SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mus'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5mus L PROTEIN
(California
reptarenavirus) 		3 / 3 VAL A2013
VAL A2004
TRP A2030
 None
 0.95A 1bdwA-5musA:
undetectable
1bdwB-5musA:
undetectable		 1bdwA-5musA:
3.40
1bdwB-5musA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_A_ESTA351_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5mus L PROTEIN
(California
reptarenavirus) 		5 / 12 VAL A1975
LEU A2003
TYR A1966
PHE A1985
VAL A2027
 None
 1.03A 1fduA-5musA:
undetectable		 1fduA-5musA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 5mus L PROTEIN
(California
reptarenavirus) 		5 / 10 GLN A1918
LEU A1907
LEU A1902
SER A1747
LEU A1748
 GOL  A2101 (-3.6A)
None
None
None
None
 1.37A 2ceoB-5musA:
undetectable		 2ceoB-5musA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5mus L PROTEIN
(California
reptarenavirus) 		5 / 9 LEU A2025
SER A2001
THR A2002
LEU A2003
ILE A1995
 None
 1.21A 4ubsA-5musA:
undetectable		 4ubsA-5musA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5mus L PROTEIN
(California
reptarenavirus) 		4 / 6 TYR A1787
PRO A1746
GLU A1792
TYR A1776
 None
 1.42A 4z4cA-5musA:
undetectable		 4z4cA-5musA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_B_ACTB302_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 5mus L PROTEIN
(California
reptarenavirus) 		4 / 5 GLU A1792
TYR A1776
TYR A1787
ARG A1784
 None
 1.34A 5mthA-5musA:
undetectable
5mthB-5musA:
undetectable		 5mthA-5musA:
21.57
5mthB-5musA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_H_ACTH304_0
(ANTIBODY FAB HEAVY
CHAIN
ANTIBODY FAB LIGHT
CHAIN)		 5mus L PROTEIN
(California
reptarenavirus) 		4 / 5 GLU A1792
TYR A1776
TYR A1787
ARG A1784
 None
 1.31A 5mthH-5musA:
undetectable
5mthL-5musA:
undetectable		 5mthH-5musA:
21.57
5mthL-5musA:
21.36