SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mr6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 12 ALA A 310
ALA A 311
LEU A 317
ALA A 316
VAL A 242
 None
 0.99A 1fm6U-5mr6A:
undetectable		 1fm6U-5mr6A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		6 / 10 ALA A 236
ALA A 235
LEU A 317
LEU A 307
ALA A 310
VAL A  68
 None
 1.08A 2bxgB-5mr6A:
undetectable		 2bxgB-5mr6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		4 / 8 MET A 240
ALA A 241
HIS A 371
ILE A 237
 GOL  A 602 (-3.7A)
None
FAD  A 601 (-3.8A)
GOL  A 602 ( 4.2A)
 0.77A 2zm9A-5mr6A:
undetectable		 2zm9A-5mr6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		4 / 7 GLY A 250
SER A  79
ALA A 365
ILE A 293
 None
 0.78A 3a2qA-5mr6A:
undetectable		 3a2qA-5mr6A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 12 ASN A  93
GLY A  94
ASP A 328
ILE A 325
LEU A 307
 None
 0.86A 3ihtA-5mr6A:
undetectable		 3ihtA-5mr6A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		4 / 6 LEU A  97
ALA A 238
LEU A 307
THR A 234
 None
 1.09A 3rozA-5mr6A:
undetectable		 3rozA-5mr6A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		3 / 3 ARG A 324
ASP A 309
ASP A  67
 None
 0.51A 4kicB-5mr6A:
undetectable		 4kicB-5mr6A:
28.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 12 GLY A 116
ASP A 152
ALA A  53
LEU A  52
VAL A  89
 None
 1.11A 5hw4A-5mr6A:
undetectable		 5hw4A-5mr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 11 GLY A 116
ASP A 152
ALA A  53
LEU A  52
VAL A  89
 None
 1.16A 5hw4B-5mr6A:
undetectable		 5hw4B-5mr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 12 GLY A 116
ASP A 152
ALA A  53
LEU A  52
VAL A  89
 None
 1.13A 5hw4C-5mr6A:
undetectable		 5hw4C-5mr6A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 12 TYR A 144
LEU A 149
GLY A 147
SER A 141
VAL A 122
 FAD  A 601 (-4.1A)
None
None
None
FAD  A 601 (-3.8A)
 1.43A 6bxlA-5mr6A:
undetectable		 6bxlA-5mr6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5mr6 XIAF PROTEIN
(Streptomyces
sp.) 		5 / 12 LEU A  55
VAL A  89
SER A  86
THR A  85
VAL A  77
 None
 1.46A 6drxA-5mr6A:
undetectable		 6drxA-5mr6A:
23.23