SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5muf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 SER A 289
ASN A 256
ARG A 104
GLY A 124
THR A 121
 None
None
PO4  A 301 (-4.1A)
None
None
 1.49A 1jr1A-5mufA:
undetectable		 1jr1A-5mufA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_B_HSMB402_1
(NITROPHORIN 1)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 GLU A 129
THR A 121
LEU A 123
LEU A 120
 None
 1.22A 1u18B-5mufA:
undetectable		 1u18B-5mufA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 123
GLY A 124
HIS A 163
THR A 131
ILE A 160
 None
 1.46A 1z95A-5mufA:
undetectable		 1z95A-5mufA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 THR A 131
ILE A 286
LEU A 254
ILE A 234
 None
 0.79A 4r38A-5mufA:
undetectable		 4r38A-5mufA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 242
LEU A 252
THR A 260
LEU A 275
LEU A 272
 None
 0.92A 4z91A-5mufA:
undetectable
4z91B-5mufA:
undetectable
4z91C-5mufA:
undetectable
4z91D-5mufA:
undetectable
4z91E-5mufA:
undetectable		 4z91A-5mufA:
21.69
4z91B-5mufA:
21.69
4z91C-5mufA:
21.69
4z91D-5mufA:
21.69
4z91E-5mufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 252
THR A 260
LEU A 275
LEU A 272
LEU A 242
 None
 1.01A 4z91A-5mufA:
undetectable
4z91B-5mufA:
undetectable
4z91C-5mufA:
undetectable
4z91D-5mufA:
undetectable
4z91E-5mufA:
undetectable		 4z91A-5mufA:
21.69
4z91B-5mufA:
21.69
4z91C-5mufA:
21.69
4z91D-5mufA:
21.69
4z91E-5mufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 LEU A 272
LEU A 242
LEU A 252
THR A 260
LEU A 275
 None
 0.97A 4z91A-5mufA:
undetectable
4z91B-5mufA:
undetectable
4z91C-5mufA:
undetectable
4z91D-5mufA:
undetectable
4z91E-5mufA:
undetectable		 4z91A-5mufA:
21.69
4z91B-5mufA:
21.69
4z91C-5mufA:
21.69
4z91D-5mufA:
21.69
4z91E-5mufA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_A_ASCA1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 HIS A 109
VAL A 110
GLN A 107
HIS A 105
 None
None
None
PO4  A 301 (-3.9A)
 1.48A 5kkzA-5mufA:
undetectable
5kkzG-5mufA:
undetectable		 5kkzA-5mufA:
18.51
5kkzG-5mufA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_D_GLYD713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 5muf SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PGAM5, MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 ARG A 273
HIS A  99
ARG A 265
 None
 0.86A 6dwdD-5mufA:
undetectable		 6dwdD-5mufA:
17.88