SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mwc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 7 TYR D 260
GLN D  73
TYR D 112
GLN D 297
 None
CR2  D  70 ( 4.9A)
CR2  D  70 ( 4.8A)
None
 1.21A 1eiiA-5mwcD:
undetectable		 1eiiA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 8 PHE D 293
GLU D 295
TYR D 112
TYR D 114
 CR2  D  70 ( 4.5A)
CR2  D  70 ( 2.9A)
CR2  D  70 ( 4.8A)
CR2  D  70 ( 4.5A)
 1.26A 2aoxA-5mwcD:
undetectable		 2aoxA-5mwcD:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		5 / 11 THR D 130
LEU D  63
SER D  51
MET D  32
ILE D  21
 None
 0.87A 2zbzA-5mwcD:
undetectable		 2zbzA-5mwcD:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		3 / 3 THR D 258
SER D 238
PHE D 262
 None
 0.85A 3d4sA-5mwcD:
undetectable		 3d4sA-5mwcD:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		3 / 3 ARG D 113
GLU D 124
PHE D  22
 None
 0.96A 4kszA-5mwcD:
undetectable		 4kszA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 8 PRO D 133
ASP D 104
SER D 254
SER D 243
 None
 1.12A 4kttA-5mwcD:
undetectable		 4kttA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		6 / 12 TYR D  74
TYR D 114
GLY D 123
GLU D  18
PHE D 293
HIS D  72
 None
CR2  D  70 ( 4.5A)
None
None
CR2  D  70 ( 4.5A)
CR2  D  70 ( 4.1A)
 1.22A 4wcxC-5mwcD:
undetectable		 4wcxC-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		5 / 12 TYR D 114
GLY D 123
GLU D  18
PRO D  40
ALA D  87
 CR2  D  70 ( 4.5A)
None
None
None
None
 1.23A 4wcxC-5mwcD:
undetectable		 4wcxC-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 7 LEU D 291
ILE D  62
LEU D 143
MET D 146
 None
None
None
CR2  D  70 ( 4.4A)
 0.98A 5fxtA-5mwcD:
undetectable		 5fxtA-5mwcD:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 5 PHE D  71
LEU D  49
GLY D  34
ILE D 121
 CR2  D  70 ( 3.5A)
None
None
None
 1.00A 5ik1A-5mwcD:
undetectable		 5ik1A-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		3 / 3 SER D  24
LEU D  49
MET D  32
 None
 0.83A 5ikrB-5mwcD:
undetectable		 5ikrB-5mwcD:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM3_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 6 SER D  24
PHE D  30
ASP D  29
HIS D  20
 None
 0.96A 5om3A-5mwcD:
undetectable
5om3B-5mwcD:
undetectable		 5om3A-5mwcD:
22.62
5om3B-5mwcD:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		6 / 12 VAL D 127
VAL D  64
LEU D  63
PHE D  30
GLY D  27
PHE D 132
 None
 1.31A 6drzA-5mwcD:
undetectable		 6drzA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 8 HIS D  66
PRO D  65
SER D 107
PHE D 102
 None
CR2  D  70 ( 4.5A)
None
None
 1.21A 6fcbA-5mwcD:
undetectable		 6fcbA-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC
(synthetic
construct) 		4 / 8 PRO D 133
ASP D 104
SER D 254
SER D 243
 None
 1.23A 6fcbA-5mwcD:
undetectable		 6fcbA-5mwcD:
undetectable