SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 8 ILE o 398
VAL o 344
TYR o 350
CYH o 352
 None
None
C  I  59 ( 4.7A)
None
 1.25A 2xz5A-5mpso:
undetectable
2xz5C-5mpso:
undetectable		 2xz5A-5mpso:
17.76
2xz5C-5mpso:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 8 ILE o 398
VAL o 344
TYR o 350
CYH o 352
 None
None
C  I  59 ( 4.7A)
None
 1.25A 2xz5C-5mpso:
undetectable
2xz5D-5mpso:
undetectable		 2xz5C-5mpso:
17.76
2xz5D-5mpso:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 6 HIS o 345
ASN o 349
ASN o 343
TRP o 412
 None
U  I  60 ( 3.5A)
None
None
 1.49A 3galA-5mpso:
undetectable		 3galA-5mpso:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_B_1GNB999_1
(GALECTIN-7)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 6 HIS o 345
ASN o 349
ASN o 343
TRP o 412
 None
U  I  60 ( 3.5A)
None
None
 1.42A 3galB-5mpso:
undetectable		 3galB-5mpso:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		3 / 3 PHE o 302
TYR o 350
LEU o 299
 None
C  I  59 ( 4.7A)
None
 0.63A 3keeB-5mpso:
undetectable		 3keeB-5mpso:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Saccharomyces
cerevisiae) 		5 / 12 GLY h  89
VAL h  25
ILE h  39
VAL h  15
ILE h  17
 U  5 172 ( 3.8A)
None
None
None
None
 1.03A 3nduC-5mpsh:
undetectable		 3nduC-5mpsh:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		3 / 3 PHE o 302
TYR o 350
LEU o 299
 None
C  I  59 ( 4.7A)
None
 0.65A 3sueB-5mpso:
undetectable		 3sueB-5mpso:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5mps PRE-MRNA-SPLICING
FACTOR SYF2
(Saccharomyces
cerevisiae) 		3 / 3 TYR y  97
LEU y 109
LYS y 107
 A  6  91 ( 3.3A)
None
A  6  94 ( 3.3A)
 0.69A 3sueD-5mpsy:
undetectable		 3sueD-5mpsy:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 5mps PRE-MRNA-SPLICING
FACTOR 18
(Saccharomyces
cerevisiae) 		3 / 3 LEU a 143
LYS a 140
THR a 139
 None
 0.61A 4lj0A-5mpsa:
undetectable		 4lj0A-5mpsa:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA304_1
(TYROSINASE)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 5 LEU o 177
HIS o 176
GLU o 236
THR o 235
 None
 1.19A 4p6sA-5mpso:
undetectable		 4p6sA-5mpso:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		5 / 12 GLY o 181
GLY o 182
THR o 165
LYS o 210
TRP o 233
 None
 0.78A 4pghD-5mpso:
undetectable		 4pghD-5mpso:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWZ_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Saccharomyces
cerevisiae) 		3 / 3 MET h  36
GLN h  35
ARG h  88
 U  5 173 ( 4.6A)
U  5 172 ( 3.8A)
U  5 171 ( 2.9A)
 1.09A 5ewzB-5mpsh:
undetectable		 5ewzB-5mpsh:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 8 ARG o 200
PRO o 162
GLY o 182
ASP o 184
 None
 1.16A 5kf8A-5mpso:
undetectable		 5kf8A-5mpso:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 8 ARG o 200
PRO o 162
GLY o 182
ASP o 184
 None
 1.07A 5kgpA-5mpso:
undetectable		 5kgpA-5mpso:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5mps PRE-MRNA-PROCESSING
FACTOR 17
(Saccharomyces
cerevisiae) 		4 / 8 ARG o 200
PRO o 162
GLY o 182
ASP o 184
 None
 1.05A 5kgpB-5mpso:
undetectable		 5kgpB-5mpso:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Saccharomyces
cerevisiae) 		3 / 3 MET h  36
GLN h  35
ARG h  88
 U  5 173 ( 4.6A)
U  5 172 ( 3.8A)
U  5 171 ( 2.9A)
 1.13A 5m35B-5mpsh:
undetectable		 5m35B-5mpsh:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Saccharomyces
cerevisiae) 		3 / 3 MET h  36
GLN h  35
ARG h  88
 U  5 173 ( 4.6A)
U  5 172 ( 3.8A)
U  5 171 ( 2.9A)
 1.12A 5m36A-5mpsh:
undetectable		 5m36A-5mpsh:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Saccharomyces
cerevisiae) 		3 / 3 MET h  36
GLN h  35
ARG h  88
 U  5 173 ( 4.6A)
U  5 172 ( 3.8A)
U  5 171 ( 2.9A)
 1.13A 6fn9A-5mpsh:
undetectable		 6fn9A-5mpsh:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5mps SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D1
(Saccharomyces
cerevisiae) 		3 / 3 MET h  36
GLN h  35
ARG h  88
 U  5 173 ( 4.6A)
U  5 172 ( 3.8A)
U  5 171 ( 2.9A)
 1.12A 6fnbA-5mpsh:
undetectable		 6fnbA-5mpsh:
19.82