SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4001_1
(SERUM ALBUMIN)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		5 / 9 LEU A 162
ILE A 159
VAL A 132
GLY A 131
LEU A  69
 None
 0.99A 1e7aB-5mqiA:
undetectable		 1e7aB-5mqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A 345
LEU A 198
VAL A 163
VAL A 222
 None
 0.95A 1e7aB-5mqiA:
undetectable		 1e7aB-5mqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 7 TRP A 191
HIS A 194
LEU A 190
ASP A 199
 SO4  A1602 ( 4.1A)
None
None
None
 1.22A 1ismB-5mqiA:
undetectable		 1ismB-5mqiA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 8 PHE A 130
LEU A 133
ILE A 156
ILE A 159
 None
 0.87A 1sbrA-5mqiA:
undetectable		 1sbrA-5mqiA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 156
PHE A 349
ALA A 387
ALA A 383
MET A 225
 None
 1.34A 2x2nD-5mqiA:
undetectable		 2x2nD-5mqiA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		5 / 10 THR A 136
GLU A 135
LEU A 140
LEU A 141
ILE A 156
 None
 1.19A 3kvrB-5mqiA:
undetectable		 3kvrB-5mqiA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 7 ILE A 411
LEU A 415
ALA A 442
TYR A 378
 None
 0.69A 4g77A-5mqiA:
undetectable		 4g77A-5mqiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 7 LEU A 366
ARG A 406
SER A 215
MET A 358
 None
SO4  A1600 (-3.6A)
None
None
 1.19A 4klrA-5mqiA:
undetectable		 4klrA-5mqiA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 6 THR A  70
VAL A 132
VAL A  82
HIS A  72
 None
 0.98A 5eclA-5mqiA:
undetectable		 5eclA-5mqiA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		3 / 3 LYS A 441
GLN A 229
ASN A 230
 None
 1.08A 5l2tA-5mqiA:
undetectable		 5l2tA-5mqiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_A_BEZA502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A  79
LEU A  66
LEU A  69
HIS A  73
 None
 1.01A 6e43A-5mqiA:
2.8		 6e43A-5mqiA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_B_BEZB502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A  79
LEU A  66
LEU A  69
HIS A  73
 None
 1.02A 6e43B-5mqiA:
5.0		 6e43B-5mqiA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_C_BEZC502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 5mqi PROTEIN TIMELESS
HOMOLOG,PROTEIN
TIMELESS HOMOLOG
(Homo
sapiens) 		4 / 6 PHE A  79
LEU A  66
LEU A  69
HIS A  73
 None
 0.97A 6e43C-5mqiA:
3.1		 6e43C-5mqiA:
25.74