SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 9 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.03A 1eqgA-5mq6A:
undetectable		 1eqgA-5mq6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 11 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.04A 1eqgB-5mq6A:
undetectable		 1eqgB-5mq6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 THR A 301
GLY A 304
LYS A 425
TYR A 420
 NDP  A 701 (-3.5A)
GOL  A 702 ( 4.0A)
NDP  A 701 (-2.7A)
GOL  A 702 (-4.9A)
 1.33A 1gtiC-5mq6A:
undetectable		 1gtiC-5mq6A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 ALA A 607
TYR A 600
GLY A 599
ILE A 601
LEU A 532
 None
NDP  A 701 (-4.4A)
None
None
None
 1.14A 1kglA-5mq6A:
undetectable		 1kglA-5mq6A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 VAL A 112
ILE A 552
ILE A 109
LEU A  97
VAL A 553
 None
 1.03A 1oipA-5mq6A:
undetectable		 1oipA-5mq6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ASP A 446
LYS A 450
ARG A  35
 None
 1.06A 1ra8A-5mq6A:
undetectable		 1ra8A-5mq6A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 THR A 492
LEU A 221
VAL A 219
VAL A 199
 None
 1.06A 1t85A-5mq6A:
undetectable		 1t85A-5mq6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.70A 1tt6B-5mq6A:
undetectable		 1tt6B-5mq6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.65A 1tz8C-5mq6A:
undetectable
1tz8D-5mq6A:
undetectable		 1tz8C-5mq6A:
12.82
1tz8D-5mq6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 LYS A  46
ASP A 495
ASP A 506
 None
 0.98A 2br4A-5mq6A:
undetectable		 2br4A-5mq6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 9 ALA A  94
TYR A  93
ALA A 222
GLY A  85
GLY A  89
 None
None
FAD  A 700 (-4.8A)
FAD  A 700 (-3.6A)
FAD  A 700 (-3.4A)
 1.31A 2v7bA-5mq6A:
undetectable		 2v7bA-5mq6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 9 ALA A  94
TYR A  93
ALA A 222
GLY A  85
GLY A  89
 None
None
FAD  A 700 (-4.8A)
FAD  A 700 (-3.6A)
FAD  A 700 (-3.4A)
 1.30A 2v7bB-5mq6A:
undetectable		 2v7bB-5mq6A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 THR A 492
LEU A 221
VAL A 219
VAL A 199
 None
 1.08A 2zuhA-5mq6A:
undetectable		 2zuhA-5mq6A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 PRO A 376
PHE A 581
LYS A 585
 None
 1.24A 3bjwG-5mq6A:
1.6		 3bjwG-5mq6A:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 ALA A 222
THR A 549
ILE A 552
THR A 530
 FAD  A 700 (-4.8A)
None
None
None
 0.82A 3bpxA-5mq6A:
undetectable
3bpxB-5mq6A:
undetectable		 3bpxA-5mq6A:
12.83
3bpxB-5mq6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 LEU A  39
GLY A 605
GLY A  38
ALA A 607
THR A 602
 None
 1.14A 3dh0A-5mq6A:
3.4		 3dh0A-5mq6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 LEU A  39
GLY A 605
GLY A  38
ALA A 607
THR A 602
 None
 1.14A 3dh0B-5mq6A:
undetectable		 3dh0B-5mq6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 4 PRO A 421
TYR A  26
GLY A 595
THR A 594
 None
 1.28A 3ib0A-5mq6A:
undetectable		 3ib0A-5mq6A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		6 / 12 ILE A 483
GLY A 484
GLY A 485
ALA A 513
ALA A 489
VAL A 490
 None
 1.06A 3jb2A-5mq6A:
undetectable		 3jb2A-5mq6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.07A 3n8zA-5mq6A:
undetectable		 3n8zA-5mq6A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A  85
GLY A  90
ALA A 115
ALA A 114
LEU A 221
 FAD  A 700 (-3.6A)
None
FAD  A 700 ( 4.0A)
FAD  A 700 (-3.6A)
None
 1.01A 3p2kC-5mq6A:
2.8		 3p2kC-5mq6A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A  85
GLY A  90
ALA A 115
ALA A 114
LEU A 221
 FAD  A 700 (-3.6A)
None
FAD  A 700 ( 4.0A)
FAD  A 700 (-3.6A)
None
 0.97A 3p2kD-5mq6A:
2.1		 3p2kD-5mq6A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.06A 3rr3A-5mq6A:
1.0		 3rr3A-5mq6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 VAL A 199
VAL A  73
LEU A 178
SER A  77
LEU A 214
 None
 1.07A 3rr3B-5mq6A:
undetectable		 3rr3B-5mq6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 ILE A 552
TYR A 640
GLY A 518
PRO A 531
 None
 0.80A 3uboB-5mq6A:
undetectable		 3uboB-5mq6A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_A_H4BA600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 SER A 430
ILE A 282
PHE A 437
GLU A 432
 None
 1.25A 4cx7A-5mq6A:
undetectable
4cx7B-5mq6A:
undetectable		 4cx7A-5mq6A:
20.85
4cx7B-5mq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 SER A 430
ILE A 282
PHE A 437
GLU A 432
 None
 1.12A 4cx7C-5mq6A:
undetectable
4cx7D-5mq6A:
undetectable		 4cx7C-5mq6A:
20.85
4cx7D-5mq6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.64A 4d7bB-5mq6A:
undetectable		 4d7bB-5mq6A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 8 PHE A 649
VAL A 555
HIS A 517
TYR A 640
 None
 1.18A 4f5zA-5mq6A:
undetectable		 4f5zA-5mq6A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 GLU A  37
GLN A  41
THR A 301
ARG A 300
 None
None
NDP  A 701 (-3.5A)
NDP  A 701 (-3.9A)
 1.26A 4lnxA-5mq6A:
undetectable		 4lnxA-5mq6A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 PHE A 362
MET A 359
ARG A 426
VAL A 134
 None
None
FAD  A 700 ( 4.2A)
FAD  A 700 (-4.4A)
 1.22A 4mk4B-5mq6A:
2.3		 4mk4B-5mq6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A  90
GLY A  87
PHE A 118
LEU A 220
ILE A  82
 None
FAD  A 700 (-3.5A)
None
None
None
 0.82A 4n48A-5mq6A:
undetectable		 4n48A-5mq6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A  90
GLY A  87
PHE A 118
LEU A 220
ILE A  82
 None
FAD  A 700 (-3.5A)
None
None
None
 0.82A 4n48B-5mq6A:
undetectable		 4n48B-5mq6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A  90
GLY A  87
PHE A 118
LEU A 220
ILE A  82
 None
FAD  A 700 (-3.5A)
None
None
None
 0.85A 4n49A-5mq6A:
undetectable		 4n49A-5mq6A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 LEU A 334
GLN A 348
VAL A 352
MET A 351
ILE A 366
 None
 1.40A 4oktA-5mq6A:
undetectable		 4oktA-5mq6A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 10 VAL A  73
VAL A 199
LEU A 214
GLY A 202
LEU A 178
 None
 1.12A 4ph9A-5mq6A:
undetectable		 4ph9A-5mq6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 10 VAL A  73
VAL A 199
LEU A 214
GLY A 202
LEU A 178
 None
 1.13A 4ph9B-5mq6A:
undetectable		 4ph9B-5mq6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.64A 4pwjB-5mq6A:
undetectable		 4pwjB-5mq6A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A 204
GLY A 206
LEU A  67
ALA A  69
ALA A  65
 None
 0.91A 4uckA-5mq6A:
undetectable		 4uckA-5mq6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 GLY A 204
GLY A 206
LEU A  67
ALA A  69
ALA A  65
 None
 0.93A 4uckB-5mq6A:
undetectable		 4uckB-5mq6A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 GLU A 577
ALA A 578
PHE A 581
 None
 0.42A 4v1fA-5mq6A:
undetectable		 4v1fA-5mq6A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 GLU A 577
ALA A 578
PHE A 581
 None
 0.44A 4v1fC-5mq6A:
undetectable		 4v1fC-5mq6A:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 ARG A 426
ASP A 133
TYR A 139
 FAD  A 700 ( 4.2A)
FAD  A 700 (-3.2A)
FAD  A 700 (-4.0A)
 0.95A 4yo9B-5mq6A:
undetectable		 4yo9B-5mq6A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 LYS A 153
TYR A 137
TYR A 148
LEU A 143
 None
 1.31A 5bmvB-5mq6A:
undetectable		 5bmvB-5mq6A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.64A 5bojB-5mq6A:
undetectable		 5bojB-5mq6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSE_C_HQEC1583_1
(UREASE SUBUNIT ALPHA)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 5 ILE A 322
GLN A 329
ARG A 332
GLU A 144
 None
 1.34A 5fseC-5mq6A:
undetectable		 5fseC-5mq6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		3 / 3 VAL A 365
SER A 363
TRP A 423
 None
 1.01A 5jwaA-5mq6A:
0.0		 5jwaA-5mq6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 6 LEU A 197
ALA A 216
LEU A 214
SER A  77
 None
 0.65A 5l4iB-5mq6A:
undetectable		 5l4iB-5mq6A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 11 THR A 594
ALA A 607
THR A 602
ALA A 591
LEU A 532
 None
 1.13A 5lf7H-5mq6A:
undetectable
5lf7I-5mq6A:
undetectable		 5lf7H-5mq6A:
17.12
5lf7I-5mq6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		5 / 12 VAL A 112
ILE A 552
ILE A 109
LEU A  97
VAL A 553
 None
 1.04A 5mugA-5mq6A:
undetectable		 5mugA-5mq6A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN
(Thermothelomyces
thermophila) 		4 / 7 GLY A 129
LEU A 130
GLY A 257
TYR A 252
 None
 0.82A 6nm4A-5mq6A:
undetectable		 6nm4A-5mq6A:
14.51