SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2CDQ_B_SAMB1500_0 (ASPARTOKINASE)	5mr8	E3 UBIQUITIN-PROTEIN LIGASE TRIM33 (Homo sapiens)	4 / 7	SER A1004 ASP A1002 SER A 979 LEU A 970	None	1.08A	2cdqB-5mr8A: undetectable	2cdqB-5mr8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PO7_A_ZONA601_1 (AMINE OXIDASE [FLAVIN-CONTAINING] B)	5mr8	E3 UBIQUITIN-PROTEIN LIGASE TRIM33 (Homo sapiens)	4 / 8	LEU A1010 TYR A1018 PHE A1024 TYR A 974	None	1.34A	3po7A-5mr8A: undetectable	3po7A-5mr8A: 9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3R24_A_SAMA302_1 (2'-O-METHYL TRANSFERASE)	5mr8	E3 UBIQUITIN-PROTEIN LIGASE TRIM33 (Homo sapiens)	3 / 3	TYR A1018 ASP A1002 ASP A1027	None	0.77A	3r24A-5mr8A: undetectable	3r24A-5mr8A: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MAF_A_XINA403_2 (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE)	5mr8	E3 UBIQUITIN-PROTEIN LIGASE TRIM33 (Homo sapiens)	4 / 5	LEU A1060 CYH A 966 LEU A 958 ASP A1022	None	1.36A	5mafA-5mr8A: undetectable	5mafA-5mr8A: 20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NWU_A_ACAA18_2 (WTFP-TAG,GP41)	5mr8	E3 UBIQUITIN-PROTEIN LIGASE TRIM33 (Homo sapiens)	3 / 3	LEU A 919 LEU A 918 TRP A 926	None	0.80A	5nwuA-5mr8A: undetectable	5nwuA-5mr8A: 15.00

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2CDQ_B_SAMB1500_0","ASPARTOKINASE","5mr8","E3 UBIQUITIN-PROTEIN LIGASE TRIM33","Homo sapiens",4,"SER A1004;ASP A1002;SER A 979;LEU A 970","None","1.08A","2cdqB-5mr8A:undetectable","2cdqB-5mr8A:undetectable"],["3PO7_A_ZONA601_1","AMINE OXIDASE [FLAVIN-CONTAINING] B","5mr8","E3 UBIQUITIN-PROTEIN LIGASE TRIM33","Homo sapiens",4,"LEU A1010;TYR A1018;PHE A1024;TYR A 974","None","1.34A","3po7A-5mr8A:undetectable","3po7A-5mr8A:9.56"],["3R24_A_SAMA302_1","2'-O-METHYL TRANSFERASE","5mr8","E3 UBIQUITIN-PROTEIN LIGASE TRIM33","Homo sapiens",3,"TYR A1018;ASP A1002;ASP A1027","None","0.77A","3r24A-5mr8A:undetectable","3r24A-5mr8A:undetectable"],["5MAF_A_XINA403_2","MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE","5mr8","E3 UBIQUITIN-PROTEIN LIGASE TRIM33","Homo sapiens",4,"LEU A1060;CYH A 966;LEU A 958;ASP A1022","None","1.36A","5mafA-5mr8A:undetectable","5mafA-5mr8A:20.48"],["5NWU_A_ACAA18_2","WTFP-TAG,GP41","5mr8","E3 UBIQUITIN-PROTEIN LIGASE TRIM33","Homo sapiens",3,"LEU A 919;LEU A 918;TRP A 926","None","0.80A","5nwuA-5mr8A:undetectable","5nwuA-5mr8A:15.00"]]