SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 8 PHE A  92
ILE A  88
PHE A  86
LEU A  23
 8S9  A 302 (-4.5A)
None
None
None
 0.73A 1fslB-5mwaA:
undetectable		 1fslB-5mwaA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		4 / 7 LYS A 144
LEU A 143
LEU A  14
PHE A   8
 None
 1.01A 2dysP-5mwaA:
undetectable
2dysW-5mwaA:
undetectable		 2dysP-5mwaA:
undetectable
2dysW-5mwaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_0U9A601_1
(CHOLESTEROL
24-HYDROXYLASE)		 5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 PHE A  86
LEU A  23
VAL A  19
THR A  50
ALA A  40
 None
None
8S9  A 302 (-3.8A)
8S9  A 302 ( 4.8A)
None
 1.29A 4fiaA-5mwaA:
undetectable		 4fiaA-5mwaA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIA_A_198A602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 12 PHE A  86
LEU A  23
VAL A  19
THR A  50
ALA A  40
 None
None
8S9  A 302 (-3.8A)
8S9  A 302 ( 4.8A)
None
 1.29A 4fiaA-5mwaA:
undetectable		 4fiaA-5mwaA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFT_A_51GA204_1
(AMINOGLYCOSIDE
NUCLEOTIDYLTRANSFERA
SE (2')-IA)		 5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 9 ASP A 185
ASP A   9
LEU A 190
ASP A 184
ILE A 151
 MG  A 301 (-2.5A)
MG  A 301 (-2.4A)
None
MG  A 301 ( 4.3A)
None
 1.39A 5cftA-5mwaA:
0.0		 5cftA-5mwaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5mwa BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens) 		5 / 9 VAL A  22
LEU A  23
LEU A  60
PRO A  17
ALA A  18
 None
None
8S9  A 302 (-4.8A)
8S9  A 302 (-4.3A)
None
 1.22A 5og9A-5mwaA:
undetectable		 5og9A-5mwaA:
9.83