SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mx9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		4 / 8 TYR A 399
GLU A 246
HIS A 514
SER A 288
 None
ZN  A 602 (-1.9A)
None
None
 1.29A 1nx9A-5mx9A:
undetectable		 1nx9A-5mx9A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		3 / 3 GLU A 453
ASN A 499
TRP A 497
 None
 1.25A 1r15C-5mx9A:
undetectable		 1r15C-5mx9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		3 / 3 GLU A 453
ASN A 499
TRP A 497
 None
 1.26A 1r15E-5mx9A:
undetectable		 1r15E-5mx9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		3 / 3 GLU A 453
ASN A 499
TRP A 497
 None
 1.26A 1r15F-5mx9A:
undetectable		 1r15F-5mx9A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		3 / 3 TYR A 431
ASP A 251
HIS A 466
 None
None
ZN  A 602 (-3.1A)
 0.91A 3e23A-5mx9A:
2.1		 3e23A-5mx9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		4 / 5 GLN A 298
THR A 285
HIS A 478
HIS A 514
 None
ZN  A 602 (-2.6A)
ZN  A 601 (-3.1A)
None
 1.37A 3g1uC-5mx9A:
undetectable		 3g1uC-5mx9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		5 / 12 LEU A 316
GLY A 320
ARG A 235
PHE A 525
MET A 388
 None
 1.22A 3h52C-5mx9A:
undetectable		 3h52C-5mx9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG801_0
(GLUTAMATE RECEPTOR 2)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		3 / 3 PRO A 290
SER A 332
ASN A 311
 None
GOL  A 604 (-1.9A)
None
 0.93A 3lslG-5mx9A:
0.5		 3lslG-5mx9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		4 / 5 GLY A 372
THR A 451
VAL A 377
ASP A 375
 None
 1.06A 4eohA-5mx9A:
undetectable		 4eohA-5mx9A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		6 / 6 GLY A 282
THR A 283
SER A 284
TYR A 287
GLY A 479
ASN A 482
 None
 0.25A 5k4pA-5mx9A:
56.8		 5k4pA-5mx9A:
82.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		5 / 10 TYR A 403
ILE A 442
ILE A 446
LEU A 449
ASN A 328
 None
 1.44A 5vkqA-5mx9A:
undetectable
5vkqD-5mx9A:
undetectable		 5vkqA-5mx9A:
11.57
5vkqD-5mx9A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		5 / 10 ASN A 328
TYR A 403
ILE A 442
ILE A 446
LEU A 449
 None
 1.40A 5vkqA-5mx9A:
undetectable
5vkqB-5mx9A:
undetectable		 5vkqA-5mx9A:
11.57
5vkqB-5mx9A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		5 / 10 ASN A 328
TYR A 403
ILE A 442
ILE A 446
LEU A 449
 None
 1.44A 5vkqC-5mx9A:
undetectable
5vkqD-5mx9A:
undetectable		 5vkqC-5mx9A:
11.57
5vkqD-5mx9A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_1
(ADENOSYLHOMOCYSTEINA
SE)		 5mx9 PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-2
(Escherichia
coli) 		5 / 12 LEU A 435
ASP A 432
LEU A 470
GLY A 467
PHE A 263
 None
 1.38A 6aphA-5mx9A:
undetectable		 6aphA-5mx9A:
21.61