SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 6 LEU A 223
ASP A 276
MET A 215
LEU A 291
 None
 1.25A 1errB-5mrvA:
undetectable		 1errB-5mrvA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_A_ACTA4901_0
(PYRANOSE OXIDASE)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 6 THR A 214
PHE A 212
PHE A 166
ASN A 163
 None
 1.32A 1tt0A-5mrvA:
undetectable		 1tt0A-5mrvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_B_ACTB3901_0
(PYRANOSE OXIDASE)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 6 THR A 214
PHE A 212
PHE A 166
ASN A 163
 None
 1.33A 1tt0B-5mrvA:
undetectable		 1tt0B-5mrvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 6 THR A 214
PHE A 212
PHE A 166
ASN A 163
 None
 1.33A 1tt0C-5mrvA:
1.5		 1tt0C-5mrvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_D_ACTD5901_0
(PYRANOSE OXIDASE)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 6 THR A 214
PHE A 212
PHE A 166
ASN A 163
 None
 1.32A 1tt0D-5mrvA:
0.7		 1tt0D-5mrvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 5 LEU A 223
ASP A 276
MET A 215
LEU A 291
 None
 1.25A 2qxsA-5mrvA:
undetectable		 2qxsA-5mrvA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 5 LEU A 223
ASP A 276
MET A 215
LEU A 291
 None
 1.25A 2qxsB-5mrvA:
undetectable		 2qxsB-5mrvA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		3 / 3 GLU A 290
HIS A  88
GLU A  91
 ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 (-1.9A)
 0.84A 2x45B-5mrvA:
undetectable		 2x45B-5mrvA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		3 / 3 GLU A 290
HIS A  88
GLU A  91
 ZN  A 401 ( 4.6A)
ZN  A 401 (-3.2A)
ZN  A 401 (-1.9A)
 0.86A 2x45C-5mrvA:
undetectable		 2x45C-5mrvA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 8 ALA A 197
TRP A  82
GLY A  57
ILE A  65
 None
 0.81A 2zm9A-5mrvA:
undetectable		 2zm9A-5mrvA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		5 / 11 ILE A  81
PHE A  97
VAL A 126
LYS A  69
ILE A  70
 None
 1.47A 3ijdA-5mrvA:
undetectable		 3ijdA-5mrvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 7 TYR A  30
GLU A 312
TYR A 254
TYR A 258
 None
 1.27A 3ugrA-5mrvA:
undetectable		 3ugrA-5mrvA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		4 / 6 VAL A 126
VAL A 102
ILE A 105
LEU A 321
 None
 0.88A 4l1wB-5mrvA:
undetectable		 4l1wB-5mrvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		5 / 12 GLY A  57
ALA A 197
VAL A 198
LEU A 127
ILE A 132
 None
 1.14A 4pd5A-5mrvA:
undetectable		 4pd5A-5mrvA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 5mrv CARBOXYPEPTIDASE O
(Homo
sapiens) 		5 / 12 GLY A  57
ALA A 197
VAL A 198
LEU A 127
ILE A 132
 None
 1.09A 4pd9A-5mrvA:
undetectable		 4pd9A-5mrvA:
9.81