SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens) 		3 / 3 TRP A  38
THR A  19
TYR A  11
 None
 1.27A 2a3aA-5mpoA:
undetectable		 2a3aA-5mpoA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens) 		3 / 3 TRP A  38
THR A  19
TYR A  11
 None
 1.29A 2a3bA-5mpoA:
undetectable		 2a3bA-5mpoA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens) 		4 / 7 PHE A  57
LEU A  37
LEU A  73
LEU A  71
 None
 0.88A 3bgdB-5mpoA:
undetectable		 3bgdB-5mpoA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mpo MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 12 GLY C  76
ILE C 137
ILE C 136
SER C 134
HIS C 123
 None
 1.16A 4iv0B-5mpoC:
undetectable		 4iv0B-5mpoC:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens) 		5 / 11 THR A  43
LEU A  48
TYR A  11
VAL A   9
ILE A  26
 None
 1.41A 4lhmA-5mpoA:
undetectable		 4lhmA-5mpoA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 5mpo MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		5 / 9 ALA C 120
ILE C 110
ILE C 155
ILE C  71
VAL C  63
 None
 0.96A 4nptA-5mpoC:
undetectable		 4nptA-5mpoC:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 5mpo MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT
(Homo
sapiens) 		4 / 4 THR C  50
LEU C 125
HIS C 123
GLY C 126
 None
 0.98A 5gwyA-5mpoC:
undetectable		 5gwyA-5mpoC:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT
(Homo
sapiens) 		5 / 12 ILE A  82
THR A  19
GLU A  24
SER A  23
GLU A  78
 None
 1.36A 6bzoC-5mpoA:
undetectable		 6bzoC-5mpoA:
6.35