SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mx5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1
(Mus
musculus) 		4 / 5 LEU A 167
GLN A 127
THR A 125
LEU A  40
 None
 1.18A 3ce6D-5mx5A:
undetectable		 3ce6D-5mx5A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 2
(Mus
musculus) 		4 / 7 ARG B 204
ASP B 183
ALA B 184
TYR B 197
 None
 1.18A 4zz8A-5mx5B:
undetectable		 4zz8A-5mx5B:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ONL_A_010A302_0
(YNDL)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1
(Mus
musculus) 		4 / 5 GLU A 218
LYS A 166
GLU A 211
PHE A 170
 None
 1.25A 5onlA-5mx5A:
undetectable		 5onlA-5mx5A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1
PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 2
(Mus
musculus) 		5 / 12 VAL B  16
ASP B  15
LEU B 130
SER A  38
GLN B 136
 None
 1.21A 5syfB-5mx5B:
undetectable		 5syfB-5mx5B:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 2
(Mus
musculus) 		5 / 12 VAL B 185
VAL B 201
ASP B 205
THR B 173
LEU B 114
 None
 1.09A 5x24A-5mx5B:
undetectable		 5x24A-5mx5B:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB804_0
(UNCHARACTERIZED
PROTEIN)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1
(Mus
musculus) 		4 / 4 HIS A 202
VAL A 104
LEU A  61
ALA A  59
 None
 1.39A 6d8pB-5mx5A:
undetectable		 6d8pB-5mx5A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HRJ_A_010A302_0
(YNDL)		 5mx5 PROTEASOME ACTIVATOR
COMPLEX SUBUNIT 1
(Mus
musculus) 		4 / 5 GLU A 218
LYS A 166
GLU A 211
PHE A 170
 None
 1.27A 6hrjA-5mx5A:
undetectable		 6hrjA-5mx5A:
18.96