SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mrt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_2
(HIV-1 PROTEASE)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		6 / 11 LEU A 200
ALA A  69
VAL A  71
GLY A 150
PRO A  26
VAL A  27
 None
 1.45A 1hxwB-5mrtA:
undetectable		 1hxwB-5mrtA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		5 / 12 TYR A  86
ALA A 160
GLY A 150
GLY A  24
ILE A 191
 None
 1.11A 1x1aA-5mrtA:
undetectable		 1x1aA-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		5 / 11 TYR A   9
PHE A  35
GLY A  56
PHE A  58
PRO A  12
 None
None
FMT  A 303 ( 4.4A)
None
None
 1.29A 2y7kA-5mrtA:
undetectable		 2y7kA-5mrtA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		3 / 3 GLY A 151
GLY A   5
GLY A  24
 None
 0.41A 3bogC-5mrtA:
undetectable		 3bogC-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ILE A   7
GLY A  24
VAL A  48
LEU A  79
 None
 0.92A 3elzA-5mrtA:
undetectable		 3elzA-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		5 / 12 TYR A  86
GLY A 151
GLY A   6
GLU A   8
ALA A  38
 None
 1.03A 3vywA-5mrtA:
undetectable		 3vywA-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		5 / 10 ASP A  67
ALA A  38
GLY A  39
VAL A 134
VAL A 194
 None
 1.42A 4c5lC-5mrtA:
undetectable		 4c5lC-5mrtA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		6 / 12 ILE A   7
GLY A  24
GLY A   6
ILE A 154
ILE A 191
LEU A 202
 None
 1.33A 4iv0A-5mrtA:
undetectable		 4iv0A-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		6 / 12 ILE A   7
GLY A  24
GLY A   6
ILE A 154
ILE A 191
LEU A 202
 None
 1.31A 4mwzA-5mrtA:
undetectable		 4mwzA-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		6 / 12 ILE A   7
GLY A  24
GLY A   6
ILE A 154
ILE A 191
LEU A 202
 None
 1.33A 4mwzB-5mrtA:
undetectable		 4mwzB-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.48A 4v2yA-5mrtA:
undetectable		 4v2yA-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 8 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.49A 4v2zB-5mrtA:
undetectable		 4v2zB-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 8 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.41A 4v30B-5mrtA:
undetectable		 4v30B-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 6 PRO A  26
ILE A   7
VAL A  48
ARG A 107
 None
 0.94A 4xe5A-5mrtA:
undetectable		 4xe5A-5mrtA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.37A 5amhA-5mrtA:
undetectable		 5amhA-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.49A 5amjA-5mrtA:
undetectable		 5amjA-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.46A 5amjB-5mrtA:
undetectable		 5amjB-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.49A 5amkB-5mrtA:
undetectable		 5amkB-5mrtA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		5 / 12 ALA A  36
GLY A 150
LEU A 163
GLY A  56
VAL A  48
 None
None
None
FMT  A 303 ( 4.4A)
None
 1.22A 5i71A-5mrtA:
undetectable		 5i71A-5mrtA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		5 / 12 ALA A  36
GLY A 150
LEU A 163
GLY A  56
VAL A  48
 None
None
None
FMT  A 303 ( 4.4A)
None
 1.25A 5i75A-5mrtA:
undetectable		 5i75A-5mrtA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.48A 5oh1A-5mrtA:
undetectable		 5oh1A-5mrtA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 8 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.13A 5oh1C-5mrtA:
undetectable		 5oh1C-5mrtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH3_A_9V2A202_0
(CEREBLON ISOFORM 4)		 5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME
(Lysobacter
sp.
XL1) 		4 / 7 ASN A  65
PRO A  64
PHE A  63
TYR A 198
 NA  A 305 (-3.4A)
None
None
None
 1.48A 5oh3A-5mrtA:
undetectable		 5oh3A-5mrtA:
undetectable