SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5myv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 1jffB-5myvA:
undetectable		 1jffB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 ALA A 119
LYS A 121
GLU A 136
LEU A 140
LEU A 215
HIS A 223
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
 0.75A 1uwhB-5myvA:
19.7		 1uwhB-5myvA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 2hxfB-5myvA:
undetectable		 2hxfB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 2hxhB-5myvA:
undetectable		 2hxhB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 2p4nB-5myvA:
undetectable		 2p4nB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 2wbeB-5myvA:
undetectable		 2wbeB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		8 / 12 LEU A  98
ALA A 119
LYS A 121
GLU A 136
VAL A 157
GLY A 181
LEU A 232
ALA A 540
 W4A  A 716 (-4.1A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 ( 4.5A)
 1.03A 2zvaA-5myvA:
22.5		 2zvaA-5myvA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 212
TRP A 547
TYR A 214
 None
 0.97A 3aicA-5myvA:
undetectable		 3aicA-5myvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 212
TRP A 547
TYR A 214
 None
 0.97A 3aicB-5myvA:
undetectable		 3aicB-5myvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 212
TRP A 547
TYR A 214
 None
 0.97A 3aicE-5myvA:
undetectable		 3aicE-5myvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 212
TRP A 547
TYR A 214
 None
 0.96A 3aicF-5myvA:
undetectable		 3aicF-5myvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 212
TRP A 547
TYR A 214
 None
 0.98A 3aicG-5myvA:
undetectable		 3aicG-5myvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 LEU A 212
TRP A 547
TYR A 214
 None
 0.96A 3aicH-5myvA:
undetectable		 3aicH-5myvA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 3dcoB-5myvA:
undetectable		 3dcoB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 TYR A 630
GLY A 571
SER A 573
SER A 563
TRP A 579
 None
 1.28A 3dlcA-5myvA:
undetectable		 3dlcA-5myvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.17A 3edlB-5myvA:
undetectable		 3edlB-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		9 / 12 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
VAL A 157
GLY A 181
LEU A 232
ALA A 540
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 ( 4.5A)
 1.10A 3g5dB-5myvA:
21.4		 3g5dB-5myvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 VAL A 106
ALA A 119
GLU A 136
LEU A 139
LEU A 140
HIS A 223
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
None
 0.99A 3gp0A-5myvA:
20.9		 3gp0A-5myvA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 6 VAL A 156
ILE A 221
HIS A 223
ILE A 539
 None
 0.33A 3hegA-5myvA:
19.7		 3hegA-5myvA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 GLU A 136
VAL A 157
HIS A 223
LEU A 232
ALA A 540
 DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
None
DMS  A 717 ( 4.5A)
 0.55A 3ik3A-5myvA:
19.9		 3ik3A-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 119
GLU A 136
VAL A 157
HIS A 223
ALA A 540
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
DMS  A 717 ( 4.5A)
 0.67A 3ik3B-5myvA:
19.8		 3ik3B-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 GLU A 136
VAL A 157
HIS A 223
LEU A 232
ALA A 540
 DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
None
DMS  A 717 ( 4.5A)
 0.53A 3ik3B-5myvA:
19.8		 3ik3B-5myvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 647
HIS A 612
LEU A 641
THR A 645
GLY A 600
 None
 1.14A 3iz0B-5myvA:
undetectable		 3iz0B-5myvA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		3 / 3 SER A 599
SER A 604
HIS A 612
 SO4  A 705 (-3.0A)
None
None
 0.62A 3mzeA-5myvA:
undetectable		 3mzeA-5myvA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		9 / 12 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
VAL A 157
GLY A 181
LEU A 232
ALA A 540
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 ( 4.5A)
 1.05A 3qlgA-5myvA:
20.8		 3qlgA-5myvA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		8 / 12 VAL A 106
ALA A 119
GLU A 136
LEU A 140
PHE A 177
LEU A 215
HIS A 223
ALA A 540
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
DMS  A 717 ( 3.9A)
None
None
DMS  A 717 ( 4.5A)
 0.64A 3rgfA-5myvA:
21.1		 3rgfA-5myvA:
26.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 5 LYS A 121
VAL A 157
LEU A 232
ASP A 541
 SO4  A 702 (-3.3A)
DMS  A 717 (-4.3A)
None
DMS  A 717 (-4.3A)
 0.97A 3wzdA-5myvA:
19.6		 3wzdA-5myvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 8 VAL A 156
VAL A 157
LEU A 232
ILE A 539
 None
DMS  A 717 (-4.3A)
None
None
 0.54A 3wzeA-5myvA:
19.9		 3wzeA-5myvA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
LYS A 121
GLU A 136
LEU A 215
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.79A 3zosA-5myvA:
12.7		 3zosA-5myvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
LYS A 121
GLU A 136
LEU A 215
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.83A 3zosB-5myvA:
12.7		 3zosB-5myvA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A83_A_DXCA1160_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 PRO A 526
LEU A 527
ILE A 188
TYR A 193
MET A 584
 None
 1.23A 4a83A-5myvA:
undetectable		 4a83A-5myvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 LEU A 140
ASP A 225
LYS A 227
ASN A 230
ASP A 541
GLY A 543
 None
None
None
None
DMS  A 717 (-4.3A)
None
 1.39A 4an2A-5myvA:
20.2		 4an2A-5myvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
LYS A 121
GLU A 136
LEU A 140
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.88A 4c8bA-5myvA:
19.9		 4c8bA-5myvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ALA A 119
LYS A 121
GLU A 136
LEU A 140
HIS A 223
LEU A 232
ALA A 540
 W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
None
None
None
DMS  A 717 ( 4.5A)
 0.85A 4c8bB-5myvA:
19.9		 4c8bB-5myvA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 SER A 146
CYH A 219
TYR A 214
GLY A 543
LEU A 542
 None
None
None
None
DMS  A 717 (-4.0A)
 1.13A 4j7xB-5myvA:
undetectable		 4j7xB-5myvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KS8_A_B49A701_1
(SERINE/THREONINE-PRO
TEIN KINASE PAK 6)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 10 ALA A 119
VAL A 157
LEU A 180
GLY A 181
LEU A 232
ASP A 541
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.3A)
W4A  A 716 (-4.3A)
W4A  A 716 (-3.8A)
None
DMS  A 717 (-4.3A)
 0.99A 4ks8A-5myvA:
23.5		 4ks8A-5myvA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 119
GLU A 136
LEU A 215
HIS A 223
ALA A 540
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
DMS  A 717 ( 4.5A)
 0.71A 4v01A-5myvA:
19.2		 4v01A-5myvA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 ALA A 119
GLU A 136
LEU A 215
HIS A 223
ALA A 540
 W4A  A 716 ( 3.9A)
DMS  A 717 (-4.0A)
None
None
DMS  A 717 ( 4.5A)
 0.67A 4v01B-5myvA:
19.6		 4v01B-5myvA:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A  99
VAL A 106
ALA A 119
VAL A 157
PHE A 177
LEU A 232
 W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.3A)
DMS  A 717 ( 3.9A)
None
 0.74A 5l2iA-5myvA:
14.6		 5l2iA-5myvA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 GLY A  99
VAL A 106
ALA A 119
VAL A 157
PHE A 177
LEU A 232
 W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 (-4.3A)
DMS  A 717 ( 3.9A)
None
 0.94A 5l2tA-5myvA:
14.5		 5l2tA-5myvA:
26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		5 / 12 LEU A 232
SER A 104
VAL A 106
GLY A  99
GLY A 101
 None
SO4  A 702 (-2.7A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 4.0A)
SO4  A 702 (-3.3A)
 1.24A 5nnaA-5myvA:
undetectable		 5nnaA-5myvA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		10 / 12 ARG A  96
LEU A  98
GLY A  99
VAL A 106
ALA A 119
PHE A 177
GLY A 181
VAL A 235
TYR A 239
ALA A 540
 None
W4A  A 716 (-4.1A)
W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 ( 3.9A)
W4A  A 716 (-3.8A)
W4A  A 716 ( 4.9A)
W4A  A 716 (-4.8A)
DMS  A 717 ( 4.5A)
 0.46A 5xv7A-5myvA:
49.0		 5xv7A-5myvA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 ARG A  96
PHE A 177
GLY A 181
HIS A 182
VAL A 235
TYR A 239
ALA A 540
 None
DMS  A 717 ( 3.9A)
W4A  A 716 (-3.8A)
W4A  A 716 ( 3.6A)
W4A  A 716 ( 4.9A)
W4A  A 716 (-4.8A)
DMS  A 717 ( 4.5A)
 0.80A 5xv7A-5myvA:
49.0		 5xv7A-5myvA:
86.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		6 / 12 LEU A  98
GLY A  99
VAL A 106
ALA A 119
PHE A 177
VAL A 240
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.0A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
DMS  A 717 ( 3.9A)
None
 1.22A 5xv7A-5myvA:
49.0		 5xv7A-5myvA:
86.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
GLY A 181
LEU A 232
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
W4A  A 716 (-3.8A)
None
 1.05A 5y7zA-5myvA:
23.9		 5y7zA-5myvA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 LEU A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 136
GLY A 181
LEU A 232
 W4A  A 716 (-4.1A)
W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
W4A  A 716 (-3.8A)
None
 1.05A 5y7zA-5myvA:
23.9		 5y7zA-5myvA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		4 / 4 ILE A 568
LEU A 641
HIS A 609
ALA A 611
 None
 0.87A 6ck2C-5myvA:
undetectable
6ck2D-5myvA:
undetectable		 6ck2C-5myvA:
4.63
6ck2D-5myvA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2
(Homo
sapiens) 		7 / 12 VAL A 106
ALA A 119
LYS A 121
GLU A 136
VAL A 157
LEU A 232
ALA A 540
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
DMS  A 717 ( 4.5A)
 0.99A 6hd4A-5myvA:
19.7		 6hd4A-5myvA:
11.60