SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mwn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 189
HIS A 260
HIS A 292
LEU A  38
GLY A  37
 None
 1.30A 1d4fB-5mwnA:
undetectable		 1d4fB-5mwnA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
LEU N  29
GLY N  26
SER N  76
MET N  34
 None
 1.42A 1fdsA-5mwnN:
undetectable		 1fdsA-5mwnN:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 0.99A 1sqnA-5mwnA:
undetectable		 1sqnA-5mwnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.12A 1sqnB-5mwnA:
undetectable		 1sqnB-5mwnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 ALA A 286
GLY A 273
LEU A 305
SER A 304
LEU A 204
 None
 1.01A 1ya4A-5mwnA:
undetectable		 1ya4A-5mwnA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.19A 1zucB-5mwnA:
undetectable		 1zucB-5mwnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.01A 2w8yB-5mwnA:
undetectable		 2w8yB-5mwnA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSC_B_PQNB1773_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  49
ARG A  63
ALA A  46
LEU A  64
ALA A  61
 None
 1.45A 2wscB-5mwnA:
undetectable		 2wscB-5mwnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WSE_B_PQNB1774_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  49
ARG A  63
ALA A  46
LEU A  64
ALA A  61
 None
 1.45A 2wseB-5mwnA:
undetectable		 2wseB-5mwnA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 12 LEU A 303
LEU A 306
ASN A 307
LEU A 309
LEU A 250
 None
 1.03A 3d90A-5mwnA:
undetectable		 3d90A-5mwnA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 10 PHE A  49
ARG A  63
ALA A  46
LEU A  64
ALA A  61
 None
 1.42A 3lw5B-5mwnA:
undetectable		 3lw5B-5mwnA:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
ALA N  24
ARG N  71
VAL N  78
ALA N  97
 None
 0.91A 3qxtA-5mwnN:
18.4		 3qxtA-5mwnN:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
 None
 0.94A 3qxtA-5mwnN:
18.4		 3qxtA-5mwnN:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
ALA N  24
ARG N  71
VAL N  78
ALA N  97
 None
 0.85A 3qxvB-5mwnN:
18.2		 3qxvB-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
 None
 0.86A 3qxvB-5mwnN:
18.2		 3qxvB-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 11 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
 None
 0.78A 3qxvC-5mwnN:
18.2		 3qxvC-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
ALA N  24
ARG N  71
VAL N  78
ALA N  97
 None
 0.94A 3qxvD-5mwnN:
18.3		 3qxvD-5mwnN:
67.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5mwn LLAMA NANOBODY
RAISED AGAINST TSSK,
NBK27
(Lama
glama) 		5 / 12 VAL N   2
ALA N  24
MET N  34
VAL N  78
ALA N  97
 None
 0.95A 3qxvD-5mwnN:
18.3		 3qxvD-5mwnN:
67.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		5 / 10 LEU A 271
LEU A 276
LEU A 305
LEU A 302
LEU A 208
 None
 1.04A 4odoC-5mwnA:
undetectable		 4odoC-5mwnA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 157
HIS A 156
ARG A  94
 None
 1.07A 4qyqA-5mwnA:
undetectable		 4qyqA-5mwnA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 157
HIS A 156
ARG A  94
 None
 1.10A 4qyqB-5mwnA:
undetectable		 4qyqB-5mwnA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5mwn TYPE VI SECRETION
PROTEIN
(Escherichia
coli) 		4 / 6 LEU A  54
PRO A 182
PHE A 184
GLU A 296
 None
 0.91A 5b8iA-5mwnA:
undetectable		 5b8iA-5mwnA:
22.34