SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mx0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 6 LEU A 207
LEU A 235
LEU A 202
LEU A 178
 None
 0.88A 1errA-5mx0A:
undetectable		 1errA-5mx0A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 8 SER A 329
LEU A 285
LEU A 300
LEU A 298
 None
 1.01A 2bfpA-5mx0A:
undetectable		 2bfpA-5mx0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 8 SER A 329
LEU A 285
LEU A 300
LEU A 298
 None
 1.03A 2bfpD-5mx0A:
undetectable		 2bfpD-5mx0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		5 / 12 LEU A 160
VAL A 110
ILE A 120
LEU A 100
PHE A 125
 None
 1.18A 3datA-5mx0A:
undetectable		 3datA-5mx0A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 8 GLU A 247
LEU A 271
TYR A 250
TYR A 272
 None
 0.99A 3i45A-5mx0A:
undetectable		 3i45A-5mx0A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		5 / 10 LEU A 160
VAL A 110
ILE A 120
LEU A 100
PHE A 125
 None
 1.07A 3jw5B-5mx0A:
undetectable		 3jw5B-5mx0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		5 / 11 ALA A 359
ILE A 376
ILE A 330
ILE A 325
ILE A 355
 None
 1.13A 3s53B-5mx0A:
undetectable		 3s53B-5mx0A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 5 VAL A 273
ARG A 274
MET A 251
GLU A 252
 None
 1.22A 4hojA-5mx0A:
undetectable		 4hojA-5mx0A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 6 LEU A 285
ASN A 282
LEU A 300
ILE A 325
 None
 1.16A 4okxA-5mx0A:
undetectable		 4okxA-5mx0A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_A_VORA590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 7 SER A 332
ILE A 330
LEU A 368
PHE A 333
 None
 1.03A 4uymA-5mx0A:
undetectable		 4uymA-5mx0A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		5 / 12 ASP A 240
PRO A 243
ARG A 220
GLY A 221
LEU A 222
 None
 1.42A 5m50B-5mx0A:
undetectable		 5m50B-5mx0A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		3 / 3 HIS A 164
ASP A 184
HIS A 185
 None
 0.95A 5n1tW-5mx0A:
undetectable		 5n1tW-5mx0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5mx0 FIBROMODULIN
(Homo
sapiens) 		4 / 6 LEU A 196
ALA A 195
LEU A 228
ASN A 233
 None
 0.97A 6f88B-5mx0A:
undetectable		 6f88B-5mx0A:
11.36