SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5my0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 7 ILE B 834
TYR B  87
PHE B  65
PHE B 148
 None
 1.26A 1e71M-5my0B:
undetectable		 1e71M-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_A_ESTA600_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 9 ALA B 599
GLU B 598
LEU B 594
ARG B 706
ILE B 577
 None
 1.50A 1ereA-5my0B:
undetectable		 1ereA-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 9 ALA B 599
GLU B 598
LEU B 594
ARG B 706
ILE B 577
 None
 1.49A 1ereB-5my0B:
undetectable		 1ereB-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_C_ESTC600_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 9 ALA B 599
GLU B 598
LEU B 594
ARG B 706
ILE B 577
 None
 1.50A 1ereC-5my0B:
undetectable		 1ereC-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_D_ESTD600_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 9 ALA B 599
GLU B 598
LEU B 594
ARG B 706
ILE B 577
 None
 1.49A 1ereD-5my0B:
undetectable		 1ereD-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 ASP B  35
ASP B  37
LYS B  53
 None
 0.96A 1lqtB-5my0B:
undetectable		 1lqtB-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 ASP B  35
ASP B  37
LYS B  53
 None
 0.95A 1lquB-5my0B:
undetectable		 1lquB-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 VAL B 229
ILE B 390
GLY B 337
ALA B 339
THR B 325
 None
 1.00A 1r9oA-5my0B:
undetectable		 1r9oA-5my0B:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 6 LEU B 232
ALA B 182
LEU B 184
SER B 154
 None
 0.94A 1tz8C-5my0B:
undetectable
1tz8D-5my0B:
undetectable		 1tz8C-5my0B:
20.16
1tz8D-5my0B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 ASN B 189
TYR B 222
SER B 336
 None
 0.71A 2gvcB-5my0B:
undetectable		 2gvcB-5my0B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 ASN B 189
TYR B 222
SER B 336
 None
 0.65A 2gvcE-5my0B:
undetectable		 2gvcE-5my0B:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
 None
 1.25A 2j7xA-5my0B:
undetectable		 2j7xA-5my0B:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2N27_A_4DYA205_1
(CALMODULIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 MET B  32
MET B 329
LEU B 168
VAL B 231
MET B   9
 None
 1.48A 2n27A-5my0B:
undetectable		 2n27A-5my0B:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 7 ILE B 290
GLY B 389
LEU B 276
PHE B 393
 None
 0.96A 2vctD-5my0B:
undetectable		 2vctD-5my0B:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 THR B 342
VAL B  85
LEU B 184
VAL B 185
ALA B 335
 None
 1.16A 2zbzA-5my0B:
undetectable		 2zbzA-5my0B:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 SER B  63
GLU B  84
ASP B 837
 None
 0.83A 2zthA-5my0B:
2.0		 2zthA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 5 VAL B 527
GLN B 596
PHE B 553
ARG B 522
 None
 1.30A 3bjwE-5my0B:
undetectable		 3bjwE-5my0B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 VAL B   5
LEU B 233
ILE B  90
SER B  10
LYS B  12
 None
 1.10A 3bjwB-5my0B:
undetectable		 3bjwB-5my0B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 5 VAL B 532
VAL B 527
GLN B 596
PHE B 553
ARG B 522
 None
 1.50A 3bjwB-5my0B:
undetectable		 3bjwB-5my0B:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 157
ALA B 174
ALA B 249
VAL B 402
ILE B 155
 None
 1.09A 3czhB-5my0B:
undetectable		 3czhB-5my0B:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 PHE B 359
PRO B  48
SER B 218
CYH B 212
HIS B 358
 None
 1.18A 3e23A-5my0B:
undetectable		 3e23A-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 LEU B 567
ALA B 590
ILE B 561
GLY B 583
ILE B 564
 None
 0.91A 3ebzA-5my0B:
undetectable		 3ebzA-5my0B:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 GLY B 571
GLY B 807
THR B 806
LEU B 805
VAL B 485
 None
 1.02A 3eluA-5my0B:
undetectable		 3eluA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 GLY B 571
GLY B 807
THR B 806
LEU B 805
VAL B 485
 None
 0.99A 3embA-5my0B:
undetectable		 3embA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ALA B 426
ASN B 455
HIS B 425
PHE B 816
LEU B 797
 None
 1.21A 3hkuA-5my0B:
undetectable		 3hkuA-5my0B:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
 None
 1.26A 3hm1B-5my0B:
undetectable		 3hm1B-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 10 LEU B 190
ILE B 188
SER B 164
SER B 336
GLY B 187
 None
 1.29A 3ik6B-5my0B:
undetectable
3ik6E-5my0B:
undetectable		 3ik6B-5my0B:
13.95
3ik6E-5my0B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 10 LEU B 190
ILE B 188
SER B 164
SER B 336
GLY B 187
 None
 1.23A 3iluB-5my0B:
undetectable
3iluE-5my0B:
undetectable		 3iluB-5my0B:
13.95
3iluE-5my0B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 ILE B 188
SER B 164
SER B 336
GLY B 187
LEU B 190
 None
 1.31A 3iluB-5my0B:
undetectable
3iluE-5my0B:
undetectable		 3iluB-5my0B:
13.95
3iluE-5my0B:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID800_0
(GLUTAMATE RECEPTOR 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 7 SER B 114
MET B 139
LEU B  79
ASP B  76
 None
 1.45A 3lslA-5my0B:
undetectable
3lslD-5my0B:
undetectable		 3lslA-5my0B:
undetectable
3lslD-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 7 ILE B 761
PHE B 516
MET B 511
GLY B 507
 None
 1.23A 3sj0X-5my0B:
undetectable		 3sj0X-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		6 / 10 ALA B 590
ASP B 591
GLY B 579
ILE B 495
LEU B 563
ILE B 564
 None
 1.13A 3ttpA-5my0B:
undetectable		 3ttpA-5my0B:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		6 / 10 ALA B 590
ASP B 591
GLY B 579
ILE B 495
LEU B 563
ILE B 564
 None
 1.11A 3ttpB-5my0B:
undetectable		 3ttpB-5my0B:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 MET B   9
GLY B  93
ASP B  92
SER B 831
LEU B 346
 None
 1.21A 3v8vB-5my0B:
2.5		 3v8vB-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 TYR B 277
ILE B 246
VAL B 344
LEU B 348
VAL B 383
 None
 1.00A 3w68D-5my0B:
undetectable		 3w68D-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 GLN B 259
ASP B 254
GLN B 269
 None
 0.88A 4aztA-5my0B:
undetectable		 4aztA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ALA B 167
ASN B 170
ARG B 176
ILE B 246
VAL B 402
 None
 1.26A 4azwA-5my0B:
undetectable		 4azwA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 VAL B 107
ALA B 183
LEU B  82
VAL B 109
THR B 105
 None
 1.36A 4eilA-5my0B:
undetectable		 4eilA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 VAL B 107
ALA B 183
LEU B  82
VAL B 109
THR B 105
 None
 1.35A 4eilC-5my0B:
undetectable		 4eilC-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
 None
 1.26A 4j26A-5my0B:
undetectable		 4j26A-5my0B:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 VAL B 107
ALA B 183
LEU B  82
VAL B 109
THR B 105
 None
 1.37A 4kyaA-5my0B:
undetectable		 4kyaA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_C_FOLC703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 10 VAL B 107
ALA B 183
LEU B  82
VAL B 109
THR B 105
 None
 1.38A 4kyaC-5my0B:
undetectable		 4kyaC-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 VAL B 107
ALA B 183
LEU B  82
VAL B 109
THR B 105
 None
 1.37A 4kyaE-5my0B:
undetectable		 4kyaE-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 VAL B 107
ALA B 183
LEU B  82
VAL B 109
THR B 105
 None
 1.40A 4kyaG-5my0B:
undetectable		 4kyaG-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ALA B 141
GLY B 110
GLY B 186
LEU B 338
ALA B 156
 None
 1.05A 4lg1C-5my0B:
undetectable		 4lg1C-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		7 / 12 ALA B 160
CYH B 161
PHE B 200
HIS B 293
THR B 295
HIS B 331
GLY B 394
 None
 0.56A 4ls7A-5my0B:
47.4		 4ls7A-5my0B:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		7 / 12 CYH B 161
PHE B 200
HIS B 293
THR B 295
HIS B 331
GLY B 394
PHE B 395
 None
 1.00A 4ls7A-5my0B:
47.4		 4ls7A-5my0B:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		7 / 12 ALA B 160
CYH B 161
PHE B 200
HIS B 293
THR B 295
HIS B 331
GLY B 394
 None
 0.55A 4ls7A-5my0B:
47.4
4ls7B-5my0B:
47.3		 4ls7A-5my0B:
11.51
4ls7B-5my0B:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		7 / 12 CYH B 161
PHE B 200
HIS B 293
THR B 295
HIS B 331
GLY B 394
PHE B 395
 None
 1.02A 4ls7A-5my0B:
47.4
4ls7B-5my0B:
47.3		 4ls7A-5my0B:
11.51
4ls7B-5my0B:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_B_MXMB606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 VAL B 485
ARG B 468
VAL B 757
LEU B 492
LEU B 805
 None
 1.01A 4m11B-5my0B:
undetectable		 4m11B-5my0B:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 5 GLY B 428
SER B 427
ALA B 426
PHE B 467
 None
 0.99A 4m93B-5my0B:
undetectable
4m93C-5my0B:
undetectable		 4m93B-5my0B:
undetectable
4m93C-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 7 ASP B 301
LYS B 298
SER B 207
ASP B 216
 None
 1.33A 4ndnC-5my0B:
undetectable		 4ndnC-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 HIS B 401
LEU B 168
VAL B 231
MET B   9
TYR B 277
 None
 1.37A 4o8fB-5my0B:
1.2		 4o8fB-5my0B:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ALA B 171
GLN B 169
THR B 253
THR B 251
LEU B 157
 None
 1.31A 4qzuA-5my0B:
undetectable		 4qzuA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 9 ARG B  80
VAL B 844
LEU B  83
LEU B 190
ILE B 188
 None
 1.33A 4ubsA-5my0B:
undetectable		 4ubsA-5my0B:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_D_ADND303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 10 LEU B 454
GLY B 441
ASP B 447
SER B 445
ILE B 830
 None
 1.11A 4xj7C-5my0B:
undetectable
4xj7D-5my0B:
undetectable		 4xj7C-5my0B:
16.02
4xj7D-5my0B:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 ALA B 622
GLY B 624
VAL B 770
LEU B 749
LEU B 767
 None
 1.12A 4zmeA-5my0B:
undetectable		 4zmeA-5my0B:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 338
ALA B 230
LEU B 184
LEU B 233
LEU B  82
 None
 1.17A 4zn7A-5my0B:
undetectable		 4zn7A-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ALA B 335
GLY B 187
SER B 164
LEU B  83
GLU B  84
 None
 1.06A 5c0oH-5my0B:
undetectable		 5c0oH-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 11 LEU B 191
MET B 201
LEU B 206
GLY B  46
LEU B  44
 None
 1.26A 5dxgB-5my0B:
undetectable		 5dxgB-5my0B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 165
LEU B 341
ALA B 244
ILE B 246
ILE B   6
 None
 1.19A 5eypB-5my0B:
undetectable		 5eypB-5my0B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 ARG B 224
ASN B 189
ASP B  76
 None
 0.86A 5gwxA-5my0B:
undetectable		 5gwxA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ALA B 182
PHE B 148
ILE B  90
SER B  86
PHE B 150
 None
 1.34A 5hgcA-5my0B:
undetectable		 5hgcA-5my0B:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 556
LEU B 566
LEU B 538
GLY B 507
ILE B 520
 None
 1.35A 5j7wC-5my0B:
undetectable		 5j7wC-5my0B:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 THR B  74
SER B 131
TYR B 130
 None
 0.79A 5jsdA-5my0B:
undetectable		 5jsdA-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 THR B  74
SER B 131
TYR B 130
 None
 0.79A 5jsdB-5my0B:
undetectable		 5jsdB-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 THR B  74
SER B 131
TYR B 130
 None
 0.79A 5jsdC-5my0B:
undetectable		 5jsdC-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 THR B  74
SER B 131
TYR B 130
 None
 0.77A 5jseA-5my0B:
undetectable		 5jseA-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 THR B  74
SER B 131
TYR B 130
 None
 0.77A 5jseB-5my0B:
undetectable		 5jseB-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		3 / 3 THR B  74
SER B 131
TYR B 130
 None
 0.78A 5jseC-5my0B:
undetectable		 5jseC-5my0B:
7.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_2
(TUBULIN BETA-2B
CHAIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 165
LEU B 341
ALA B 244
ILE B 246
ILE B   6
 None
 1.15A 5nm5B-5my0B:
undetectable		 5nm5B-5my0B:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 10 ALA B   7
LEU B 232
VAL B 231
VAL B   4
ILE B 175
 None
 1.13A 5v02B-5my0B:
undetectable
5v02R-5my0B:
undetectable		 5v02B-5my0B:
undetectable
5v02R-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 GLU B 291
GLY B 294
LEU B 276
GLY B 389
ILE B 390
 None
 1.21A 5vooA-5my0B:
undetectable		 5vooA-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 GLU B 291
GLY B 294
LEU B 276
GLY B 389
ILE B 390
 None
 1.19A 5vooC-5my0B:
undetectable		 5vooC-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_0
(SERUM ALBUMIN)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 ILE B 752
VAL B 810
ALA B 756
LEU B 800
LEU B 563
 None
 1.05A 6a7pB-5my0B:
undetectable		 6a7pB-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 8 ASP B  92
SER B 831
TYR B 243
GLY B 351
 None
 0.88A 6giqL-5my0B:
undetectable
6giqP-5my0B:
undetectable
6giqT-5my0B:
undetectable		 6giqL-5my0B:
undetectable
6giqP-5my0B:
undetectable
6giqT-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		4 / 6 LEU B 615
VAL B 585
PHE B 686
GLY B 618
 None
 0.98A 6hd4B-5my0B:
undetectable		 6hd4B-5my0B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_D_FOZD403_0
(THYMIDYLATE SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 556
LEU B 566
LEU B 538
GLY B 507
ILE B 520
 None
 1.40A 6qxsD-5my0B:
undetectable		 6qxsD-5my0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5my0 FATTY ACID SYNTHASE
(Mus
musculus) 		5 / 12 LEU B 556
LEU B 566
LEU B 538
GLY B 507
ILE B 520
 None
 1.42A 6qyaB-5my0B:
undetectable		 6qyaB-5my0B:
undetectable