SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5msy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 ILE A 184
MET A 237
VAL A  88
GLY A 185
 None
 1.40A 1e06B-5msyA:
undetectable		 1e06B-5msyA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 MET A 158
SER A 203
ALA A 165
ALA A 199
 None
 0.97A 1k5qA-5msyA:
undetectable
1k5qB-5msyA:
undetectable		 1k5qA-5msyA:
18.57
1k5qB-5msyA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A 216
VAL A 146
THR A  61
LEU A  65
 None
None
NH3  A 504 ( 2.8A)
None
 1.21A 1oq5A-5msyA:
undetectable		 1oq5A-5msyA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  78
ILE A  89
VAL A  88
ASN A 179
PHE A 332
 None
 1.17A 1wsvA-5msyA:
undetectable		 1wsvA-5msyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A  78
ILE A  89
VAL A  88
ASN A 179
PHE A 332
 None
 1.17A 1wsvB-5msyA:
undetectable		 1wsvB-5msyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ILE A 102
LEU A  65
ALA A  74
GLU A  73
 NH3  A 509 (-4.0A)
None
None
None
 1.22A 1xvaA-5msyA:
undetectable
1xvaB-5msyA:
undetectable		 1xvaA-5msyA:
20.17
1xvaB-5msyA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLU A 284
PRO A 285
ILE A 286
GLY A 241
 NH3  A 504 (-4.4A)
None
None
None
 0.80A 2qeuA-5msyA:
undetectable
2qeuC-5msyA:
undetectable		 2qeuA-5msyA:
14.97
2qeuC-5msyA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLY A  59
GLY A 144
PHE A 235
PHE A 320
 None
None
None
NH3  A 506 ( 4.9A)
 1.02A 2qx6A-5msyA:
undetectable
2qx6B-5msyA:
undetectable		 2qx6A-5msyA:
19.35
2qx6B-5msyA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 315
TRP A 265
TRP A 313
 None
 1.33A 2xdcC-5msyA:
undetectable
2xdcD-5msyA:
undetectable		 2xdcC-5msyA:
3.53
2xdcD-5msyA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  77
TRP A 347
TYR A 356
GLU A 288
 None
 1.11A 2xytD-5msyA:
undetectable		 2xytD-5msyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  77
TRP A 347
TYR A 356
GLU A 288
 None
 1.07A 2xytG-5msyA:
undetectable		 2xytG-5msyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A  77
TRP A 347
TYR A 356
GLU A 288
 None
 1.01A 2xytH-5msyA:
undetectable		 2xytH-5msyA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 GLU A 196
GLY A 186
PHE A 215
PHE A 227
THR A 221
 None
 1.23A 3a3yA-5msyA:
undetectable		 3a3yA-5msyA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ASN A 236
ASP A 282
THR A  61
SER A 223
 None
None
NH3  A 504 ( 2.8A)
None
 1.31A 3p2kC-5msyA:
undetectable		 3p2kC-5msyA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLY A 433
ASP A 432
ARG A 308
MET A 411
 None
 1.50A 3qx3A-5msyA:
undetectable		 3qx3A-5msyA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 282
GLU A 284
GLY A 241
 None
NH3  A 504 (-4.4A)
None
 0.71A 3w9tA-5msyA:
undetectable		 3w9tA-5msyA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 315
TRP A 265
TRP A 313
 None
 1.37A 3zq8A-5msyA:
undetectable
3zq8B-5msyA:
undetectable		 3zq8A-5msyA:
3.53
3zq8B-5msyA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 112
GLY A 167
ALA A 165
ILE A 204
ILE A 184
 None
 1.03A 4aztA-5msyA:
undetectable		 4aztA-5msyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 322
GLY A 283
HIS A 242
GLY A 325
TYR A 287
 None
None
None
NH3  A 505 (-3.5A)
NH3  A 504 (-4.4A)
 1.21A 4bz6C-5msyA:
undetectable		 4bz6C-5msyA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 135
LEU A  78
THR A  61
MET A 330
 None
None
NH3  A 504 ( 2.8A)
None
 1.47A 4mbsB-5msyA:
undetectable		 4mbsB-5msyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 235
PHE A 320
PHE A  56
GLY A  59
 None
NH3  A 506 ( 4.9A)
None
None
 1.00A 4qoiA-5msyA:
undetectable
4qoiB-5msyA:
undetectable		 4qoiA-5msyA:
19.31
4qoiB-5msyA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 442
HIS A 446
LYS A 423
 None
 1.00A 4qzuD-5msyA:
undetectable		 4qzuD-5msyA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 TYR A 112
GLY A 167
ALA A 165
ILE A 204
ILE A 184
 None
 1.01A 4uw0A-5msyA:
undetectable		 4uw0A-5msyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 218
GLN A 239
PRO A 217
ILE A 188
 PO4  A 501 ( 4.7A)
None
None
None
 1.34A 4z4hA-5msyA:
undetectable		 4z4hA-5msyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 MET A 366
LEU A 362
GLY A 355
GLN A 358
MET A 359
 None
 1.47A 4zp0A-5msyA:
undetectable		 4zp0A-5msyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZP0_A_DXCA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A 404
MET A 366
GLY A 355
GLN A 358
MET A 359
 None
 1.39A 4zp0A-5msyA:
undetectable		 4zp0A-5msyA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 11 TRP A 427
GLY A 408
ALA A 392
TYR A 389
ASN A 458
 None
 1.43A 5c8tB-5msyA:
undetectable		 5c8tB-5msyA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 VAL A 472
GLN A 478
CYH A 476
 None
 0.81A 5icxA-5msyA:
undetectable
5icxE-5msyA:
undetectable		 5icxA-5msyA:
18.70
5icxE-5msyA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_B_ACTB713_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		3 / 3 GLY A 156
GLN A 162
LYS A 193
 None
 0.83A 5imsB-5msyA:
undetectable		 5imsB-5msyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ARG A 218
GLN A 239
PRO A 217
ILE A 188
 PO4  A 501 ( 4.7A)
None
None
None
 1.40A 5ki6A-5msyA:
undetectable		 5ki6A-5msyA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ASP A 282
PHE A 267
GLY A 219
GLY A 241
 None
 0.85A 5n9xA-5msyA:
undetectable		 5n9xA-5msyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 144
GLN A  90
LEU A  78
ILE A 133
MET A 129
 None
NH3  A 504 ( 4.4A)
None
None
None
 0.72A 5y2tA-5msyA:
undetectable		 5y2tA-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		6 / 12 LEU A 170
GLY A 144
GLN A  90
TYR A  77
LEU A  78
ILE A 133
 None
None
NH3  A 504 ( 4.4A)
None
None
None
 1.10A 5y2tA-5msyA:
undetectable		 5y2tA-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 170
GLN A  90
TYR A  77
LEU A  78
ILE A 133
 None
NH3  A 504 ( 4.4A)
None
None
None
 1.16A 5y2tB-5msyA:
undetectable		 5y2tB-5msyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLN A 162
VAL A 160
ALA A 195
THR A 194
 None
 1.04A 6cduB-5msyA:
undetectable
6cduC-5msyA:
undetectable		 6cduB-5msyA:
19.01
6cduC-5msyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5msy GLYCOSIDE HYDROLASE
(Bacteroides
thetaiotaomicron) 		5 / 10 TYR A 324
ALA A 311
LEU A 362
LEU A  58
TYR A  86
 None
 1.38A 6g2pB-5msyA:
undetectable		 6g2pB-5msyA:
19.88