SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5msx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_A_DVAA6_0
(GRAMICIDIN A)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A  51
VAL A  68
TRP A  69
 None
 0.92A 1bdwA-5msxA:
undetectable
1bdwB-5msxA:
undetectable		 1bdwA-5msxA:
8.05
1bdwB-5msxA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 ASP A 374
GLY A 453
ILE A 454
ILE A 334
 None
 0.85A 1n49D-5msxA:
undetectable		 1n49D-5msxA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 413
SER A 411
TYR A 442
TYR A 330
 None
 1.20A 2bteA-5msxA:
undetectable		 2bteA-5msxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 8 ASP A 413
SER A 411
TYR A 442
TYR A 330
 None
 1.21A 2bteD-5msxA:
undetectable		 2bteD-5msxA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 4 VAL A 291
PHE A  47
VAL A  68
TRP A  69
 None
 1.08A 2y00A-5msxA:
undetectable		 2y00A-5msxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		5 / 11 ALA A  38
LEU A  30
VAL A 291
LEU A 315
PHE A 265
 None
 1.29A 3fl9C-5msxA:
undetectable		 3fl9C-5msxA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		5 / 9 ALA A  38
LEU A  30
VAL A 291
LEU A 315
PHE A 265
 None
 1.24A 3fl9H-5msxA:
undetectable		 3fl9H-5msxA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A  76
SER A 430
ASN A 364
 None
 0.80A 3s8pB-5msxA:
undetectable		 3s8pB-5msxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I90_A_ACTA500_0
(1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 446
ARG A 444
TRP A 417
 None
 1.44A 4i90A-5msxA:
undetectable		 4i90A-5msxA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 310
ARG A 282
ARG A 350
 None
 0.87A 4x5iA-5msxA:
undetectable		 4x5iA-5msxA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A  76
SER A 430
ASN A 364
 None
 0.70A 5cprB-5msxA:
undetectable		 5cprB-5msxA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 169
ALA A 176
MET A 236
LEU A 178
 None
 1.22A 5dzkB-5msxA:
undetectable
5dzkP-5msxA:
undetectable		 5dzkB-5msxA:
17.74
5dzkP-5msxA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 169
ALA A 176
MET A 236
LEU A 178
 None
 1.31A 5dzkg-5msxA:
undetectable
5dzku-5msxA:
undetectable		 5dzkg-5msxA:
17.74
5dzku-5msxA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLY A 258
SER A 248
GLU A 279
ARG A 283
 None
 1.10A 5n5dB-5msxA:
undetectable		 5n5dB-5msxA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 104
VAL A 119
ASP A 121
 None
 0.66A 6fgdA-5msxA:
undetectable		 6fgdA-5msxA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE
(Bacteroides
thetaiotaomicron) 		3 / 3 TRP A  77
ILE A  40
GLU A  42
 None
 0.71A 6hcxA-5msxA:
4.0		 6hcxA-5msxA:
10.32