SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5mz6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 7 MET 1 468
SER 1 363
PHE 1 476
ALA 1 359
 None
 1.11A 1fxvA-5mz61:
undetectable
1fxvB-5mz61:
undetectable		 1fxvA-5mz61:
10.86
1fxvB-5mz61:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8D_B_CLWB907_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 5 PRO 11135
VAL 11137
TYR 1 902
GLU 1 718
 None
 1.47A 1m8dB-5mz61:
undetectable		 1m8dB-5mz61:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M9J_B_CLWB907_1
(ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 5 PRO 11135
VAL 11137
TYR 1 902
GLU 1 718
 None
 1.41A 1m9jB-5mz61:
undetectable		 1m9jB-5mz61:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX8_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN I, HOLO)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		6 / 12 PHE 1 123
LEU 1 128
ALA 1 309
TYR 1 227
MET 1 180
PHE 1 181
 None
 1.38A 1mx8A-5mz61:
undetectable		 1mx8A-5mz61:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 LEU 1 806
LEU 1 757
TRP 1 916
PHE 1 914
 None
 1.30A 1ru9H-5mz61:
undetectable
1ru9L-5mz61:
undetectable		 1ru9H-5mz61:
10.85
1ru9L-5mz61:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 LEU 1 806
LEU 1 757
TRP 1 916
PHE 1 914
 None
 1.31A 1rukH-5mz61:
undetectable
1rukL-5mz61:
undetectable		 1rukH-5mz61:
10.85
1rukL-5mz61:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SS4_A_ACTA411_0
(GLYOXALASE FAMILY
PROTEIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 5 TRP 1 676
THR 1 680
GLN 1 723
ILE 1 732
 None
 1.20A 1ss4A-5mz61:
undetectable		 1ss4A-5mz61:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 7 THR 11056
THR 11045
SER 1 912
VAL 1 906
 None
 1.13A 1tv8B-5mz61:
undetectable		 1tv8B-5mz61:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 4 LEU 1 806
PRO 1 587
ILE 1 732
LEU 1 748
 None
 1.17A 1ya4C-5mz61:
undetectable		 1ya4C-5mz61:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		5 / 12 LEU 11108
MET 11038
SER 11042
LEU 11073
MET 11112
 None
 1.37A 2aa5B-5mz61:
undetectable		 2aa5B-5mz61:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_B_SAMB501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 7 THR 11056
THR 11045
SER 1 912
VAL 1 906
 None
 1.23A 2fb2B-5mz61:
undetectable		 2fb2B-5mz61:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 MET 1 814
GLY 1 817
LEU 1 812
SER 1 811
 None
 0.94A 3aiaA-5mz61:
undetectable		 3aiaA-5mz61:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 PRO 1 115
LEU 1 118
ARG 1 130
 None
 0.86A 3aqiB-5mz61:
undetectable		 3aqiB-5mz61:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_A_SALA102_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 7 VAL 1 351
ILE 1  41
TYR 1  70
ILE 1  66
 None
 0.89A 3hgxA-5mz61:
undetectable		 3hgxA-5mz61:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 PHE 1 249
TYR 1 646
LEU 1 692
 None
 0.77A 3keeB-5mz61:
undetectable		 3keeB-5mz61:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 VAL 11070
ILE 11012
MET 11112
ARG 11006
 None
 1.11A 3ms9A-5mz61:
undetectable		 3ms9A-5mz61:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 VAL 11070
ILE 11012
MET 11112
ARG 11006
 None
 1.12A 3mssA-5mz61:
undetectable		 3mssA-5mz61:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 PHE 1 249
CYH 1 695
HIS 1 648
 None
 1.15A 3u9fF-5mz61:
undetectable		 3u9fF-5mz61:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 PHE 1 249
CYH 1 695
HIS 1 648
 None
 1.07A 3u9fG-5mz61:
undetectable		 3u9fG-5mz61:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 PHE 1 249
CYH 1 695
HIS 1 648
 None
 1.18A 3u9fL-5mz61:
undetectable		 3u9fL-5mz61:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 PHE 1 249
CYH 1 695
HIS 1 648
 None
 1.07A 3u9fS-5mz61:
undetectable		 3u9fS-5mz61:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		5 / 12 LEU 1 819
ILE 1 828
GLY 1 841
ILE 1 744
ALA 1 843
 None
 1.34A 3uj7A-5mz61:
undetectable		 3uj7A-5mz61:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		5 / 9 THR 1 354
ALA 1 342
TYR 1  70
THR 1  67
LEU 1 384
 None
 1.34A 4ltwA-5mz61:
undetectable		 4ltwA-5mz61:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		5 / 9 THR 1 354
LEU 1 339
ALA 1 342
TYR 1  70
THR 1  67
 None
 1.44A 4ltwA-5mz61:
undetectable		 4ltwA-5mz61:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 8 ILE 1  41
PHE 1  45
THR 1 355
THR 1 354
 None
 0.90A 4n16A-5mz61:
undetectable		 4n16A-5mz61:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 LEU 1  44
GLN 1  38
LEU 1  37
GLU 1  36
 None
 1.28A 4nc3A-5mz61:
undetectable		 4nc3A-5mz61:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_B_ACTB202_0
(RETINOL-BINDING
PROTEIN 2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 7 TYR 1 646
LEU 1 565
GLN 1 557
ARG 1 554
 None
 1.36A 4qzuB-5mz61:
undetectable		 4qzuB-5mz61:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 GLU 1 518
ARG 1 559
GLN 1 353
 None
 0.91A 4rtbA-5mz61:
undetectable		 4rtbA-5mz61:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 ASP 1 562
ALA 1 566
THR 1 324
TYR 1 651
 None
 1.48A 4w5rA-5mz61:
3.5		 4w5rA-5mz61:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 VAL 1 132
ALA 1 151
PHE 1 123
 None
 0.83A 4z4iA-5mz61:
3.8		 4z4iA-5mz61:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 VAL 1 132
ALA 1 151
PHE 1 123
 None
 0.85A 5js1A-5mz61:
undetectable		 5js1A-5mz61:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 PHE 11011
LEU 11036
SER 11042
GLY 11071
 None
 1.14A 5o4yF-5mz61:
undetectable		 5o4yF-5mz61:
1.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 6 GLU 1 258
ALA 1 259
LEU 1 261
SER 1 229
 None
 1.05A 5phhA-5mz61:
undetectable		 5phhA-5mz61:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 5 PHE 1 121
PHE 1  90
LEU 1 118
LEU 1 128
 None
 1.23A 5veuH-5mz61:
undetectable		 5veuH-5mz61:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		5 / 12 LEU 1 128
GLY 1 305
ALA 1 131
THR 1 307
PHE 1 219
 None
 1.34A 5x6yA-5mz61:
undetectable		 5x6yA-5mz61:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		3 / 3 SER 1 176
LYS 1 175
SER 1 177
 None
 0.83A 6az3P-5mz61:
undetectable		 6az3P-5mz61:
5.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		4 / 5 TYR 1 904
GLN 1 931
THR 1 937
LEU 1 941
 None
 1.42A 6d8pA-5mz61:
3.3		 6d8pA-5mz61:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 5mz6 SEPARASE
(Caenorhabditis
elegans) 		5 / 12 LEU 1 953
PRO 1 952
LYS 1 949
ILE 1 955
VAL 1 957
 None
 1.22A 6debB-5mz61:
undetectable		 6debB-5mz61:
5.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 5mz6 SEPARASE
INTERACTOR OF FIZZY
PROTEIN
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		3 / 3 SER 1 176
SER 1 177
ALA B 155
 None
 0.70A 6dwnC-5mz61:
undetectable		 6dwnC-5mz61:
5.60