T 113	None	0.88A	1errA-5mpdS: undetectable	1errA-5mpdS: 19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FOH_A_IPHA802_0 (PHENOL HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	ASP R 365 ILE R 381 ARG R 383 TYR S 399 GLY R 369	None	0.94A	1fohA-5mpdR: undetectable	1fohA-5mpdR: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FOH_B_IPHB802_0 (PHENOL HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	ASP R 365 ILE R 381 ARG R 383 TYR S 399 GLY R 369	None	0.97A	1fohB-5mpdR: undetectable	1fohB-5mpdR: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FOH_C_IPHC802_0 (PHENOL HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	ASP R 365 ILE R 381 ARG R 383 TYR S 399 GLY R 369	None	0.98A	1fohC-5mpdR: undetectable	1fohC-5mpdR: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FOH_D_IPHD802_0 (PHENOL HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	ASP R 365 ILE R 381 ARG R 383 TYR S 399 GLY R 369	None	0.98A	1fohD-5mpdR: undetectable	1fohD-5mpdR: 20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_A_117A2_1 (HMG-COA REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 8	SER O 390 SER T 269 ASN S 469 ASP T 265	None	1.23A	1hwkA-5mpdO: undetectable	1hwkA-5mpdO: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_C_117C4_1 (HMG-COA REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 8	SER O 390 SER T 269 ASN S 469 ASP T 265	None	1.23A	1hwkC-5mpdO: undetectable	1hwkC-5mpdO: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HWK_D_117D3_2 (HMG-COA REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 8	SER O 390 SER T 269 ASN S 469 ASP T 265	None	1.21A	1hwkD-5mpdO: undetectable	1hwkD-5mpdO: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JFF_B_TA1B601_1 (TUBULIN BETA CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	1jffB-5mpdQ: undetectable	1jffB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JQD_A_HSMA600_1 (HISTAMINE N-METHYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 7	PHE N 399 TRP N 362 TRP N 742 ASN N 361	None	1.41A	1jqdA-5mpdN: undetectable	1jqdA-5mpdN: 15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JU6_C_LYAC315_1 (THYMIDYLATE SYNTHASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 10	ASN O 117 ASP O 124 LEU O  76 GLY O 125 PHE O 106	None	1.49A	1ju6C-5mpdO: undetectable	1ju6C-5mpdO: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JUJ_A_LYAA315_1 (THYMIDYLATE SYNTHASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 10	ASN O 117 ASP O 124 LEU O  76 GLY O 125 PHE O 106	None	1.45A	1jujA-5mpdO: undetectable	1jujA-5mpdO: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JUJ_B_LYAB315_1 (THYMIDYLATE SYNTHASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 10	ASN O 117 ASP O 124 LEU O  76 GLY O 125 PHE O 106	None	1.45A	1jujB-5mpdO: undetectable	1jujB-5mpdO: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JUJ_C_LYAC315_1 (THYMIDYLATE SYNTHASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 10	ASN O 117 ASP O 124 LEU O  76 GLY O 125 PHE O 106	None	1.45A	1jujC-5mpdO: undetectable	1jujC-5mpdO: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JUJ_D_LYAD315_1 (THYMIDYLATE SYNTHASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 10	ASN O 117 ASP O 124 LEU O  76 GLY O 125 PHE O 106	None	1.45A	1jujD-5mpdO: undetectable	1jujD-5mpdO: 21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KI2_B_GA2B2_1 (THYMIDINE KINASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	5 / 12	GLU P 367 ILE P 353 TYR P 357 ARG P 310 ARG P 364	None	1.21A	1ki2B-5mpdP: 0.0	1ki2B-5mpdP: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1KIA_A_ACTA294_0 (GLYCINE N-METHYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	4 / 6	TYR S 188 ASN S 235 ARG S 271 TYR S 275	None	1.48A	1kiaA-5mpdS: undetectable	1kiaA-5mpdS: 19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7F_A_BCZA801_0 (NEURAMINIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	LEU O  11 ARG O  15 GLU O  30 GLU O  35 GLU O  34	None	1.11A	1l7fA-5mpdO: undetectable	1l7fA-5mpdO: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7G_A_BCZA801_0 (NEURAMINIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	LEU O  11 ARG O  15 GLU O  30 GLU O  35 GLU O  34	None	1.13A	1l7gA-5mpdO: undetectable	1l7gA-5mpdO: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L7H_A_BCZA801_0 (NEURAMINIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	LEU O  11 ARG O  15 GLU O  30 GLU O  35 GLU O  34	None	1.12A	1l7hA-5mpdO: undetectable	1l7hA-5mpdO: 19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_B_SAMB402_1 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 5	VAL O  78 SER O  77 ASP O 110 GLN O 105	None	1.24A	1n2xB-5mpdO: undetectable	1n2xB-5mpdO: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_A_SAMA293_1 (GLYCINE N-METHYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	3 / 3	ARG U 254 ASP U 243 ASN U 238	None	0.74A	1nbhA-5mpdU: undetectable	1nbhA-5mpdU: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NBH_D_SAMD3293_1 (GLYCINE N-METHYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	3 / 3	ARG U 254 ASP U 243 ASN U 238	None	0.71A	1nbhD-5mpdU: undetectable	1nbhD-5mpdU: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P7L_C_SAMC685_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	ALA N 702 ASP N 677 ILE N 678 ILE N 638	None	0.89A	1p7lD-5mpdN: undetectable	1p7lD-5mpdN: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P7L_C_SAMC885_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	ALA N 702 ASP N 677 ILE N 678 ILE N 638	None	0.89A	1p7lC-5mpdN: undetectable	1p7lC-5mpdN: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_C_NCAC339_0 (ADP-RIBOSYL CYCLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	3 / 3	GLU P 319 ASN P 323 TRP P 338	None	1.00A	1r15C-5mpdP: undetectable	1r15C-5mpdP: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_D_NCAD349_0 (ADP-RIBOSYL CYCLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	3 / 3	GLU P 319 ASN P 323 TRP P 338	None	0.95A	1r15D-5mpdP: undetectable	1r15D-5mpdP: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_E_NCAE359_0 (ADP-RIBOSYL CYCLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	3 / 3	GLU P 319 ASN P 323 TRP P 338	None	0.98A	1r15E-5mpdP: undetectable	1r15E-5mpdP: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R15_F_NCAF369_0 (ADP-RIBOSYL CYCLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	3 / 3	GLU P 319 ASN P 323 TRP P 338	None	0.99A	1r15F-5mpdP: undetectable	1r15F-5mpdP: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_A_SAMA385_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	ALA N 702 ASP N 677 ILE N 678 ILE N 638	None	0.91A	1rg9B-5mpdN: undetectable	1rg9B-5mpdN: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_B_SAMB485_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	ALA N 702 ASP N 677 ILE N 678 ILE N 638	None	0.92A	1rg9A-5mpdN: undetectable	1rg9A-5mpdN: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_C_SAMC585_1 (S-ADENOSYLMETHIONINE SYNTHETASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	ALA N 702 ASP N 677 ILE N 678 ILE N 638	None	0.90A	1rg9D-5mpdN: undetectable	1rg9D-5mpdN: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG9_C_SAMC685_0 (S-ADENOSYLMETHIONINE SYNTHETASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	ALA N 702 ASP N 677 ILE N 678 ILE N 638	None	0.90A	1rg9C-5mpdN: undetectable	1rg9C-5mpdN: 17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V55_C_CHDC3271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE III CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 7	LEU O 254 GLN O 253 PHE O 252 LEU O 222	None	1.05A	1v55C-5mpdO: 2.5 1v55J-5mpdO: undetectable	1v55C-5mpdO: 20.20 1v55J-5mpdO: 10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Y4L_B_SVRB301_1 (PHOSPHOLIPASE A2 HOMOLOG 2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	GLY N 372 GLY N 407 LEU N 448 GLY N 449 PRO N 391	None	0.81A	1y4lA-5mpdN: undetectable	1y4lA-5mpdN: 7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZQ9_A_SAMA4000_1 (PROBABLE DIMETHYLADENOSINE TRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	GLY N 723 GLU N 718 ASN N 231	None	0.63A	1zq9A-5mpdN: undetectable	1zq9A-5mpdN: 13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AVS_B_MK1B902_3 (POL POLYPROTEIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 12	GLY R 165 ALA R 166 ASP R 169 ILE R 135 ILE R 162	None	1.15A	2avsB-5mpdR: undetectable	2avsB-5mpdR: 12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_A_SAMA301_1 (CEPHALOSPORIN HYDROXYLASE CMCI)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	3 / 3	LYS Q  90 ASP Q  34 ASP Q  32	None	1.13A	2br4A-5mpdQ: undetectable	2br4A-5mpdQ: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_C_SAMC301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	LEU N 591 GLY N 620 ASP N 647 ALA N 622 ALA N 656	None	1.10A	2br4C-5mpdN: undetectable	2br4C-5mpdN: 12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DTJ_A_THRA401_0 (ASPARTOKINASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	GLY N 292 GLN N 766 ASN N 288 ILE N 289	None	0.81A	2dtjA-5mpdN: undetectable 2dtjB-5mpdN: undetectable	2dtjA-5mpdN: 11.43 2dtjB-5mpdN: 11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYS_P_CHDP310_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	4 / 7	LEU P 181 GLN P 183 PHE P 179 LEU P 216	None	1.04A	2dysP-5mpdP: undetectable 2dysW-5mpdP: undetectable	2dysP-5mpdP: 19.87 2dysW-5mpdP: 8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIJ_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 7	LEU O 254 GLN O 253 PHE O 252 LEU O 222	None	1.07A	2eijC-5mpdO: 2.5 2eijJ-5mpdO: undetectable	2eijC-5mpdO: 20.20 2eijJ-5mpdO: 10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIM_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 7	LEU O 254 GLN O 253 PHE O 252 LEU O 222	None	1.07A	2eimC-5mpdO: 2.4 2eimJ-5mpdO: undetectable	2eimC-5mpdO: 20.20 2eimJ-5mpdO: 10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIN_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	4 / 6	LEU P 181 GLN P 183 PHE P 179 LEU P 216	None	1.06A	2einP-5mpdP: undetectable 2einW-5mpdP: undetectable	2einP-5mpdP: 19.87 2einW-5mpdP: 8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIN_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 6	LEU O 254 GLN O 253 PHE O 252 LEU O 222	None	1.00A	2einP-5mpdO: 2.5 2einW-5mpdO: undetectable	2einP-5mpdO: 20.20 2einW-5mpdO: 10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_D_TACD2888_1 (ELONGATION FACTOR EF-TU)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 5	SER O 202 THR O  46 SER O 204 ASP O  50	None	1.48A	2hdnB-5mpdO: undetectable 2hdnC-5mpdO: undetectable 2hdnD-5mpdO: undetectable	2hdnB-5mpdO: 21.65 2hdnC-5mpdO: 5.68 2hdnD-5mpdO: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HXF_B_TA1B601_1 (TUBULIN BETA CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	2hxfB-5mpdQ: undetectable	2hxfB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HXH_B_TA1B601_1 (TUBULIN BETA CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	2hxhB-5mpdQ: undetectable	2hxhB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JFA_A_RALA600_2 (ESTROGEN RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	4 / 5	LEU P 293 ASP P 287 LEU P 322 HIS P 263	None	1.25A	2jfaA-5mpdP: undetectable	2jfaA-5mpdP: 18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2JJ8_C_AZZC1211_1 (DEOXYNUCLEOSIDE KINASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	VAL N 574 LEU N 540 MET N 539 ALA N 556 PHE N 553	None	1.48A	2jj8C-5mpdN: undetectable	2jj8C-5mpdN: 11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2KI5_B_AC2B2_1 (PROTEIN (THYMIDINE KINASE))	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	5 / 12	GLU P 367 ILE P 353 TYR P 357 ARG P 310 ARG P 364	None	1.11A	2ki5B-5mpdP: undetectable	2ki5B-5mpdP: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_B_SAMB201_0 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	GLY N 592 ALA N 590 LEU N 571 VAL N 602 THR N 601	None	0.97A	2nyuB-5mpdN: undetectable	2nyuB-5mpdN: 12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_A_SAMA300_1 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	SER R 196 HIS R 217 ASP R 183	None	0.80A	2oxtA-5mpdR: undetectable	2oxtA-5mpdR: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P4N_B_TA1B601_1 (TUBULIN BETA CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	2p4nB-5mpdQ: undetectable	2p4nB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PGZ_D_COCD401_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	4 / 6	TYR R 321 TYR R  24 TYR R 252 ILE R 249	None	1.36A	2pgzD-5mpdR: undetectable 2pgzE-5mpdR: undetectable	2pgzD-5mpdR: 18.74 2pgzE-5mpdR: 18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PNC_A_CLUA808_1 (COPPER AMINE OXIDASE, LIVER ISOZYME)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	4 / 7	ALA Q 258 TYR Q 291 TYR Q 255 HIS Q 247	None	1.46A	2pncA-5mpdQ: undetectable	2pncA-5mpdQ: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_B_CHDB501_0 (FERROCHELATASE, MITOCHONDRIAL)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 11	LEU N 163 SER N 210 LEU N 190 VAL N 228 VAL N 197	None	1.04A	2po5B-5mpdN: undetectable	2po5B-5mpdN: 16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PRG_B_BRLB2_1 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	5 / 12	PHE S  76 LEU S 183 VAL S 163 LEU S  34 LEU S  57	None	1.44A	2prgB-5mpdS: undetectable	2prgB-5mpdS: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q63_A_1UNA1001_2 (PROTEASE RETROPEPSIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	3 / 3	ARG S 480 ASN S 469 THR U 269	None	0.84A	2q63A-5mpdS: undetectable	2q63A-5mpdS: 11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEU_B_ACTB141_0 (PUTATIVE CARBOXYMUCONOLACTONE DECARBOXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	PRO S 482 ASN U 280 ARG U 283	None	0.93A	2qeuB-5mpdS: 2.0	2qeuB-5mpdS: 13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R2V_D_ACTD36_0 (GCN4 LEUCINE ZIPPER)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	3 / 3	SER Q 182 TYR Q 185 HIS Q 186	None	0.45A	2r2vD-5mpdQ: undetectable	2r2vD-5mpdQ: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R2V_D_ACTD36_0 (GCN4 LEUCINE ZIPPER)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	3 / 3	SER Q 245 TYR Q 246 HIS Q 247	None	0.77A	2r2vD-5mpdQ: undetectable	2r2vD-5mpdQ: 6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0M_D_KLND1498_1 (CYTOCHROME P450 3A4)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 11	SER R 254 ILE R 289 ALA R 285 THR R 283 GLU R 275	None	1.26A	2v0mD-5mpdR: undetectable	2v0mD-5mpdR: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W3B_B_FOLB401_1 (DIHYDROFOLATE REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN10 (Saccharomyces cerevisiae)	3 / 3	GLU W 166 GLN W 108 ARG W 101	None	0.85A	2w3bB-5mpdW: undetectable	2w3bB-5mpdW: 23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WBE_B_TA1B1439_1 (TUBULIN BETA-2B CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	2wbeB-5mpdQ: undetectable	2wbeB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_A_QPSA1050_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	ASP O   8 LEU O  11 PHE O  69 TYR O  33 PHE O  65	None	1.27A	2x2iA-5mpdO: undetectable	2x2iA-5mpdO: 16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X7H_A_PFNA1374_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN10 (Saccharomyces cerevisiae)	4 / 6	PRO W 117 SER W 116 GLU W  14 TYR W  15	None	1.44A	2x7hA-5mpdW: 2.0	2x7hA-5mpdW: 22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_C_ZMRC1776_2 (NEURAMINIDASE A)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	ASP N 677 ILE N 678 GLN N 703 TYR N 788	None	1.43A	2ya7C-5mpdN: undetectable	2ya7C-5mpdN: 19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A50_E_VD3E2001_1 (VITAMIN D HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	5 / 12	THR P 304 LEU P 268 ASN P 278 LEU P 299 LEU P 270	None	1.28A	3a50E-5mpdP: undetectable	3a50E-5mpdP: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ADS_B_IMNB3_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 12	ARG R 206 ILE R 241 LEU R 172 VAL R 194 ILE R 198	None	1.18A	3adsB-5mpdR: undetectable	3adsB-5mpdR: 21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_C_CHDC271_0 (CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	4 / 7	LEU P 181 GLN P 183 PHE P 179 LEU P 216	None	1.02A	3ag2C-5mpdP: undetectable	3ag2C-5mpdP: 19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	4 / 7	LEU P 181 GLN P 183 PHE P 179 LEU P 216	None	0.99A	3ag2P-5mpdP: undetectable 3ag2W-5mpdP: undetectable	3ag2P-5mpdP: 19.87 3ag2W-5mpdP: 8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_A_SAMA238_1 (N,N-DIMETHYLTRANSFER ASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	TYR N 857 GLU N 669 ASP N 310	None	0.78A	3bxoA-5mpdN: undetectable	3bxoA-5mpdN: 14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_A_SAMA238_1 (N,N-DIMETHYLTRANSFER ASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	TYR Q 255 GLU Q 289 ASP P 154	None	0.63A	3bxoA-5mpdQ: undetectable	3bxoA-5mpdQ: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_B_SAMB238_1 (N,N-DIMETHYLTRANSFER ASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	TYR N 857 GLU N 669 ASP N 310	None	0.77A	3bxoB-5mpdN: undetectable	3bxoB-5mpdN: 14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BXO_B_SAMB238_1 (N,N-DIMETHYLTRANSFER ASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	TYR Q 255 GLU Q 289 ASP P 154	None	0.60A	3bxoB-5mpdQ: undetectable	3bxoB-5mpdQ: 21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3COT_A_STRA1501_1 (3-OXO-5-BETA-STEROID 4-DEHYDROGENASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	4 / 7	TYR S 421 TYR T 157 GLU T 188 TRP T 226	None	1.47A	3cotA-5mpdS: undetectable	3cotA-5mpdS: 22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D90_A_NOGA1001_1 (PROGESTERONE RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	LEU O 234 LEU O 255 ASN O 256 LEU O 254 MET O 294	None	1.24A	3d90A-5mpdO: undetectable	3d90A-5mpdO: 21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DCO_B_TA1B601_1 (BOVINE BETA TUBULIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	3dcoB-5mpdQ: undetectable	3dcoB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DLC_A_SAMA220_0 (PUTATIVE S-ADENOSYL-L-METHION INE-DEPENDENT METHYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	TYR N 526 GLY N 732 PHE N 736 SER N 737 SER N 752	None	1.38A	3dlcA-5mpdN: undetectable	3dlcA-5mpdN: 13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DZY_D_BRLD478_2 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR GAMMA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 4	ILE O 291 GLN O 289 ILE O 270 LEU O 334	None	1.32A	3dzyD-5mpdO: undetectable	3dzyD-5mpdO: 24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EBZ_B_017B201_2 (PROTEASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 11	GLY N 698 ALA N 699 GLY N 704 ILE N 705 ILE N 678	None	0.78A	3ebzB-5mpdN: undetectable	3ebzB-5mpdN: 7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EDL_B_TA1B601_1 (BETA TUBULIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.13A	3edlB-5mpdQ: undetectable	3edlB-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRB_X_TOPX300_1 (DIHYDROFOLATE REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	5 / 11	LEU T 208 LEU T 200 VAL T 233 SER S 424 THR T 217	None	1.12A	3frbX-5mpdT: undetectable	3frbX-5mpdT: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRE_X_TOPX300_1 (DIHYDROFOLATE REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN10 (Saccharomyces cerevisiae)	5 / 9	ALA W  94 LEU W  91 LEU W 132 VAL W 137 ILE W 158	None	1.25A	3freX-5mpdW: undetectable	3freX-5mpdW: 19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRQ_A_ERYA195_1 (REPRESSOR PROTEIN MPHR(A))	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN12 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	ASN T  93 ASN S 207 HIS S 191 ALA S 195	None	1.30A	3frqA-5mpdT: undetectable	3frqA-5mpdT: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GCS_A_BAXA401_2 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN10 (Saccharomyces cerevisiae)	4 / 6	VAL W   7 LEU W   3 ILE W  93 ILE W 110	None	0.89A	3gcsA-5mpdW: undetectable	3gcsA-5mpdW: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IZ0_B_TA1B820_1 (BETA TUBULIN, CHAIN B FROM PDB 1JFF)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.12A	3iz0B-5mpdQ: undetectable	3iz0B-5mpdQ: 20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JB2_A_SAMA1101_1 (STRUCTURAL PROTEIN VP3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	GLU S 444 ASP R 382 ASP S 440	None	0.77A	3jb2A-5mpdS: 2.2	3jb2A-5mpdS: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3K37_A_BCZA468_0 (NEURAMINIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	LEU O  11 ARG O  15 GLU O  30 GLU O  35 GLU O  34	None	1.10A	3k37A-5mpdO: undetectable	3k37A-5mpdO: 20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDR_B_GJZB506_1 (CHOLESTEROL 24-HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	PHE N 242 ILE N 257 ALA N 258 ALA N 265	None	1.01A	3mdrB-5mpdN: undetectable	3mdrB-5mpdN: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NMU_F_SAMF228_0 (FIBRILLARIN-LIKE RRNA/TRNA 2'-O-METHYLTRANSFERA SE NOP5/NOP56 RELATED PROTEIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	GLU S 474 TYR S 475 GLY R 418 ALA R 419 SER S 478	None	1.35A	3nmuA-5mpdS: undetectable 3nmuF-5mpdS: undetectable	3nmuA-5mpdS: 22.57 3nmuF-5mpdS: 17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NNE_G_ACTG601_0 (CHOLINE OXIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	ALA N 446 ILE N 426 VAL N 439 ASN N 430	None	1.22A	3nneG-5mpdN: undetectable	3nneG-5mpdN: 20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OZK_A_T44A128_1 (TRANSTHYRETIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 9	LEU O  83 THR O 174 LEU O  86 SER O  95 THR O 136	None	1.44A	3ozkA-5mpdO: undetectable	3ozkA-5mpdO: 13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXV_D_MTXD2000_2 (ANTI-METHOTREXATE CDR1-4 GRAFT VHH)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	LEU R 154 ARG R 209 ASN R  23	None	0.73A	3qxvD-5mpdR: undetectable	3qxvD-5mpdR: 15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S45_B_478B201_2 (PROTEASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 11	GLY N 698 ALA N 699 GLY N 704 ILE N 705 ILE N 678	None	0.77A	3s45B-5mpdN: undetectable	3s45B-5mpdN: 7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S53_A_017A201_1 (PROTEASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 9	GLY N 698 ALA N 699 GLY N 704 ILE N 705 ILE N 678	None	0.94A	3s53A-5mpdN: undetectable	3s53A-5mpdN: 6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S56_A_ROCA201_1 (PROTEASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	GLY N 698 ALA N 699 GLY N 704 ILE N 705 ILE N 678	None	0.79A	3s56A-5mpdN: undetectable	3s56A-5mpdN: 6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TMZ_A_06XA503_1 (CYTOCHROME P450 2B4)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 11	ILE N 874 ILE N 759 PHE N 884 ILE N 882 VAL N 868	None	1.07A	3tmzA-5mpdN: undetectable	3tmzA-5mpdN: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TNE_B_RITB401_2 (SECRETED ASPARTIC PROTEASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 7	ILE N 882 THR N 757 THR N 756 TYR N 299	None	0.69A	3tneB-5mpdN: undetectable	3tneB-5mpdN: 17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH504_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	3 / 3	LYS S  36 GLU S  40 TRP S  54	None	1.19A	3v4tH-5mpdS: undetectable	3v4tH-5mpdS: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V5V_A_ACTA511_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 4	ASN N 681 PHE N 682 SER N 684 GLN N 703	None	1.37A	3v5vA-5mpdN: undetectable	3v5vA-5mpdN: 19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VYW_C_SAMC401_0 (MNMC2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	LEU N 517 GLY N 516 ASN N 512 ALA N 446 LEU N 443	None	1.06A	3vywC-5mpdN: undetectable	3vywC-5mpdN: 15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_D_ZPCD1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	4 / 8	VAL Q 302 MET Q 271 ILE Q 270 GLU Q 322	None	0.86A	4a97C-5mpdQ: 4.3	4a97C-5mpdQ: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_E_ZPCE1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	4 / 8	VAL Q 302 MET Q 271 ILE Q 270 GLU Q 322	None	0.95A	4a97D-5mpdQ: 2.2	4a97D-5mpdQ: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_H_ZPCH1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	4 / 8	VAL Q 302 MET Q 271 ILE Q 270 GLU Q 322	None	0.82A	4a97G-5mpdQ: 2.2	4a97G-5mpdQ: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_J_ZPCJ1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	4 / 8	VAL Q 302 MET Q 271 ILE Q 270 GLU Q 322	None	0.86A	4a97I-5mpdQ: 2.3	4a97I-5mpdQ: 21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AGA_A_ACTA1131_0 (LYSOZYME C)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	ASN U 294 ASP U 290 ASN S 490	None	0.62A	4agaA-5mpdU: undetectable	4agaA-5mpdU: 14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DTZ_B_LDPB501_1 (CYTOCHROME P450 BM3 VARIANT 8C8)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 6	PHE O  26 ALA O  18 ALA O  52 LEU O  57	None	1.08A	4dtzB-5mpdO: undetectable	4dtzB-5mpdO: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DTZ_B_LDPB501_1 (CYTOCHROME P450 BM3 VARIANT 8C8)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 6	PHE O  26 ALA O  18 LEU O  57 THR O  55	None	1.12A	4dtzB-5mpdO: undetectable	4dtzB-5mpdO: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E3A_B_ADNB500_1 (SUGAR KINASE PROTEIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	ILE N 309 GLY N 710 GLY N 709 THR N 343 GLY N 342	None	0.56A	4e3aB-5mpdN: undetectable	4e3aB-5mpdN: 16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I41_A_MIXA500_2 (SERINE/THREONINE-PRO TEIN KINASE PIM-1)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	4 / 4	LEU Q 419 LEU U 261 GLN R 406 GLU Q 414	None	1.17A	4i41A-5mpdQ: undetectable	4i41A-5mpdQ: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IB4_A_ERMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 26S PROTEASOME REGULATORY SUBUNIT RPN7 26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	4 / 7	ASP Q 424 ASN U 270 GLN R 415 LEU R 414	None	1.13A	4ib4A-5mpdQ: undetectable	4ib4A-5mpdQ: 21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MX0_A_BCZA513_0 (NEURAMINIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	5 / 12	LEU O  11 ARG O  15 GLU O  30 GLU O  35 GLU O  34	None	1.14A	4mx0A-5mpdO: undetectable	4mx0A-5mpdO: 19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PO0_A_NPSA603_1 (SERUM ALBUMIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	5 / 10	ASN S 159 LEU S 146 ASN S  91 LEU S  92 VAL S 142	None	1.17A	4po0A-5mpdS: 2.3	4po0A-5mpdS: 23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWJ_B_30ZB201_1 (TRANSTHYRETIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 7	LEU O  83 THR O 174 LEU O  86 THR O 136	None	0.96A	4pwjB-5mpdO: undetectable	4pwjB-5mpdO: 16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QC6_B_KANB201_2 (BIFUNCTIONAL AAC/APH)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	3 / 3	LEU Q 343 ASP Q 340 TYR Q 339	None	0.54A	4qc6B-5mpdQ: undetectable	4qc6B-5mpdQ: 14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4U14_A_0HKA2000_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M3,ENDOLYSIN,MUSCARI NIC ACETYLCHOLINE RECEPTOR M3)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	4 / 4	ASN R  23 LEU R 154 PHE R 179 TYR R 186	None	1.40A	4u14A-5mpdR: 0.0	4u14A-5mpdR: 21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4UCK_B_SAMB2409_0 (RNA-DIRECTED RNA POLYMERASE L)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	THR N 419 GLY N 451 GLY N 449 LEU N 490 THR N 727	None	1.11A	4uckB-5mpdN: undetectable	4uckB-5mpdN: 19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y8W_B_STRB603_1 (CYTOCHROME P450 21-HYDROXYLASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae)	5 / 12	VAL P 393 VAL P 384 LEU P 383 ILE P 389 LEU P 369	None	1.06A	4y8wB-5mpdP: undetectable	4y8wB-5mpdP: 24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DNU_A_BEZA319_0 (SHKAI2IB)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 5	GLN O 211 ILE O 242 ILE O 238 TYR O 248	None	0.78A	5dnuA-5mpdO: undetectable	5dnuA-5mpdO: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DNV_A_BEZA304_0 (SHKAI2IB)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	4 / 5	GLN O 211 ILE O 242 ILE O 238 TYR O 248	None	0.79A	5dnvA-5mpdO: undetectable	5dnvA-5mpdO: 21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DSG_B_0HKB1201_2 (MUSCARINIC ACETYLCHOLINE RECEPTOR M4,ENDOLYSIN,ENDOLYS IN,MUSCARINIC ACETYLCHOLINE RECEPTOR M4)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	3 / 3	ASP S 240 ASN S 235 PHE S 274	None	0.65A	5dsgB-5mpdS: undetectable	5dsgB-5mpdS: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_R_BEZR801_1 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	4 / 8	SER R 254 ALA R 253 LEU R 276 LEU R 279	None	0.97A	5dzkd-5mpdR: 2.3 5dzkr-5mpdR: undetectable	5dzkd-5mpdR: 21.19 5dzkr-5mpdR: 6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_Y_BEZY801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 5	PHE N 137 ILE N 165 GLY N 160 ILE N 141	None	0.85A	5dzkd-5mpdN: undetectable 5dzkk-5mpdN: undetectable 5dzky-5mpdN: undetectable	5dzkd-5mpdN: 12.32 5dzkk-5mpdN: 13.12 5dzky-5mpdN: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HNW_B_TA1B902_1 (TUBULIN BETA-2B CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.00A	5hnwB-5mpdQ: undetectable	5hnwB-5mpdQ: 20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HNY_B_TA1B601_1 (TUBULIN BETA-2B CHAIN)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	5 / 12	VAL Q 278 ASP Q 277 LEU Q 342 LEU Q 338 THR Q 341	None	1.05A	5hnyB-5mpdQ: undetectable	5hnyB-5mpdQ: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_A_BEZA301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 10	GLY N 732 SER N 750 LEU N 751 LEU N 452 TYR N 406	None	1.06A	5hwkA-5mpdN: undetectable	5hwkA-5mpdN: 13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_B_BEZB301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 10	GLY N 732 SER N 750 LEU N 751 LEU N 452 TYR N 406	None	1.07A	5hwkB-5mpdN: undetectable	5hwkB-5mpdN: 13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGJ_A_CTYA402_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 12	ILE R 271 GLU R 332 ALA R 227 ALA R 228 VAL R 232	None	0.98A	5igjA-5mpdR: undetectable	5igjA-5mpdR: 18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IKT_B_TLFB601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	TYR R 213 TYR R  62 SER R  27	None	0.93A	5iktB-5mpdR: undetectable	5iktB-5mpdR: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_A_1GNA607_1 (PHIAB6 TAILSPIKE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	THR R 244 SER R 248 TYR R 252	None	0.84A	5jsdA-5mpdR: undetectable	5jsdA-5mpdR: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB618_1 (PHIAB6 TAILSPIKE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	THR R 244 SER R 248 TYR R 252	None	0.84A	5jsdB-5mpdR: undetectable	5jsdB-5mpdR: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_C_1GNC608_1 (PHIAB6 TAILSPIKE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	THR R 244 SER R 248 TYR R 252	None	0.84A	5jsdC-5mpdR: undetectable	5jsdC-5mpdR: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_A_1GNA608_1 (PHIAB6 TAILSPIKE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	THR R 244 SER R 248 TYR R 252	None	0.84A	5jseA-5mpdR: undetectable	5jseA-5mpdR: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_B_1GNB611_1 (PHIAB6 TAILSPIKE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	THR R 244 SER R 248 TYR R 252	None	0.83A	5jseB-5mpdR: undetectable	5jseB-5mpdR: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_C_1GNC611_1 (PHIAB6 TAILSPIKE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	3 / 3	THR R 244 SER R 248 TYR R 252	None	0.83A	5jseC-5mpdR: undetectable	5jseC-5mpdR: 22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JVZ_A_FLPA601_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 12	LEU R 243 LEU R 172 TYR R 321 GLY R 215 LEU R 191	None	1.03A	5jvzA-5mpdR: undetectable	5jvzA-5mpdR: 20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KI6_A_IPHA901_0 (PROTEIN ARGONAUTE-2)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN6 (Saccharomyces cerevisiae)	4 / 5	LEU Q  31 TYR Q  27 LEU Q  61 TYR Q  65	None	1.19A	5ki6A-5mpdQ: undetectable	5ki6A-5mpdQ: 20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5LJB_A_RTLA201_0 (RETINOL-BINDING PROTEIN 1)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	5 / 12	PHE S 309 ALA S 270 SER S 277 PHE S 273 ILE S 297	None	1.35A	5ljbA-5mpdS: undetectable	5ljbA-5mpdS: 14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NO9_D_95ZD302_1 (25 KDA PROTEIN ELICITOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN12 26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	4 / 7	GLY S 245 ASP S 375 HIS T 132 ASN S 243	None	1.09A	5no9D-5mpdS: undetectable	5no9D-5mpdS: 9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ODH_G_ACTG710_0 (HETERODISULFIDE REDUCTASE, SUBUNIT A)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 26S PROTEASOME REGULATORY SUBUNIT RPN5 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	ARG P 364 ILE P 360 TYR P 357 ILE O 341	None	1.46A	5odhG-5mpdP: undetectable	5odhG-5mpdP: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_A_CUA602_0 (THIOCYANATE DEHYDROGENASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	3 / 3	LYS S  23 HIS S  19 HIS S  20	None	0.99A	5oexA-5mpdS: undetectable	5oexA-5mpdS: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_B_CUB602_0 (THIOCYANATE DEHYDROGENASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	3 / 3	LYS S  23 HIS S  19 HIS S  20	None	1.01A	5oexB-5mpdS: undetectable	5oexB-5mpdS: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_C_CUC603_0 (THIOCYANATE DEHYDROGENASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	3 / 3	LYS S  23 HIS S  19 HIS S  20	None	0.96A	5oexC-5mpdS: undetectable	5oexC-5mpdS: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OEX_D_CUD603_0 (THIOCYANATE DEHYDROGENASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	3 / 3	LYS S  23 HIS S  19 HIS S  20	None	0.97A	5oexD-5mpdS: undetectable	5oexD-5mpdS: 20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SXQ_B_NIZB808_1 (CATALASE-PEROXIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	4 / 8	VAL U 207 GLY U 227 LEU U 226 THR U 224	None	1.08A	5sxqB-5mpdU: undetectable	5sxqB-5mpdU: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5SYJ_A_NIZA809_1 (CATALASE-PEROXIDASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae)	4 / 8	VAL U 207 GLY U 227 LEU U 226 THR U 224	None	1.07A	5syjA-5mpdU: undetectable	5syjA-5mpdU: 18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VLM_E_CVIE301_0 (REGULATORY PROTEIN TETR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	5 / 12	ALA N 518 LEU N 535 ILE N 536 ARG N 570 TYR N 559	None	1.28A	5vlmE-5mpdN: 1.9	5vlmE-5mpdN: 10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZBD_A_TRPA501_0 (FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 10	LEU R 364 TYR R 338 ASP R 367 VAL R 359 GLY R 358	None	1.46A	5zbdA-5mpdR: undetectable	5zbdA-5mpdR: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZBD_B_TRPB501_0 (FLAVIN-DEPENDENT L-TRYPTOPHAN OXIDASE VIOA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN7 (Saccharomyces cerevisiae)	5 / 10	LEU R 364 TYR R 338 ASP R 367 VAL R 359 GLY R 358	None	1.44A	5zbdB-5mpdR: undetectable	5zbdB-5mpdR: 20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_A_EY4A501_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 26S PROTEASOME REGULATORY SUBUNIT RPN5 26S PROTEASOME REGULATORY SUBUNIT RPN8 (Saccharomyces cerevisiae; Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	GLN U 230 VAL U 232 PRO O 355 THR P 428	None	1.45A	6cduA-5mpdU: undetectable 6cduB-5mpdU: undetectable	6cduA-5mpdU: 21.01 6cduB-5mpdU: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_A_ADNA503_1 (ADENOSYLHOMOCYSTEINA SE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	LEU N 253 GLN N 256 LYS N 244	None	0.96A	6exiB-5mpdN: undetectable	6exiB-5mpdN: 6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_B_ADNB503_0 (ADENOSYLHOMOCYSTEINA SE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	LEU N 253 GLN N 256 LYS N 244	None	0.99A	6exiA-5mpdN: undetectable	6exiA-5mpdN: 6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_B_ADNB503_0 (ADENOSYLHOMOCYSTEINA SE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN9 (Saccharomyces cerevisiae)	3 / 3	LEU O 336 GLN O 354 LYS O 290	None	0.88A	6exiA-5mpdO: undetectable	6exiA-5mpdO: 12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H1L_A_FJQA501_0 (BIFUNCTIONAL CYTOCHROME P450/NADPH--P450 REDUCTASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN3 (Saccharomyces cerevisiae)	5 / 10	ALA S 195 LEU S 194 VAL S 156 ILE S 187 LEU S 210	None	1.37A	6h1lA-5mpdS: undetectable	6h1lA-5mpdS: 23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7L_A_Y00A406_1 (BETA-1 ADRENERGIC RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	GLY N 693 VAL N 701 PHE N 739 PHE N 736	None	0.87A	6h7lA-5mpdN: undetectable	6h7lA-5mpdN: 6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6H7L_B_Y00B405_1 (BETA-1 ADRENERGIC RECEPTOR)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	GLY N 693 VAL N 701 PHE N 739 PHE N 736	None	0.88A	6h7lB-5mpdN: undetectable	6h7lB-5mpdN: 6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6JNH_A_ASCA202_0 (PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	ASN N 900 PRO N 876 GLN N 878	None	0.92A	6jnhA-5mpdN: undetectable	6jnhA-5mpdN: 10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6JOG_A_ASCA202_0 (PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	3 / 3	ASN N 900 PRO N 876 GLN N 878	None	0.89A	6jogA-5mpdN: undetectable	6jogA-5mpdN: 10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_D_AM2D301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 8	TRP N 362 HIS N 444 ARG N 515 GLU N 479	None	1.12A	6mn4D-5mpdN: undetectable	6mn4D-5mpdN: 13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN4_F_AM2F301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 7	TRP N 362 HIS N 444 ARG N 515 GLU N 479	None	1.24A	6mn4F-5mpdN: undetectable	6mn4F-5mpdN: 13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_A_LLLA301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	ASP N 500 TYR N 471 GLU N 468 GLU N 461	None	1.40A	6mn5A-5mpdN: undetectable	6mn5A-5mpdN: 6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MN5_C_LLLC301_0 (AMINOGLYCOSIDE N(3)-ACETYLTRANSFERA SE, AAC(3)-IVA)	5mpd	26S PROTEASOME REGULATORY SUBUNIT RPN2 (Saccharomyces cerevisiae)	4 / 6	ASP N 500 TYR N 471 GLU N 468 GLU N 461	None	1.41A	6mn5C-5mpdN: undetectable	6mn5C-5mpdN: 6.04