SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5myb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 8 SER A 721
ASN A 722
ASP A 711
THR A 671
 None
 1.07A 1ig3A-5mybA:
undetectable
1ig3B-5mybA:
undetectable		 1ig3A-5mybA:
20.85
1ig3B-5mybA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 601
LEU A 559
SER A 555
LEU A 634
THR A 562
 NAG  A 801 ( 4.0A)
None
None
None
NAG  A 801 (-4.3A)
 1.34A 1kw0A-5mybA:
undetectable		 1kw0A-5mybA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		3 / 3 ARG A 580
GLU A 579
GLN A 589
 None
 0.85A 2p16A-5mybA:
undetectable		 2p16A-5mybA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 7 ASP A 587
GLN A 588
GLN A 610
GLU A 609
 None
 1.08A 3l2vA-5mybA:
undetectable		 3l2vA-5mybA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 4 GLU A 643
PRO A 642
ILE A 661
LEU A 662
 None
 0.90A 5m45A-5mybA:
undetectable		 5m45A-5mybA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 4 GLU A 643
PRO A 642
ILE A 661
LEU A 662
 None
 0.88A 5m45D-5mybA:
undetectable		 5m45D-5mybA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 4 GLU A 643
PRO A 642
ILE A 661
LEU A 662
 None
 0.89A 5m45G-5mybA:
undetectable		 5m45G-5mybA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 4 GLU A 643
PRO A 642
ILE A 661
LEU A 662
 None
 0.94A 5m45J-5mybA:
undetectable		 5m45J-5mybA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens) 		4 / 4 THR A 706
VAL A 730
PRO A 733
THR A 731
 None
 1.46A 5mthA-5mybA:
5.2
5mthH-5mybA:
undetectable		 5mthA-5mybA:
20.71
5mthH-5mybA:
20.71