SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A 142
ARG A 143
ILE A 146
 None
 0.59A 1uobA-5mwrA:
undetectable		 1uobA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		5 / 12 ILE A  87
ILE A 159
SER A 155
ALA A 162
PHE A  97
 None
None
PTR  A 133 ( 3.4A)
None
None
 1.25A 2ejtA-5mwrA:
undetectable		 2ejtA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		4 / 8 SER A 175
SER A 173
ASN A 174
GLY A 166
 None
 1.00A 4af0A-5mwrA:
undetectable		 4af0A-5mwrA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		5 / 11 LEU A 193
VAL A 157
ILE A 161
MET A  94
LEU A 165
 None
 1.49A 4lhmA-5mwrA:
undetectable		 4lhmA-5mwrA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 193
LEU A 137
ARG A  86
 None
PTR  A 133 ( 3.6A)
PTR  A 133 ( 4.3A)
 0.60A 6fgcA-5mwrA:
undetectable		 6fgcA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR
(Sulfolobus
acidocaldarius) 		3 / 3 LEU A 193
LEU A 137
ARG A  86
 None
PTR  A 133 ( 3.6A)
PTR  A 133 ( 4.3A)
 0.65A 6fgdA-5mwrA:
undetectable		 6fgdA-5mwrA:
undetectable