SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mr7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 7 VAL A 303
VAL A 371
ARG A 408
CYH A 411
 None
 1.16A 1t46A-5mr7A:
undetectable		 1t46A-5mr7A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 9 VAL A 300
ILE A 278
PHE A 468
THR A 268
VAL A 371
 None
 1.25A 3me6C-5mr7A:
undetectable		 3me6C-5mr7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 9 VAL A 300
ILE A 278
PHE A 468
THR A 268
VAL A 371
 None
 1.26A 3me6D-5mr7A:
undetectable		 3me6D-5mr7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 7 VAL A 300
ILE A 367
ILE A 344
ALA A 365
 None
 0.90A 4lv9B-5mr7A:
undetectable		 4lv9B-5mr7A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		3 / 3 PRO A 388
LEU A 387
GLN A 313
 None
 0.65A 4pevB-5mr7A:
undetectable		 4pevB-5mr7A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		4 / 6 ILE A 393
PHE A 357
THR A 343
ARG A 297
 None
 1.07A 4xe5A-5mr7A:
undetectable		 4xe5A-5mr7A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG
(Homo
sapiens) 		5 / 12 ILE A 344
LEU A 280
GLU A 348
PHE A 357
GLY A 345
 None
 1.37A 5il1A-5mr7A:
undetectable		 5il1A-5mr7A:
undetectable