SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mul'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 362
VAL A 364
TRP A 369
 None
 0.93A 1nrmA-5mulA:
undetectable		 1nrmA-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 362
VAL A 364
TRP A 369
 None
 0.93A 1nrmB-5mulA:
undetectable		 1nrmB-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 362
VAL A 364
TRP A 369
 None
 0.61A 1nt5A-5mulA:
undetectable		 1nt5A-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 362
VAL A 364
TRP A 369
 None
 0.61A 1nt5B-5mulA:
undetectable		 1nt5B-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.07A 1pxxC-5mulA:
undetectable		 1pxxC-5mulA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 PRO A 281
ASP A 276
ASP A 303
 None
 0.78A 1sqfA-5mulA:
undetectable		 1sqfA-5mulA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 153
TYR A 173
GLU A 100
 None
 0.87A 1vm1A-5mulA:
undetectable		 1vm1A-5mulA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ALA A 275
VAL A 337
TRP A 391
 None
 0.98A 2izqA-5mulA:
undetectable
2izqB-5mulA:
undetectable		 2izqA-5mulA:
2.74
2izqB-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASN A 398
HIS A 386
VAL A 337
 None
 0.87A 3elzB-5mulA:
3.4		 3elzB-5mulA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 257
TYR A 246
ILE A 250
 None
 0.81A 3eteA-5mulA:
undetectable
3eteB-5mulA:
undetectable		 3eteA-5mulA:
23.13
3eteB-5mulA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 CYH A 117
PHE A 156
PHE A 146
PHE A 107
 None
 1.42A 3hggA-5mulA:
undetectable		 3hggA-5mulA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.04A 3n8yB-5mulA:
undetectable		 3n8yB-5mulA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 297
ASP A 373
ASP A 349
 None
 0.81A 3r24A-5mulA:
undetectable		 3r24A-5mulA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 156
TYR A 173
LEU A 187
ARG A 172
 None
 1.43A 3sudD-5mulA:
undetectable		 3sudD-5mulA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U8Q_A_NPUA7231_1
(LACTOTRANSFERRIN)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 GLY A 279
PRO A 281
ASN A 280
TYR A 282
 None
 1.23A 3u8qA-5mulA:
undetectable		 3u8qA-5mulA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZS3_A_ACTA1227_0
(THAUMATIN-LIKE
PROTEIN)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 THR A 271
ARG A 333
ASN A 223
ILE A 268
 None
 1.24A 3zs3A-5mulA:
0.0		 3zs3A-5mulA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.02A 4otyB-5mulA:
undetectable		 4otyB-5mulA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.01A 4rrwD-5mulA:
undetectable		 4rrwD-5mulA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.01A 4rrzD-5mulA:
undetectable		 4rrzD-5mulA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.01A 4rs0A-5mulA:
undetectable		 4rs0A-5mulA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A  51
SER A  44
ILE A  93
LEU A  65
GLY A  66
 None
 0.94A 4yvgA-5mulA:
undetectable		 4yvgA-5mulA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		5 / 11 ILE A 343
THR A 361
TYR A 282
TRP A 301
ASP A 276
 None
 1.36A 5albH-5mulA:
undetectable		 5albH-5mulA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_2
(CYTOCHROME P450 3A4)		 5mul NEURAMINIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 ARG A 215
ARG A 194
ILE A 250
THR A 251
 None
 1.08A 5vceA-5mulA:
undetectable		 5vceA-5mulA:
22.64