SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 11 LEU A 165
ALA A 189
ALA A 193
LEU A 150
GLN A 147
 None
 1.36A 1iiuA-5muxA:
undetectable		 1iiuA-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 GLU A  24
ARG A 418
ASP A  95
ILE A 141
THR A  27
 None
 1.44A 1kijA-5muxA:
undetectable		 1kijA-5muxA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 LEU A 458
TYR A 455
LEU A  37
LEU A 109
MET A 140
 None
 1.44A 1p33C-5muxA:
undetectable		 1p33C-5muxA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 7 GLU A 282
ILE A 321
TRP A 102
LEU A  98
 TLA  A 501 (-3.4A)
None
None
None
 1.36A 1q0yH-5muxA:
undetectable
1q0yL-5muxA:
undetectable		 1q0yH-5muxA:
20.88
1q0yL-5muxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		3 / 3 HIS A 284
ASP A 334
ASN A 329
 None
 0.73A 1wg8B-5muxA:
undetectable		 1wg8B-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_2
(ESTROGEN RECEPTOR)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 4 LEU A 458
THR A 457
ILE A 448
HIS A 447
 None
 1.26A 2jfaB-5muxA:
undetectable		 2jfaB-5muxA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 11 LEU A 109
VAL A 167
GLN A 147
ILE A  88
ALA A 217
 None
 1.13A 2q72A-5muxA:
undetectable		 2q72A-5muxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 LEU A 109
VAL A 167
GLN A 147
ILE A  88
ALA A 217
 None
 1.10A 2qb4A-5muxA:
undetectable		 2qb4A-5muxA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 7 ILE A  41
GLY A  38
PHE A 432
ILE A 448
 None
 0.87A 2y7wC-5muxA:
undetectable		 2y7wC-5muxA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_B_SALB1340_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 8 LEU A 109
THR A 171
ALA A 116
ALA A 115
 None
 0.84A 3ax9B-5muxA:
undetectable		 3ax9B-5muxA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CB8_A_SAMA501_0
(PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 TYR A 339
HIS A 354
ASN A 361
ARG A 364
LEU A 346
 None
 1.45A 3cb8A-5muxA:
undetectable		 3cb8A-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 THR A 341
ILE A 321
ASP A 322
ALA A 317
ILE A 392
 None
 1.08A 3ddyA-5muxA:
undetectable		 3ddyA-5muxA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 8 ALA A 289
ALA A 292
ILE A 340
GLU A 282
 None
None
None
TLA  A 501 (-3.4A)
 0.85A 3dtuC-5muxA:
0.0
3dtuD-5muxA:
undetectable		 3dtuC-5muxA:
undetectable
3dtuD-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 10 LEU A 150
VAL A   7
ILE A   8
TRP A 194
ILE A 186
 None
 1.05A 3kz7A-5muxA:
undetectable		 3kz7A-5muxA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 MET A 270
VAL A 273
ASP A  95
ILE A 112
VAL A 136
 None
 1.25A 3p6gA-5muxA:
undetectable		 3p6gA-5muxA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 ILE A 112
ALA A 115
ALA A 116
LEU A 131
ILE A 141
 None
 1.08A 3uvvB-5muxA:
undetectable		 3uvvB-5muxA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 6 HIS A 144
ASP A 334
ASP A  95
GLU A 282
 None
None
None
TLA  A 501 (-3.4A)
 1.30A 3vywA-5muxA:
undetectable		 3vywA-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		6 / 12 LEU A 261
LEU A 265
ILE A  11
ASN A 108
GLY A 148
VAL A 149
 None
 0.90A 4an2A-5muxA:
undetectable		 4an2A-5muxA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 7 SER A  22
GLU A 145
ILE A 141
ASP A 266
 None
 1.14A 4d33B-5muxA:
undetectable		 4d33B-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 9 ALA A 217
GLY A 111
ILE A  84
GLY A  85
ILE A  88
 None
 1.13A 4eatB-5muxA:
undetectable		 4eatB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_ACTA303_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		3 / 3 TYR A 203
HIS A 163
ARG A 204
 None
TLA  A 501 (-3.9A)
TLA  A 501 (-3.9A)
 1.01A 4htfA-5muxA:
undetectable		 4htfA-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 11 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.16A 4j6cA-5muxA:
undetectable		 4j6cA-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 10 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.15A 4j6cB-5muxA:
undetectable		 4j6cB-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.11A 4j6dA-5muxA:
undetectable		 4j6dA-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.11A 4j6dB-5muxA:
undetectable		 4j6dB-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.11A 4jbtA-5muxA:
undetectable		 4jbtA-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 11 ALA A  81
ALA A  80
ALA A 114
VAL A 119
LEU A 179
 None
 1.12A 4jbtB-5muxA:
undetectable		 4jbtB-5muxA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 LEU A 261
LEU A 265
ILE A  11
ASN A 108
GLY A 148
 None
 0.86A 4lmnA-5muxA:
undetectable		 4lmnA-5muxA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 6 ILE A 365
ASP A 362
ARG A 364
VAL A 299
 None
 1.07A 4oltA-5muxA:
undetectable		 4oltA-5muxA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 LEU A 109
LEU A  34
VAL A  32
GLY A  30
ALA A  29
 None
 1.07A 4rrwC-5muxA:
undetectable		 4rrwC-5muxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 LEU A 109
LEU A  34
VAL A  32
GLY A  30
ALA A  29
 None
 1.07A 4rrzC-5muxA:
undetectable		 4rrzC-5muxA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 4 ALA A 143
VAL A 167
GLY A 224
THR A 172
 None
 1.13A 4ubeA-5muxA:
undetectable		 4ubeA-5muxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A  38
ILE A 448
GLY A  70
GLY A 110
PHE A 466
 None
 1.07A 5d4uA-5muxA:
undetectable		 5d4uA-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 GLY A  38
ILE A 448
GLY A  70
GLY A 110
PHE A 466
 None
 1.02A 5d4uB-5muxA:
undetectable		 5d4uB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 11 LEU A 150
VAL A   7
ILE A   8
TRP A 194
ALA A 176
 None
 1.09A 5d75A-5muxA:
undetectable		 5d75A-5muxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 6 ASP A  92
HIS A 104
ILE A  88
TYR A 203
 TLA  A 501 ( 4.9A)
TLA  A 501 (-4.0A)
None
None
 1.21A 5ih0A-5muxA:
undetectable		 5ih0A-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_C_FUAC1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		3 / 3 VAL A 396
HIS A 296
VAL A 299
 None
 0.46A 5jmnC-5muxA:
undetectable		 5jmnC-5muxA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		5 / 12 VAL A 409
SER A 393
ILE A 318
ALA A 317
VAL A 374
 None
 1.18A 5n0sB-5muxA:
undetectable		 5n0sB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 5 GLU A 290
THR A 287
HIS A 284
LEU A 274
 None
 1.34A 5utuH-5muxA:
undetectable		 5utuH-5muxA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 8 ILE A 146
LEU A 190
LEU A 227
ALA A 228
 None
 0.77A 5y7pE-5muxA:
undetectable		 5y7pE-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 4 ALA A 176
ALA A 175
ALA A 228
ALA A 189
 None
 0.82A 6gtqA-5muxA:
0.0
6gtqB-5muxA:
0.0		 6gtqA-5muxA:
undetectable
6gtqB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA205_0
(N-ACETYLTRANSFERASE)		 5mux 2-METHYLCITRATE
DEHYDRATASE
(Bacillus
subtilis) 		4 / 4 ALA A 228
ALA A 189
ALA A 176
ALA A 175
 None
 0.82A 6gtqA-5muxA:
0.0
6gtqB-5muxA:
0.0		 6gtqA-5muxA:
undetectable
6gtqB-5muxA:
undetectable