SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5mpl	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	4 / 8	THR A 169 GLY A 111 GLY A 110 VAL A 109	None C B 2 ( 2.7A) C B 2 ( 2.9A) None	0.82A	4qvvK-5mplA: undetectable 4qvvL-5mplA: undetectable	4qvvK-5mplA: 19.34 4qvvL-5mplA: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVV_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	5mpl	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	4 / 8	THR A 169 GLY A 111 GLY A 110 VAL A 109	None C B 2 ( 2.7A) C B 2 ( 2.9A) None	0.81A	4qvvY-5mplA: undetectable 4qvvZ-5mplA: undetectable	4qvvY-5mplA: 19.34 4qvvZ-5mplA: 16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWU_A_ACAA18_1 (WTFP-TAG,GP41)	5mpl	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1 (Homo sapiens)	5 / 12	GLY A 111 LYS A 113 GLU A 117 LEU A 121 GLU A 118	C B 2 ( 2.7A) None None None None	1.22A	5nwuA-5mplA: undetectable	5nwuA-5mplA: 17.53

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4QVV_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5mpl","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",4,"THR A 169;GLY A 111;GLY A 110;VAL A 109","None;  C B   2 ( 2.7A);  C B   2 ( 2.9A);None","0.82A","4qvvK-5mplA:undetectable;4qvvL-5mplA:undetectable","4qvvK-5mplA:19.34;4qvvL-5mplA:16.43"],["4QVV_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","5mpl","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",4,"THR A 169;GLY A 111;GLY A 110;VAL A 109","None;  C B   2 ( 2.7A);  C B   2 ( 2.9A);None","0.81A","4qvvY-5mplA:undetectable;4qvvZ-5mplA:undetectable","4qvvY-5mplA:19.34;4qvvZ-5mplA:16.43"],["5NWU_A_ACAA18_1","WTFP-TAG,GP41","5mpl","HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1","Homo sapiens",5,"GLY A 111;LYS A 113;GLU A 117;LEU A 121;GLU A 118","  C B   2 ( 2.7A);None;None;None;None","1.22A","5nwuA-5mplA:undetectable","5nwuA-5mplA:17.53"]]