SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mxp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5mxp -
(-) 		5 / 12 LEU A  46
GLU A 186
ASP A 278
HIS A 273
LEU A 174
 None
None
None
ACT  A 401 ( 4.3A)
None
 1.42A 1d4fB-5mxpA:
5.5		 1d4fB-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5mxp -
(-) 		4 / 5 LEU A  35
GLY A 111
ILE A 122
ILE A  99
 None
 0.74A 2q9rA-5mxpA:
undetectable		 2q9rA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5mxp -
(-) 		5 / 10 ILE A 122
ILE A 101
GLY A 107
PHE A 109
LEU A 230
 None
 1.24A 3elzB-5mxpA:
undetectable		 3elzB-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBW_A_BEZA501_0
(HALOALKANE
DEHALOGENASE)		 5mxp -
(-) 		7 / 9 ASP A 105
TRP A 106
PHE A 149
PHE A 169
LEU A 210
HIS A 273
TYR A 274
 ACT  A 401 (-2.5A)
ACT  A 401 ( 4.9A)
ACT  A 401 (-4.6A)
ACT  A 401 (-4.5A)
ACT  A 401 ( 4.9A)
ACT  A 401 ( 4.3A)
None
 0.94A 3fbwA-5mxpA:
45.2		 3fbwA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 5mxp -
(-) 		5 / 10 ILE A 122
ALA A 115
LEU A  37
THR A  42
ILE A  80
 None
 1.05A 3prsA-5mxpA:
undetectable		 3prsA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5mxp -
(-) 		5 / 12 PHE A 169
THR A  42
HIS A 104
LEU A 187
HIS A 273
 ACT  A 401 (-4.5A)
None
None
None
ACT  A 401 ( 4.3A)
 1.18A 3sp9A-5mxpA:
undetectable		 3sp9A-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 5mxp -
(-) 		5 / 12 PHE A 169
THR A  42
HIS A 104
LEU A 187
HIS A 273
 ACT  A 401 (-4.5A)
None
None
None
ACT  A 401 ( 4.3A)
 1.21A 3sp9B-5mxpA:
undetectable		 3sp9B-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 5mxp -
(-) 		6 / 8 ASP A 105
TRP A 106
PHE A 169
LEU A 210
HIS A 273
TYR A 274
 ACT  A 401 (-2.5A)
ACT  A 401 ( 4.9A)
ACT  A 401 (-4.5A)
ACT  A 401 ( 4.9A)
ACT  A 401 ( 4.3A)
None
 0.46A 4f5zA-5mxpA:
45.3		 4f5zA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 5mxp -
(-) 		5 / 11 SER A  21
ILE A  66
LEU A  37
ASP A  88
GLY A  89
 NA  A 403 (-2.6A)
None
None
None
None
 1.28A 4fogA-5mxpA:
undetectable		 4fogA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 5mxp -
(-) 		5 / 11 SER A  21
ILE A  66
LEU A  37
ASP A  88
GLY A  89
 NA  A 403 (-2.6A)
None
None
None
None
 1.31A 4fogC-5mxpA:
undetectable		 4fogC-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 5mxp -
(-) 		4 / 6 ILE A  84
ASP A  81
ARG A  85
VAL A  18
 None
 1.07A 4oltA-5mxpA:
undetectable		 4oltA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB303_1
(CHITOSANASE)		 5mxp -
(-) 		4 / 6 ILE A  84
ASP A  81
ARG A  85
VAL A  18
 None
 1.08A 4oltB-5mxpA:
undetectable		 4oltB-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 5mxp -
(-) 		5 / 12 ALA A 225
TYR A 226
LEU A 210
ILE A 173
PHE A 141
 None
None
ACT  A 401 ( 4.9A)
None
None
 1.15A 5fsaA-5mxpA:
undetectable		 5fsaA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5mxp -
(-) 		3 / 3 ILE A 135
PRO A 136
ILE A 212
 None
 0.43A 5hw8F-5mxpA:
undetectable		 5hw8F-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5mxp -
(-) 		4 / 8 ALA A 250
VAL A 253
ILE A 275
VAL A 268
 None
 0.86A 5nujA-5mxpA:
undetectable		 5nujA-5mxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 5mxp -
(-) 		5 / 9 LEU A 210
LEU A 247
ILE A 173
LEU A 152
MET A 177
 ACT  A 401 ( 4.9A)
None
None
None
None
 1.36A 5og9A-5mxpA:
undetectable		 5og9A-5mxpA:
undetectable