SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mtz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 THR A 487
THR A 470
THR A 723
HIS A 545
 None
None
None
ZN  A 902 (-3.4A)
 1.37A 1d4fB-5mtzA:
undetectable		 1d4fB-5mtzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 545
HIS A 670
HIS A 759
ASP A 544
 ZN  A 902 (-3.4A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
ZN  A 902 ( 2.6A)
 0.94A 1e9yB-5mtzA:
undetectable		 1e9yB-5mtzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 699
HIS A 759
HIS A 540
HIS A 545
 ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
ZN  A 901 (-3.4A)
ZN  A 902 (-3.4A)
 1.21A 1ei6A-5mtzA:
undetectable		 1ei6A-5mtzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 587
ILE A 550
TRP A 583
GLY A  67
ALA A 543
 None
 1.35A 1hvyB-5mtzA:
undetectable		 1hvyB-5mtzA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 347
PRO A 350
THR A 473
ARG A 482
 None
 1.30A 1i2wA-5mtzA:
undetectable		 1i2wA-5mtzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 188
PHE A 146
ASN A  90
ILE A 115
ILE A  92
 None
 1.17A 1j3jA-5mtzA:
undetectable		 1j3jA-5mtzA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 699
HIS A 759
HIS A 737
 ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
PO4  A 903 (-4.3A)
 0.58A 1oe1A-5mtzA:
undetectable		 1oe1A-5mtzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 699
HIS A 759
HIS A 737
 ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
PO4  A 903 (-4.3A)
 0.57A 1oe3A-5mtzA:
undetectable		 1oe3A-5mtzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 337
ARG A 519
ILE A 327
PHE A 423
ILE A 428
 None
 1.43A 1ot7B-5mtzA:
undetectable		 1ot7B-5mtzA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 789
VAL A 790
THR A 336
THR A 470
ILE A 468
 None
 1.22A 1pkvA-5mtzA:
undetectable
1pkvB-5mtzA:
undetectable		 1pkvA-5mtzA:
9.06
1pkvB-5mtzA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 386
LEU A 298
PHE A 299
ILE A 322
ILE A 391
 None
 0.98A 1rx7A-5mtzA:
undetectable		 1rx7A-5mtzA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 755
LEU A 718
SER A 695
SER A 678
 None
 0.95A 1tz8C-5mtzA:
undetectable
1tz8D-5mtzA:
undetectable		 1tz8C-5mtzA:
10.04
1tz8D-5mtzA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 170
SER A 676
TYR A 675
 None
 0.50A 1x70A-5mtzA:
undetectable		 1x70A-5mtzA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 484
ASP A 544
SER A 539
ILE A 568
TYR A 576
 None
ZN  A 902 ( 2.6A)
None
None
None
 1.34A 1xvaA-5mtzA:
2.0		 1xvaA-5mtzA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 THR A  99
PRO A  70
TYR A  95
ILE A  96
LEU A 186
 None
 1.16A 1z9hA-5mtzA:
undetectable		 1z9hA-5mtzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 THR A  99
PRO A  70
TYR A  95
ILE A  96
LEU A 186
 None
 1.17A 1z9hB-5mtzA:
undetectable		 1z9hB-5mtzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 THR A  99
PRO A  70
TYR A  95
ILE A  96
LEU A 186
 None
 1.15A 1z9hC-5mtzA:
undetectable		 1z9hC-5mtzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 THR A  99
PRO A  70
TYR A  95
ILE A  96
LEU A 186
 None
 1.16A 1z9hD-5mtzA:
undetectable		 1z9hD-5mtzA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 536
HIS A 540
ASP A 699
GLY A 698
TYR A 696
 None
ZN  A 901 (-3.4A)
ZN  A 902 (-2.3A)
None
None
 1.17A 1zz1A-5mtzA:
undetectable		 1zz1A-5mtzA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BL9_A_CP6A1240_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 660
MET A 683
PHE A 681
SER A 695
ILE A 679
 None
 1.17A 2bl9A-5mtzA:
undetectable		 2bl9A-5mtzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 490
ASP A 454
ASN A 457
 None
 1.10A 2bm9A-5mtzA:
undetectable		 2bm9A-5mtzA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_B_DZPB2001_1
(SERUM ALBUMIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 718
ILE A 756
PHE A 692
VAL A 489
LEU A 507
 None
 1.15A 2bxfB-5mtzA:
undetectable		 2bxfB-5mtzA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 7 SER A 328
SER A  12
THR A  11
ASN A 325
 None
 0.82A 2i91A-5mtzA:
undetectable		 2i91A-5mtzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 7 SER A 328
SER A  12
THR A  11
ASN A 325
 None
 0.82A 2i91B-5mtzA:
undetectable		 2i91B-5mtzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 389
ASN A 390
THR A 384
 None
 0.57A 2pymB-5mtzA:
undetectable		 2pymB-5mtzA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 544
ASP A 699
HIS A 759
SER A 761
 ZN  A 902 ( 2.6A)
ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
None
 0.81A 2q0iA-5mtzA:
7.3		 2q0iA-5mtzA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 544
HIS A 670
ASP A 699
HIS A 759
SER A 761
 ZN  A 902 ( 2.6A)
ZN  A 901 ( 3.5A)
ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
None
 0.83A 2q0jA-5mtzA:
7.3		 2q0jA-5mtzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		6 / 11 ASP A 544
HIS A 545
HIS A 670
ASP A 699
HIS A 759
SER A 761
 ZN  A 902 ( 2.6A)
ZN  A 902 (-3.4A)
ZN  A 901 ( 3.5A)
ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
None
 0.80A 2q0jB-5mtzA:
7.5		 2q0jB-5mtzA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 428
PHE A 809
GLY A 331
ILE A 327
 None
 0.85A 2qwxA-5mtzA:
undetectable
2qwxB-5mtzA:
undetectable		 2qwxA-5mtzA:
12.91
2qwxB-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 698
TYR A 696
SER A 539
 None
 0.70A 2xatA-5mtzA:
undetectable		 2xatA-5mtzA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 699
HIS A 759
HIS A 737
 ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
PO4  A 903 (-4.3A)
 0.59A 2xxgA-5mtzA:
undetectable		 2xxgA-5mtzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 699
HIS A 759
HIS A 737
 ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
PO4  A 903 (-4.3A)
 0.60A 2xxgC-5mtzA:
undetectable		 2xxgC-5mtzA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 7 MET A 316
VAL A 400
ILE A 416
TYR A 285
 None
 1.10A 2yfbA-5mtzA:
undetectable		 2yfbA-5mtzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 TYR A  88
VAL A 192
THR A  58
 None
 0.76A 2ygnA-5mtzA:
undetectable		 2ygnA-5mtzA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 6 VAL A 181
ASP A 176
LYS A 160
HIS A 178
 None
 1.42A 2zs9A-5mtzA:
undetectable		 2zs9A-5mtzA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 784
THR A 487
ILE A 468
THR A 470
 None
 0.89A 3bpxA-5mtzA:
undetectable
3bpxB-5mtzA:
undetectable		 3bpxA-5mtzA:
10.81
3bpxB-5mtzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 172
HIS A 545
HIS A 540
ASP A 544
 None
ZN  A 902 (-3.4A)
ZN  A 901 (-3.4A)
ZN  A 902 ( 2.6A)
 1.17A 3c0zC-5mtzA:
undetectable		 3c0zC-5mtzA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 347
GLY A 472
SER A 479
ASP A 544
HIS A 545
 None
None
None
ZN  A 902 ( 2.6A)
ZN  A 902 (-3.4A)
 1.23A 3dlcA-5mtzA:
undetectable		 3dlcA-5mtzA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 499
ASP A 532
GLN A 531
 None
 0.74A 3eeyC-5mtzA:
undetectable		 3eeyC-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 499
ASP A 532
GLN A 531
 None
 0.74A 3eeyD-5mtzA:
undetectable		 3eeyD-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 499
ASP A 532
GLN A 531
 None
 0.75A 3eeyE-5mtzA:
undetectable		 3eeyE-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 521
GLU A 555
LEU A 488
LEU A 471
ILE A 469
 None
 1.30A 3kvrA-5mtzA:
undetectable		 3kvrA-5mtzA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 466
PHE A 456
ILE A 789
PHE A 521
 None
 1.04A 3owxB-5mtzA:
undetectable		 3owxB-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 491
PHE A 456
ILE A 469
PHE A 521
 None
 0.99A 3owxB-5mtzA:
undetectable		 3owxB-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 SER A  98
ARG A 101
TYR A 102
VAL A 104
 None
 1.24A 3sufC-5mtzA:
undetectable		 3sufC-5mtzA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.48A 3w9tA-5mtzA:
undetectable		 3w9tA-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.47A 3w9tB-5mtzA:
undetectable		 3w9tB-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.48A 3w9tC-5mtzA:
undetectable		 3w9tC-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.48A 3w9tD-5mtzA:
undetectable		 3w9tD-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.48A 3w9tE-5mtzA:
undetectable		 3w9tE-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.49A 3w9tF-5mtzA:
undetectable		 3w9tF-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 ASP A 544
VAL A 484
GLY A 474
ASP A 699
 ZN  A 902 ( 2.6A)
None
None
ZN  A 902 (-2.3A)
 1.48A 3w9tG-5mtzA:
undetectable		 3w9tG-5mtzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 540
HIS A 542
ASP A 544
HIS A 670
HIS A 759
 ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.6A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
 0.80A 4c1dB-5mtzA:
5.6		 4c1dB-5mtzA:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 540
HIS A 542
ASP A 544
HIS A 670
HIS A 759
 ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.6A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
 0.83A 4c1fA-5mtzA:
4.9
4c1fB-5mtzA:
6.6		 4c1fA-5mtzA:
13.70
4c1fB-5mtzA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 9 HIS A 540
HIS A 542
ASP A 544
HIS A 670
HIS A 759
 ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.6A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
 0.81A 4c1hA-5mtzA:
7.0		 4c1hA-5mtzA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 542
ASP A 544
HIS A 670
HIS A 759
 ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.6A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
 0.78A 4exsB-5mtzA:
5.3		 4exsB-5mtzA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  84
LEU A  86
LEU A  93
ILE A  76
VAL A 104
 None
 1.13A 4f4dB-5mtzA:
undetectable		 4f4dB-5mtzA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 545
HIS A 670
HIS A 759
ASP A 544
 ZN  A 902 (-3.4A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
ZN  A 902 ( 2.6A)
 0.96A 4h9mA-5mtzA:
undetectable		 4h9mA-5mtzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 7 ASP A  13
THR A 516
PHE A 329
SER A 332
 None
 1.01A 4o4dA-5mtzA:
undetectable		 4o4dA-5mtzA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 737
HIS A 759
HIS A 540
HIS A 542
 PO4  A 903 (-4.3A)
ZN  A 902 ( 3.2A)
ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
 0.98A 4p6sB-5mtzA:
undetectable		 4p6sB-5mtzA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 386
LEU A 298
PHE A 299
ILE A 322
ILE A 391
 None
 1.12A 4ptjA-5mtzA:
undetectable		 4ptjA-5mtzA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 428
PHE A 809
GLY A 331
ILE A 327
 None
 0.84A 4qogA-5mtzA:
undetectable
4qogB-5mtzA:
undetectable		 4qogA-5mtzA:
12.91
4qogB-5mtzA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 792
ARG A 753
LYS A 754
 None
 1.34A 4wq5B-5mtzA:
undetectable		 4wq5B-5mtzA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 257
PHE A  31
ILE A 127
ILE A 198
THR A 194
 None
 1.08A 4x5jA-5mtzA:
undetectable		 4x5jA-5mtzA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		6 / 11 HIS A 540
HIS A 542
ASP A 544
HIS A 545
HIS A 670
HIS A 759
 ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.6A)
ZN  A 902 (-3.4A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
 0.29A 5ayaA-5mtzA:
8.1		 5ayaA-5mtzA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 6 SER A 174
GLY A 698
THR A 723
GLU A 721
 None
 1.09A 5btaA-5mtzA:
undetectable
5btaB-5mtzA:
undetectable
5btaC-5mtzA:
undetectable		 5btaA-5mtzA:
18.60
5btaB-5mtzA:
15.67
5btaC-5mtzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 6 SER A 174
GLY A 698
THR A 723
GLU A 721
 None
 1.06A 5btcA-5mtzA:
undetectable
5btcC-5mtzA:
undetectable
5btcD-5mtzA:
undetectable		 5btcA-5mtzA:
18.60
5btcC-5mtzA:
18.60
5btcD-5mtzA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 6 SER A 174
GLY A 698
THR A 723
GLU A 721
 None
 1.07A 5btcA-5mtzA:
undetectable
5btcB-5mtzA:
undetectable
5btcC-5mtzA:
undetectable		 5btcA-5mtzA:
18.60
5btcB-5mtzA:
15.67
5btcC-5mtzA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 SER A 174
GLY A 698
THR A 723
GLU A 721
 None
 1.13A 5btiA-5mtzA:
undetectable
5btiB-5mtzA:
undetectable		 5btiA-5mtzA:
18.60
5btiB-5mtzA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 5 SER A 174
GLY A 698
THR A 723
GLU A 721
 None
 1.14A 5btiC-5mtzA:
undetectable
5btiD-5mtzA:
undetectable		 5btiC-5mtzA:
18.60
5btiD-5mtzA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 573
SER A 676
HIS A 759
GLY A 698
ASP A 544
 None
None
ZN  A 902 ( 3.2A)
None
ZN  A 902 ( 2.6A)
 1.36A 5eeiA-5mtzA:
undetectable		 5eeiA-5mtzA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 573
SER A 676
HIS A 759
GLY A 698
ASP A 544
 None
None
ZN  A 902 ( 3.2A)
None
ZN  A 902 ( 2.6A)
 1.36A 5eeiB-5mtzA:
undetectable		 5eeiB-5mtzA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 780
LEU A 717
LYS A 754
ASP A 791
VAL A 489
 None
 1.36A 5kbwB-5mtzA:
undetectable		 5kbwB-5mtzA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 GLU A 780
LEU A 717
LYS A 754
ASP A 791
VAL A 491
 None
 1.33A 5kbwB-5mtzA:
undetectable		 5kbwB-5mtzA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		6 / 10 HIS A 540
HIS A 542
HIS A 545
HIS A 670
ASP A 699
HIS A 737
 ZN  A 901 (-3.4A)
ZN  A 901 ( 3.1A)
ZN  A 902 (-3.4A)
ZN  A 901 ( 3.5A)
ZN  A 902 (-2.3A)
PO4  A 903 (-4.3A)
 0.38A 5nzwA-5mtzA:
6.8		 5nzwA-5mtzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 545
HIS A 759
HIS A 540
ASP A 699
HIS A 670
 ZN  A 902 (-3.4A)
ZN  A 902 ( 3.2A)
ZN  A 901 (-3.4A)
ZN  A 902 (-2.3A)
ZN  A 901 ( 3.5A)
 1.07A 5nzwA-5mtzA:
6.8		 5nzwA-5mtzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 10 HIS A 670
HIS A 540
HIS A 737
ASP A 699
HIS A 759
 ZN  A 901 ( 3.5A)
ZN  A 901 (-3.4A)
PO4  A 903 (-4.3A)
ZN  A 902 (-2.3A)
ZN  A 902 ( 3.2A)
 0.96A 5nzwA-5mtzA:
6.8		 5nzwA-5mtzA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  92
LEU A  61
LEU A 183
PHE A 579
GLY A  68
 None
 1.09A 5uxdB-5mtzA:
undetectable		 5uxdB-5mtzA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 820
ARG A 763
LEU A 339
PHE A 785
ALA A 784
 None
 1.18A 5vc0A-5mtzA:
undetectable		 5vc0A-5mtzA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 781
CYH A 782
ILE A 468
LEU A 770
LEU A 767
 None
 1.45A 5ycpA-5mtzA:
undetectable		 5ycpA-5mtzA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 545
HIS A 759
HIS A 670
SER A 539
PRO A 702
 ZN  A 902 (-3.4A)
ZN  A 902 ( 3.2A)
ZN  A 901 ( 3.5A)
None
None
 1.33A 5z0kA-5mtzA:
undetectable
5z0kB-5mtzA:
undetectable		 5z0kA-5mtzA:
6.51
5z0kB-5mtzA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 545
HIS A 759
HIS A 737
HIS A 670
PRO A 702
 ZN  A 902 (-3.4A)
ZN  A 902 ( 3.2A)
PO4  A 903 (-4.3A)
ZN  A 901 ( 3.5A)
None
 1.35A 5z0mA-5mtzA:
undetectable
5z0mB-5mtzA:
undetectable		 5z0mA-5mtzA:
6.40
5z0mB-5mtzA:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 542
ASP A 544
HIS A 670
HIS A 759
 ZN  A 901 ( 3.1A)
ZN  A 902 ( 2.6A)
ZN  A 901 ( 3.5A)
ZN  A 902 ( 3.2A)
 0.84A 5zj8A-5mtzA:
3.6		 5zj8A-5mtzA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 THR A 739
ALA A 732
LYS A 734
 None
 0.49A 6fgcA-5mtzA:
undetectable		 6fgcA-5mtzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		3 / 3 THR A 739
ALA A 732
LYS A 734
 None
 0.50A 6fgdA-5mtzA:
undetectable		 6fgdA-5mtzA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5mtz RIBONUCLEASE Z
(Saccharomyces
cerevisiae) 		4 / 8 ASP A  65
HIS A 518
ASP A 290
GLU A 291
 None
 1.15A 6mn4C-5mtzA:
undetectable		 6mn4C-5mtzA:
15.64