SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2J9D_A_ACTA1117_0 (HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059)	5mpg	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	3 / 3	ASP A 48 ARG A 47 ARG A 55	None G B 5 ( 4.0A) G B 4 ( 3.6A)	0.87A	2j9dA-5mpgA: 2.9 2j9dC-5mpgA: 2.5	2j9dA-5mpgA: 25.20 2j9dC-5mpgA: 25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNI_A_SALA1344_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5mpg	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	5 / 7	ARG A 14 THR A 61 VAL A 60 LEU A 40 ALA A 63	None	1.28A	3uniA-5mpgA: undetectable	3uniA-5mpgA: 5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZPH_A_PRLA501_0 (ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1)	5mpg	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	4 / 7	ARG A 82 VAL A 84 LEU A 21 SER A 22	U B 1 ( 3.0A) None None None	0.94A	4zphA-5mpgA: undetectable 4zphB-5mpgA: undetectable	4zphA-5mpgA: 15.49 4zphB-5mpgA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_K_IPHK101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	5mpg	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	4 / 6	VAL A 84 HIS A 77 HIS A 33 LEU A 30	None	0.87A	5hrqH-5mpgA: undetectable 5hrqK-5mpgA: undetectable 5hrqL-5mpgA: undetectable	5hrqH-5mpgA: 15.91 5hrqK-5mpgA: 8.25 5hrqL-5mpgA: 15.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2J9D_A_ACTA1117_0","HYPOTHETICAL NITROGEN REGULATORY PII-LIKE PROTEIN MJ0059","5mpg","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",3,"ASP A  48;ARG A  47;ARG A  55","None;  G B   5 ( 4.0A);  G B   4 ( 3.6A)","0.87A","2j9dA-5mpgA:2.9;2j9dC-5mpgA:2.5","2j9dA-5mpgA:25.20;2j9dC-5mpgA:25.20"],["3UNI_A_SALA1344_1","XANTHINE DEHYDROGENASE\/OXIDASE","5mpg","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",5,"ARG A  14;THR A  61;VAL A  60;LEU A  40;ALA A  63","None","1.28A","3uniA-5mpgA:undetectable","3uniA-5mpgA:5.79"],["4ZPH_A_PRLA501_0","ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR;ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1","5mpg","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",4,"ARG A  82;VAL A  84;LEU A  21;SER A  22","  U B   1 ( 3.0A);None;None;None","0.94A","4zphA-5mpgA:undetectable;4zphB-5mpgA:undetectable","4zphA-5mpgA:15.49;4zphB-5mpgA:16.34"],["5HRQ_K_IPHK101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","5mpg","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",4,"VAL A  84;HIS A  77;HIS A  33;LEU A  30","None","0.87A","5hrqH-5mpgA:undetectable;5hrqK-5mpgA:undetectable;5hrqL-5mpgA:undetectable","5hrqH-5mpgA:15.91;5hrqK-5mpgA:8.25;5hrqL-5mpgA:15.91"]]