SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLU A1990
GLY A1992
GLY A1994
LEU A2024
ILE A2045
 None
SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
None
SAH  A2201 (-3.8A)
 0.73A 1qaoA-5mptA:
9.8		 1qaoA-5mptA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 ILE A1931
ALA A1928
LEU A1874
ILE A1845
PHE A2103
 None
 1.40A 1y0xX-5mptA:
undetectable		 1y0xX-5mptA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 ALA A2068
LEU A2108
PHE A2105
THR A1995
LEU A1919
 SAH  A2201 ( 3.9A)
None
None
SAH  A2201 (-3.0A)
None
 1.20A 2oipC-5mptA:
undetectable		 2oipC-5mptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1994
GLY A1997
LEU A2020
ILE A2045
 SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
SAH  A2201 (-3.5A)
SAH  A2201 (-3.7A)
SAH  A2201 (-3.8A)
 0.99A 2oxtC-5mptA:
6.8		 2oxtC-5mptA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 5 LEU A1874
LEU A1879
ILE A1845
ARG A1846
 None
 0.71A 2qd4A-5mptA:
2.2		 2qd4A-5mptA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 7 THR A1827
VAL A1831
GLU A1876
PRO A2099
 None
 1.07A 2v2gA-5mptA:
undetectable
2v2gB-5mptA:
undetectable		 2v2gA-5mptA:
22.41
2v2gB-5mptA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 7 PRO A2099
THR A1827
VAL A1831
GLU A1876
 None
 1.06A 2v41E-5mptA:
undetectable
2v41F-5mptA:
2.0		 2v41E-5mptA:
22.41
2v41F-5mptA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 8 ILE A1988
PHE A2088
LEU A1979
LEU A1790
 None
 0.85A 2w98B-5mptA:
6.0		 2w98B-5mptA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 8 GLN A1840
PHE A1927
GLY A1933
MET A1867
 None
 0.91A 2y6rB-5mptA:
2.3		 2y6rB-5mptA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DFR_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 LEU A2091
ALA A2158
LEU A2083
PRO A2049
ALA A2062
 None
 1.11A 3dfrA-5mptA:
undetectable		 3dfrA-5mptA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1996
GLY A1997
LEU A2020
ILE A2045
 SAH  A2201 (-3.2A)
SAH  A2201 ( 4.3A)
SAH  A2201 (-3.5A)
SAH  A2201 (-3.7A)
SAH  A2201 (-3.8A)
 0.91A 3douA-5mptA:
9.8		 3douA-5mptA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 11 LEU A2089
ALA A2062
LEU A2061
MET A2002
ALA A1968
 None
 1.18A 3e22B-5mptA:
undetectable		 3e22B-5mptA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 11 LEU A2089
ALA A2062
LEU A2061
MET A2002
ALA A1968
 None
 1.17A 3e22D-5mptA:
3.1		 3e22D-5mptA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1994
GLY A1997
LEU A2020
ASN A2044
 SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
SAH  A2201 (-3.5A)
SAH  A2201 (-3.7A)
SAH  A2201 (-2.8A)
 0.68A 3eluA-5mptA:
6.1		 3eluA-5mptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1994
GLY A1997
LEU A2020
ASN A2044
 SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
SAH  A2201 (-3.5A)
SAH  A2201 (-3.7A)
SAH  A2201 (-2.8A)
 0.63A 3embA-5mptA:
6.7		 3embA-5mptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 ALA A2068
LEU A2108
PHE A2105
THR A1995
LEU A1919
 SAH  A2201 ( 3.9A)
None
None
SAH  A2201 (-3.0A)
None
 1.18A 3hj3A-5mptA:
2.1		 3hj3A-5mptA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 ALA A2068
LEU A2108
PHE A2105
THR A1995
LEU A1919
 SAH  A2201 ( 3.9A)
None
None
SAH  A2201 (-3.0A)
None
 1.17A 3hj3C-5mptA:
undetectable		 3hj3C-5mptA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1994
GLY A1996
THR A1998
ILE A2045
 SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
SAH  A2201 ( 4.3A)
None
SAH  A2201 (-3.8A)
 0.76A 3ihtA-5mptA:
9.6		 3ihtA-5mptA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 6 PHE A1838
PHE A1927
ALA A1928
THR A1932
 None
 1.05A 3t3sB-5mptA:
undetectable		 3t3sB-5mptA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 6 GLY A2110
ARG A1865
GLU A2115
ARG A2070
 None
 1.22A 4bqfA-5mptA:
undetectable		 4bqfA-5mptA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 5 LEU A2155
LEU A2090
MET A2002
THR A2063
 None
None
None
SAH  A2201 (-3.7A)
 1.45A 4do3A-5mptA:
undetectable		 4do3A-5mptA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 5 LEU A1874
LEU A1879
ILE A1845
ARG A1846
 None
 0.74A 4klrA-5mptA:
undetectable		 4klrA-5mptA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1994
LEU A2020
SER A2021
CYH A2065
 SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
SAH  A2201 (-3.7A)
None
SAH  A2201 (-4.8A)
 1.09A 4krhB-5mptA:
14.7		 4krhB-5mptA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
GLY A1994
ASP A2019
LEU A2020
GLU A2046
 SAH  A2201 (-3.2A)
SAH  A2201 (-3.0A)
SAH  A2201 (-2.0A)
SAH  A2201 (-3.7A)
SAH  A2201 ( 4.5A)
 1.02A 4lg1A-5mptA:
12.1		 4lg1A-5mptA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_1
(ADENOSINE KINASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1997
GLY A1996
PHE A2032
MET A2017
ALA A2027
 SAH  A2201 (-3.5A)
SAH  A2201 ( 4.3A)
None
None
None
 1.28A 4ubeA-5mptA:
undetectable		 4ubeA-5mptA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 6 ARG A1889
CYH A1843
GLN A1852
ILE A1880
 None
 1.21A 4w5tA-5mptA:
undetectable		 4w5tA-5mptA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 5 ASP A2019
TYR A2015
LEU A1989
THR A1999
 SAH  A2201 (-2.0A)
None
None
None
 1.24A 4wozF-5mptA:
undetectable
4wozH-5mptA:
undetectable		 4wozF-5mptA:
21.78
4wozH-5mptA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLU A1990
GLY A1992
LEU A2020
SER A2021
ILE A2045
 None
SAH  A2201 (-3.2A)
SAH  A2201 (-3.7A)
None
SAH  A2201 (-3.8A)
 0.46A 5dpdA-5mptA:
13.5		 5dpdA-5mptA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1992
ASP A2019
LEU A2020
SER A2021
ILE A2045
 SAH  A2201 (-3.2A)
SAH  A2201 (-2.0A)
SAH  A2201 (-3.7A)
None
SAH  A2201 (-3.8A)
 0.56A 5dpdB-5mptA:
13.6		 5dpdB-5mptA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		3 / 3 GLY A1994
ASP A2019
ASN A2044
 SAH  A2201 (-3.0A)
SAH  A2201 (-2.0A)
SAH  A2201 (-2.8A)
 0.35A 5jglA-5mptA:
19.0		 5jglA-5mptA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 12 GLY A1924
SER A1925
GLU A1905
LEU A1903
GLU A1904
 None
 1.17A 5nwuA-5mptA:
undetectable		 5nwuA-5mptA:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		5 / 9 LEU A2009
LEU A2005
ILE A2059
LEU A1979
ALA A1968
 None
 1.30A 5og9A-5mptA:
undetectable		 5og9A-5mptA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5mpt CITRININ POLYKETIDE
SYNTHASE
(Monascus
purpureus) 		4 / 6 ILE A1882
GLY A1872
TYR A1871
GLU A1875
 None
 1.08A 6gqiA-5mptA:
undetectable		 6gqiA-5mptA:
22.74