SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 5mw5 PROTEIN JAGGED-2
(Homo
sapiens) 		5 / 10 THR A  95
PRO A  96
LEU A  37
THR A  69
GLY A  99
 None
 1.21A 1h4oA-5mw5A:
undetectable
1h4oB-5mw5A:
undetectable		 1h4oA-5mw5A:
19.57
1h4oB-5mw5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 5mw5 PROTEIN JAGGED-2
(Homo
sapiens) 		4 / 5 ALA A 205
ASN A 173
ILE A 172
ASP A 176
 None
 1.18A 1yc2D-5mw5A:
undetectable		 1yc2D-5mw5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 5mw5 PROTEIN JAGGED-2
(Homo
sapiens) 		5 / 12 ILE A 163
THR A  95
LEU A  98
PHE A 103
LEU A 105
 None
 1.47A 2mjiA-5mw5A:
undetectable		 2mjiA-5mw5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5mw5 PROTEIN JAGGED-2
(Homo
sapiens) 		4 / 6 ILE A 132
PRO A 133
PHE A 134
PHE A 136
 None
 1.04A 4fgkA-5mw5A:
undetectable		 4fgkA-5mw5A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5mw5 PROTEIN JAGGED-2
(Homo
sapiens) 		4 / 6 ASP A  51
ASP A 152
ASN A 158
ASP A  68
 CA  A 403 (-2.1A)
CA  A 404 ( 2.0A)
None
CA  A 402 ( 2.4A)
 1.20A 4mdaA-5mw5A:
undetectable		 4mdaA-5mw5A:
20.34