SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mtf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		5 / 12 ALA A  93
GLY A 162
GLY A 163
LEU A 200
PHE A 153
 CL  A 302 ( 3.6A)
None
BNG  A 306 (-3.4A)
None
None
 0.98A 1eizA-5mtfA:
undetectable		 1eizA-5mtfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		5 / 12 ALA A  93
GLY A 162
GLY A 163
LEU A 200
PHE A 153
 CL  A 302 ( 3.6A)
None
BNG  A 306 (-3.4A)
None
None
 0.99A 1ej0A-5mtfA:
undetectable		 1ej0A-5mtfA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		4 / 6 GLY A 257
GLY A 186
TYR A 187
SER A 201
 None
 0.96A 1eswA-5mtfA:
undetectable		 1eswA-5mtfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		5 / 12 ILE A 230
GLY A 209
ALA A 263
GLY A 215
LEU A 270
 BNG  A 304 (-4.6A)
BNG  A 304 ( 4.2A)
None
None
None
 1.14A 1kiaC-5mtfA:
undetectable		 1kiaC-5mtfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		4 / 8 GLY A 202
SER A 185
TRP A 158
HIS A 141
 None
 1.10A 1maaD-5mtfA:
undetectable		 1maaD-5mtfA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		5 / 12 GLY A 257
LEU A 258
TRP A 158
LEU A 229
ALA A 206
 None
BNG  A 305 ( 4.4A)
None
None
None
 1.01A 3av6A-5mtfA:
undetectable		 3av6A-5mtfA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		5 / 12 ALA A 263
GLY A 209
GLY A 261
GLY A 257
LEU A 225
 None
BNG  A 304 ( 4.2A)
None
None
None
 1.05A 5c0oH-5mtfA:
undetectable		 5c0oH-5mtfA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5mtf RHOMBOID PROTEASE
GLPG
(Escherichia
coli) 		5 / 12 VAL A 203
LEU A 179
ALA A 182
SER A 185
LEU A 143
 None
 1.16A 5nd7B-5mtfA:
undetectable		 5nd7B-5mtfA:
15.13