SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5mra SORCIN
(Homo
sapiens) 		5 / 11 LEU A 129
LYS A 127
VAL A 120
TYR A 148
PHE A 109
 None
 1.08A 1klmA-5mraA:
undetectable		 1klmA-5mraA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5mra SORCIN
(Homo
sapiens) 		5 / 12 PHE A  70
SER A  61
LEU A  35
ILE A  49
MET A  90
 None
 1.27A 2xkwA-5mraA:
undetectable		 2xkwA-5mraA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 5mra SORCIN
(Homo
sapiens) 		3 / 3 PRO A 122
SER A 149
ASN A 142
 None
 0.92A 3lslG-5mraA:
undetectable		 3lslG-5mraA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 5mra SORCIN
(Homo
sapiens) 		3 / 3 MET A  90
GLU A  94
LEU A  98
 None
MG  A 202 (-3.9A)
None
 0.78A 4v2oB-5mraA:
undetectable		 4v2oB-5mraA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5mra SORCIN
(Homo
sapiens) 		3 / 3 ARG A 167
ARG A  84
ARG A 174
 None
 0.95A 5vcgA-5mraA:
undetectable		 5vcgA-5mraA:
16.77