SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mtj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5mtj TYROSINE-PROTEIN
KINASE YES
MONOBODY MB(YES_1)
(Mus
musculus;
Homo
sapiens) 		4 / 6 TYR B  82
SER A 158
ALA A 164
THR A 160
 None
SO4  A 301 (-2.7A)
None
SO4  A 301 (-2.7A)
 1.14A 1yvpB-5mtjB:
undetectable		 1yvpB-5mtjB:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5mtj MONOBODY MB(YES_1)
(Homo
sapiens) 		4 / 7 PRO B   5
VAL B   4
SER B   3
GLU B  86
 None
 1.08A 2v2gA-5mtjB:
undetectable
2v2gB-5mtjB:
undetectable		 2v2gA-5mtjB:
18.92
2v2gB-5mtjB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPW_A_NCAA412_0
(OLD YELLOW ENZYME
2.6 (OYE2.6), NADPH
DEHYDROGENASE)		 5mtj TYROSINE-PROTEIN
KINASE YES
MONOBODY MB(YES_1)
(Mus
musculus;
Homo
sapiens) 		5 / 9 ALA A 199
HIS A 210
HIS A 214
TYR A 211
TYR B  73
 None
 1.35A 3upwA-5mtjA:
undetectable		 3upwA-5mtjA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 5mtj TYROSINE-PROTEIN
KINASE YES
MONOBODY MB(YES_1)
(Mus
musculus;
Homo
sapiens) 		4 / 6 HIS A 210
HIS A 214
TYR A 211
TYR B  73
 None
 1.36A 4df2A-5mtjA:
undetectable		 4df2A-5mtjA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5mtj TYROSINE-PROTEIN
KINASE YES
(Mus
musculus) 		3 / 3 ARG A 186
LYS A 184
ARG A 176
 None
SO4  A 301 (-3.9A)
None
 1.10A 6c06D-5mtjA:
undetectable		 6c06D-5mtjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5mtj MONOBODY MB(YES_1)
(Homo
sapiens) 		4 / 7 ILE B  70
VAL B  10
ALA B  13
THR B  14
 None
None
None
CXS  B 102 (-3.7A)
 0.95A 6cduC-5mtjB:
undetectable
6cduD-5mtjB:
2.0		 6cduC-5mtjB:
16.98
6cduD-5mtjB:
16.98