SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		5 / 12 PHE A 321
LEU A 325
ALA A 546
ALA A 549
THR A 524
 None
 1.04A 1cbsA-5mpqA:
undetectable		 1cbsA-5mpqA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		5 / 12 PHE A 321
LEU A 325
ALA A 546
ALA A 549
THR A 524
 None
 0.97A 2fr3A-5mpqA:
undetectable		 2fr3A-5mpqA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		3 / 3 GLY A 505
TRP A 507
VAL A 443
 None
 0.76A 3n62B-5mpqA:
undetectable		 3n62B-5mpqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		3 / 3 GLY A 505
TRP A 507
VAL A 443
 None
 0.74A 3n65B-5mpqA:
undetectable		 3n65B-5mpqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		3 / 3 GLY A 505
TRP A 507
VAL A 443
 None
 0.76A 3n66B-5mpqA:
undetectable		 3n66B-5mpqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 8 TYR A 527
TYR A 508
ARG A 515
LEU A 516
 BLG  A 601 (-3.6A)
BLG  A 601 (-4.2A)
None
None
 1.12A 3wipG-5mpqA:
undetectable
3wipH-5mpqA:
undetectable		 3wipG-5mpqA:
15.85
3wipH-5mpqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 8 ARG A 515
LEU A 516
TYR A 527
TYR A 508
 None
None
BLG  A 601 (-3.6A)
BLG  A 601 (-4.2A)
 1.10A 3wipF-5mpqA:
undetectable
3wipJ-5mpqA:
undetectable		 3wipF-5mpqA:
15.85
3wipJ-5mpqA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 6 GLY A 526
LEU A 516
ASN A 519
GLU A 520
 None
 0.99A 3zqtA-5mpqA:
undetectable		 3zqtA-5mpqA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 7 ALA A 398
THR A 401
ALA A 402
THR A 387
 None
 0.97A 4qw0K-5mpqA:
undetectable		 4qw0K-5mpqA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 7 ALA A 398
THR A 401
ALA A 402
THR A 387
 None
 0.97A 4qw0Y-5mpqA:
undetectable		 4qw0Y-5mpqA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 7 PHE A 390
SER A 414
ARG A 384
TRP A 383
 None
 1.06A 4xk8A-5mpqA:
undetectable		 4xk8A-5mpqA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_K_BO2K305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		5 / 11 ALA A 448
ALA A 569
GLY A 576
ALA A 577
TYR A 428
 None
 0.96A 5lf3K-5mpqA:
undetectable
5lf3L-5mpqA:
undetectable		 5lf3K-5mpqA:
18.09
5lf3L-5mpqA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_Y_BO2Y305_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-1)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		5 / 11 ALA A 448
ALA A 569
GLY A 576
ALA A 577
TYR A 428
 None
 0.95A 5lf3Y-5mpqA:
undetectable
5lf3Z-5mpqA:
undetectable		 5lf3Y-5mpqA:
18.09
5lf3Z-5mpqA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		5 / 12 ALA A 170
THR A 133
ARG A 155
GLY A 156
LEU A 157
 None
 1.26A 5m54E-5mpqA:
2.0		 5m54E-5mpqA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 4 ASN A  51
SER A  42
ALA A  46
VAL A  47
 None
 1.34A 5nm5A-5mpqA:
undetectable		 5nm5A-5mpqA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 4 GLN A 517
GLN A 538
PRO A 542
ALA A 539
 None
 1.12A 5odcA-5mpqA:
undetectable
5odcG-5mpqA:
undetectable		 5odcA-5mpqA:
22.55
5odcG-5mpqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 5 PRO A 542
ALA A 539
GLN A 517
GLN A 538
 None
 1.11A 5odcA-5mpqA:
undetectable
5odcG-5mpqA:
undetectable		 5odcA-5mpqA:
22.55
5odcG-5mpqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 7 THR A 506
HIS A 439
MET A 490
MET A 474
 None
 1.28A 5u6mA-5mpqA:
undetectable		 5u6mA-5mpqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		4 / 7 THR A 506
HIS A 439
MET A 490
MET A 474
 None
 1.40A 5u6mB-5mpqA:
undetectable		 5u6mB-5mpqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5mpq TRANSGLYCOSYLASE
(Neisseria
meningitidis) 		3 / 3 GLY A 505
TRP A 507
VAL A 443
 None
 0.74A 5vuoB-5mpqA:
undetectable		 5vuoB-5mpqA:
20.07