SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		5 / 11 LEU A 124
VAL A 155
ILE A 180
ILE A 187
ILE A 137
 None
 0.86A 1c6yA-5mu3A:
undetectable		 1c6yA-5mu3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19
(Kluyveromyces
lactis) 		4 / 5 VAL E 223
THR E 242
GLN E 246
ILE E 253
 None
 1.46A 1ss4A-5mu3E:
undetectable		 1ss4A-5mu3E:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		4 / 6 ILE A 187
CYH A 205
LEU A 124
ILE A 137
 None
 1.03A 2q83B-5mu3A:
undetectable		 2q83B-5mu3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		5 / 12 LEU A 124
VAL A 155
ILE A 180
ILE A 187
ILE A 137
 None
 0.87A 2r5pA-5mu3A:
undetectable		 2r5pA-5mu3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		5 / 12 LEU A 124
VAL A 155
ILE A 180
ILE A 187
ILE A 137
 None
 0.88A 2r5pC-5mu3A:
undetectable		 2r5pC-5mu3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19
(Kluyveromyces
lactis) 		5 / 12 VAL E 186
ILE E 169
ALA E 172
THR E 175
ASN E 179
 None
 1.16A 3ddyA-5mu3E:
undetectable		 3ddyA-5mu3E:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19
(Kluyveromyces
lactis) 		5 / 11 LEU E 133
LEU E 158
ALA E 140
MET E 154
ALA E 172
 None
 1.21A 3e22B-5mu3E:
undetectable		 3e22B-5mu3E:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19
(Kluyveromyces
lactis) 		5 / 11 LEU E 133
LEU E 158
ALA E 140
MET E 154
ALA E 172
 None
 1.23A 3e22D-5mu3E:
undetectable		 3e22D-5mu3E:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		5 / 9 LEU A 124
VAL A 155
ILE A 180
ILE A 187
ILE A 137
 None
 0.92A 3ekqB-5mu3A:
undetectable		 3ekqB-5mu3A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		4 / 5 LEU A 222
ARG A 247
ILE A 253
PHE A 246
 None
 1.26A 3ln1D-5mu3A:
0.7		 3ln1D-5mu3A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		3 / 3 ARG A 247
ILE A 253
PHE A 246
 None
 0.75A 5kirA-5mu3A:
undetectable		 5kirA-5mu3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		5 / 9 LEU A 124
VAL A 155
ILE A 180
ILE A 187
ILE A 137
 None
 0.79A 5kqxB-5mu3A:
undetectable		 5kqxB-5mu3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT CTF19
(Kluyveromyces
lactis) 		4 / 8 GLN E 259
GLY E 257
ILE E 240
ASP E 250
 None
 0.98A 5vlmH-5mu3E:
undetectable		 5vlmH-5mu3E:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		5 / 12 LEU A 124
VAL A 155
ILE A 180
ILE A 187
ILE A 137
 None
 0.91A 6difB-5mu3A:
undetectable		 6difB-5mu3A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 5mu3 CENTRAL KINETOCHORE
SUBUNIT MCM21
(Kluyveromyces
lactis) 		4 / 6 GLU A 114
ARG A 138
PHE A 125
PRO A 126
 None
 1.25A 6fgdA-5mu3A:
undetectable		 6fgdA-5mu3A:
17.88