SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		4 / 7 ALA C  81
SER C  51
SER C  55
THR C  59
 None
 1.07A 1dvxA-5mr4C:
undetectable		 1dvxA-5mr4C:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		5 / 12 SER C 126
ASP C 270
ARG C 276
PRO C 286
ALA C 287
 None
 1.42A 1s14B-5mr4C:
undetectable		 1s14B-5mr4C:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_A_AZMA229_2
(CARBONIC ANHYDRASE)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		3 / 3 GLN C 291
PHE C 355
TYR C 217
 None
 0.94A 3ucjB-5mr4C:
undetectable		 3ucjB-5mr4C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		3 / 3 GLN C 291
PHE C 355
TYR C 217
 None
 0.96A 3ucjA-5mr4C:
undetectable		 3ucjA-5mr4C:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		4 / 4 PRO C  89
LEU C  90
ILE C 112
ARG C  61
 None
 1.39A 3w1wA-5mr4C:
undetectable		 3w1wA-5mr4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8Y_C_VK3C202_1
(NADPH QUINONE
OXIDOREDUCTASE)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		4 / 7 TYR C 181
LEU C 204
ASN C 308
TYR C 297
 None
 1.34A 4f8yC-5mr4C:
undetectable
4f8yD-5mr4C:
undetectable		 4f8yC-5mr4C:
16.75
4f8yD-5mr4C:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		5 / 12 ASP C 304
LEU C 220
ASN C 308
ILE C 237
ARG C 197
 None
 1.29A 4kmuC-5mr4C:
undetectable		 4kmuC-5mr4C:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		4 / 7 ILE C 317
TYR C 309
ASN C 357
ARG C 233
 None
 1.32A 4o7gA-5mr4C:
undetectable
4o7gB-5mr4C:
undetectable		 4o7gA-5mr4C:
undetectable
4o7gB-5mr4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		3 / 3 ARG C 198
HIS C 201
ARG C 205
 None
 1.14A 6dwdD-5mr4C:
undetectable		 6dwdD-5mr4C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5mr4 GDNF FAMILY RECEPTOR
ALPHA-2
(Homo
sapiens) 		4 / 5 TYR C 128
PHE C 303
MET C 300
GLY C 299
 None
 1.41A 6hd4A-5mr4C:
undetectable		 6hd4A-5mr4C:
10.98